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| {| style="margin: 5px 10px; width: 600px;" | | {| style="border: 3px solid #696969;" |
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| | style="font-size: 85%; background: #545454; color: #F8F8FF; padding: 5px 10px; font-weight: bold;" | Sepsis = infection (documented or suspected) and some of the following: | | <center><b><font color="#F8F8FF">{{{blackBoxWarningTitle}}}</font></b></center><br> |
| | | <center><font color="#F8F8FF" size="1">''See full prescribing information for complete boxed warning.''</font></center> |
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| | <b><font color="#F8F8FF"><br>{{{blackBoxWarningBody}}}</font></b> |
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| | style="font-size: 85%; background: #DCDCDC; padding: 5px 10px;" | General variables
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| * Fever (>38.3°C)
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| * Hypothermia (core temperature <36°C)
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| * Heart rate >90/min–1 or more than two SD above the normal value for age
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| * Tachypnea
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| * Altered mental status
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| * Significant edema or positive fluid balance (>20 mL/kg over 24 hr)
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| * Hyperglycemia (plasma glucose >140mg/dL or 7.7 mmol/L) in the absence of diabetes
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| | style="font-size: 85%; background: #F5F5F5; padding: 5px 10px;" | Inflammatory variables
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| * Leukocytosis (WBC count >12,000 μL–1)
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| * Leukopenia (WBC count <4000 μL–1)
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| * Normal WBC count with greater than 10% immature forms
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| * Plasma C-reactive protein more than two SD above the normal value
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| * Plasma procalcitonin more than two SD above the normal value
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| | style="font-size: 85%; background: #DCDCDC; padding: 5px 10px;" | Hemodynamic variables
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| * Arterial hypotension (SBP <90mm Hg, MAP <70mm Hg, or an SBP decrease >40mm Hg in adults or less than two SD below normal for age)
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| | style="font-size: 85%; background: #F5F5F5; padding: 5px 10px;" | Organ dysfunction variables
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| * Arterial hypoxemia (Pao2/Fio2 <300)
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| * Acute oliguria (urine output <0.5 mL/kg/hr for at least 2 hrs despite adequate fluid resuscitation)
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| * Creatinine increase >0.5mg/dL or 44.2 μmol/L
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| * Coagulation abnormalities (INR >1.5 or aPTT >60 s)
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| * Ileus (absent bowel sounds)
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| * Thrombocytopenia (platelet count <100,000 μL–1)
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| * Hyperbilirubinemia (plasma total bilirubin >4mg/dL or 70 μmol/L)
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| | style="font-size: 85%; background: #DCDCDC; padding: 5px 10px;" | Tissue perfusion variables
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| * Hyperlactatemia (>1 mmol/L)
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| * Decreased capillary refill or mottling
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| |} | | |} |