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| __NOTOC__
| | #Redirect [[Chronic renal failure pathophysiology#Uremia]] |
| '''For patient information page, click [[{{PAGENAME}} (patient information)|here]]'''
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| {{Infobox_Disease |
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| Name = {{PAGENAME}} |
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| Image = Urea.png |
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| Caption = [[Urea]] |
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| DiseasesDB = 26060 |
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| ICD10 = {{ICD10|R|39|2|r|30}} |
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| ICD9 = {{ICD9|585}}-{{ICD9|586}}, {{ICD9|788.9}} |
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| ICDO = |
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| OMIM = |
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| MedlinePlus = |
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| MeshID = D014511 |
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| }}
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| {{Uremia}}
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| {{CMG}}
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| '''Uremia''' is a term used to loosely describe the illness accompanying [[renal failure | kidney failure]]. In kidney failure, [[urea]] and other waste products, which are normally excreted into the urine, are retained in the blood. Early symptoms include anorexia and lethargy, and late symptoms can include decreased mental acuity and coma. It is usually diagnosed in [[kidney dialysis]] patients when the [[glomerular filtration rate]], a measure of kidney function, is below 50% of normal.<ref>{{cite journal | author = Meyer TW and Hostetter, TH| title = Uremia| journal = N Engl J Med | volume = 357 | issue = 13 | pages = 1316 | year = 2007 | id = PMID 17898101}} [http://content.nejm.org/cgi/content/full/357/13/1316 Full text].</ref>
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| [[Azotemia]] is another word that refers to high levels of urea, but is used primarily when the abnormality can be measured chemically but is not yet so severe as to produce symptoms. Uremia can also result in [[Pericarditis#Fibrinous pericarditis|fibrinous pericarditis]]. There are many dysfunctions caused by uremia affecting many systems of the body, such as blood (lower levels of erythropoietin), Sex (lower levels of testosterone/oestrogen) and bones (osteoperosis
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| and metastatic calcifications).
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| ==Causes==
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| Besides [[renal failure]], the level of urea in the blood can also be increased by:
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| *increased production of urea in the liver, due to:
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| **high protein diet
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| **increased protein breakdown (surgery, infection, trauma, cancer)
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| **gastrointestinal bleeding
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| **drugs (e.g. [[tetracyclines]] and [[corticosteroids]])
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| *decreased elimination of urea, due to:
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| **decreased blood flow through kidney (e.g. [[hypotension]], cardiac failure)
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| **urinary outflow obstruction
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| *dehydration
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| == See also ==
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| *[[Azotemia]]
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| *[[Nephrology]]
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| *[[Renal failure]]
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| <br>
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| [[ar:بولينا]]
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| [[da:Uræmi]]
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| [[de:Urämie]]
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| [[es:Uremia]]
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| [[fr:Urémie]]
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| [[id:Uremia]]
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| [[it:Uremia]]
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| [[no:Uremi]]
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| [[pl:Mocznica]]
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| [[ru:Уремия]]
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| [[sv:Uremi]]
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| [[zh:尿毒症]]
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| {{WikiDoc Help Menu}}
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| {{WikiDoc Sources}}
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| [[Category:Nitrogen metabolism]]
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| [[Category:Kidney diseases]]
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| [[Category:Organ failure]]
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| [[Category:Causes of death]]
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| [[Category:Nephrology]]
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| [[Category:Signs and symptoms]]
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