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{{drugbox
<div style="float: right;">
| IUPAC_name        = (9α,13α,14α)-3,17-dimethylmorphinan
[[File:Dimemorfan.png|thumb|none|400px|This image is provided by the National Library of Medicine.]]</div>
| image            = Dimemorfan.png
__NOTOC__
| CAS_number        = 36309-01-0
{{SI}}
| ATC_prefix        = R05
{{CMG}}
| ATC_suffix        = DA11
==Overview==
| PubChem          = 3037918
'''Dimemorfan''' is an [[antitussive]] or [[cough suppressant]] which acts as a [[sigma receptor]] [[agonist]].It is an [[Functional analog|analogue]] of [[dextromethorphan]] and [[dextrorphan]], but lacks significant [[NMDA receptor antagonist]]ic action and [[dissociative]] effects, thereby having reduced [[abuse potential]] and [[adverse effect]]s in comparison.
| DrugBank          =
| C=18|H=25|N=1
| molecular_weight  = 255.398 g/mol
| bioavailability  =
| protein_bound    =
| metabolism        =
| elimination_half-life =
| excretion        =
| pregnancy_AU      =  <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US      =  <!-- A / B            / C / D / X -->
| pregnancy_category= 
| legal_AU          =  <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
| legal_CA          =  <!--            / Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK          = <!-- GSL        / P      / POM / CD / Class A, B, C -->
| legal_US          = <!-- OTC                  / Rx-only  / Schedule I, II, III, IV, V -->
| legal_status      =  
| routes_of_administration =  
}}
 
'''Dimemorfan''' is a [[cough suppressant]] which acts as a [[sigma receptor|sigma]] [[agonist]].<ref>Hui-Hung Wang, Jyh-Wei Chien, Yueh-Ching Chou, Jyh-Fei Liao and Chieh-Fu Chen. Anti-amnesic effect of dimemorfan in mice. British Journal of Pharmacology (2003) 138, 941–949.</ref><ref>Eun-Joo Shin, Seung-Yeol Nah, Won-Ki Kim, Kwang Ho Ko, Wang-Kee Jhoo, Yong-Kwang Lim, Joo Young Cha, Chieh-Fu Chen and Hyoung-Chun Kim. The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via sigma1 receptor activation: comparison with the effects of dextromethorphan. British Journal of Pharmacology (2005) 144, 908–918.</ref>


== See also ==
* [[Cough syrup]]
* [[Dextromethorphan]]
* [[Dextrorphan]]
* [[Morphinan]]


== References ==
== References ==
{{reflist|2}}
{{Reflist|2}}
 
{{pharmacology-stub}}
 
{{Cough and cold preparations}}


[[Category:Antitussives]]
[[Category:Antitussives]]
[[Category:Morphinans]]
[[Category:Morphinans]]
[[Category:Drug]]

Latest revision as of 14:24, 7 April 2015

This image is provided by the National Library of Medicine.

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Dimemorfan is an antitussive or cough suppressant which acts as a sigma receptor agonist.It is an analogue of dextromethorphan and dextrorphan, but lacks significant NMDA receptor antagonistic action and dissociative effects, thereby having reduced abuse potential and adverse effects in comparison.

See also

References

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