Ampicillin sulbactam: Difference between revisions

Jump to navigation Jump to search
mNo edit summary
m (Redirected page to Ampicillin-Sulbactam)
 
(4 intermediate revisions by the same user not shown)
Line 1: Line 1:
__NOTOC__
#REDIRECT [[Ampicillin-Sulbactam]]
{{Ampicillin sulbactam}}
{{CMG}}
 
==Overview==
Ampicillin/sulbactam, the combination of [[ampicillin]] with [[sulbactam]] (an irreversible [[beta-lactamase inhibitor|beta-lactamase inhibitor]]), has an antimicrobial spectrum  similar to that of [[amoxicillin]]-[[clavulanic acid|clavulanate]] that includes [[methicillin]]-sensitive strains of [[Staphylococcus aureus]], [[Enterobacteriaceae]] (but not resistant strains of [[Escherichia coli]] or [[Pseudomonas aeruginosa]]), and [[anaerobe]]s. The agent has been used effectively to treat polymicrobial intra-abdominal and pelvic infections. It may also be used for soft tissue infections secondary to human or animal bites.<ref name="Lode-2008">{{Cite journal | last1 = Lode | first1 = HM. | title = Rational antibiotic therapy and the position of ampicillin/sulbactam. | journal = Int J Antimicrob Agents | volume = 32 | issue = 1 | pages = 10-28 | month = Jul | year = 2008 | doi = 10.1016/j.ijantimicag.2008.02.004 | PMID = 18539004 }}</ref>
 
==Category==
Penicillin/β-lactamase inhibitor
 
==US Brand Names==
Unasyn<sup>®</sup>
 
==FDA Package Insert==
'''[[Ampicillin sulbactam description|Description]]'''
'''| [[Ampicillin sulbactam clinical pharmacology|Clinical Pharmacology]]'''
'''| [[Ampicillin sulbactam microbiology|Microbiology]]'''
'''| [[Ampicillin sulbactam indications and usage|Indications and Usage]]'''
'''| [[Ampicillin sulbactam contraindications|Contraindications]]'''
'''| [[Ampicillin sulbactam warnings|Warnings]]'''
'''| [[Ampicillin sulbactam precautions|Precautions]]'''
'''| [[Ampicillin sulbactam adverse reactions|Adverse Reactions]]'''
'''| [[Ampicillin sulbactam overdosage|Overdosage]]'''
'''| [[Ampicillin sulbactam clinical studies|Clinical Studies]]'''
'''| [[Ampicillin sulbactam dosage and administration|Dosage and Administration]]'''
'''| [[Ampicillin sulbactam compatibility reconstitution and stability|Compatibility, Reconstitution, and Stability]]'''
'''| [[Ampicillin sulbactam directions for use|Directions For Use]]'''
'''| [[Ampicillin sulbactam how supplied|How Supplied]]'''
'''| [[Ampicillin sulbactam other size packages available|Other Size Packages Available]]'''
'''| [[Ampicillin sulbactam labels and packages|Labels and Packages]]'''
 
==Mechanisms of Action==
Ampicillin inhibits bacterial cell wall synthesis by binding to [[penicillin]]-binding proteins which in turn inhibits the transpeptidation (cross-linking) of [[peptidoglycan]]. Thus, cell wall assembly is interrupted and bacteria are lyzed by [[autolysins]] and murein [[hydrolase]]s. Sulbactam irreversibly inhibit [[plasmid]]-mediated [[beta-lactamases]]which are frequently accountable for [[drug resistance]]. In addition, sulbactam has modest activity ''in vitro'' against strains of [[Acinetobacter baumannii]].<ref name="Higgins-2004">{{Cite journal | last1 = Higgins | first1 = PG. | last2 = Wisplinghoff | first2 = H. | last3 = Stefanik | first3 = D. | last4 = Seifert | first4 = H. | title = In vitro activities of the beta-lactamase inhibitors clavulanic acid, sulbactam, and tazobactam alone or in combination with beta-lactams against epidemiologically characterized multidrug-resistant Acinetobacter baumannii strains. | journal = Antimicrob Agents Chemother | volume = 48 | issue = 5 | pages = 1586-92 | month = May | year = 2004 | doi = | PMID = 15105109}}</ref> The presence of sulbactam in the formulation extends the spectrum of ampicillin to include beta-lactamase producing strains.
 
==References==
{{Reflist|2}}
 
[[Category:Antibiotics]]
[[Category:Wikinfect]]

Latest revision as of 19:05, 4 April 2015