Oxetacaine: Difference between revisions

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Oxetacaine
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral, topical
ATC code	C05AD06 (WHO) ;
Pharmacokinetic data
Elimination half-life	1 hour
Identifiers
	IUPAC name 2,2'-(2-hydroxyethylimino)bis [N-(1,1-dimethyl-2- phenylethyl)-N-methylacetamide];
CAS Number	126-27-2 ;
PubChem CID	4621;
ChemSpider	4460 ;
UNII	IP8QT76V17;
KEGG	D01152 ;
ChEMBL	ChEMBL127592 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C28H41N3O3
Molar mass	467.643 g/mol
3D model (JSmol)	Interactive image;
	SMILES O=C(N(C(C)(C)Cc1ccccc1)C)CN(CCO)CC(=O)N(C(Cc2ccccc2)(C)C)C;
	InChI InChI=1S/C28H41N3O3/c1-27(2,19-23-13-9-7-10-14-23)29(5)25(33)21-31(17-18-32)22-26(34)30(6)28(3,4)20-24-15-11-8-12-16-24/h7-16,32H,17-22H2,1-6H3 ; Key:FTLDJPRFCGDUFH-UHFFFAOYSA-N ;
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VisualWikitext

Latest revision as of 16:02, 8 April 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Oxetacaine (INN, also known as oxethazaine) is a potent local anesthetic. It is administered orally (usually in combination with an antacid) for the relief of pain associated with peptic ulcer disease or esophagitis. It is also used topically in the management of hemorrhoid pain. Oral oxetacaine preparations are available in several countries, including India, South Africa, Japan and Brazil, but not the United States.

Unlike most local anesthetics, oxetacaine is active even in strongly acidic conditions.^[1]

References

↑ Seifter J, Glassman JM, Hudyma GM (1962). "Oxethazaine and related congeners: a series of highly potent local anesthetics". Proc Soc Exp Biol Med. 109: 664–8. doi:10.3181/00379727-109-27300. PMID 13910333.

Template:Vasoprotectives

[1] Seifter J, Glassman JM, Hudyma GM (1962). "Oxethazaine and related congeners: a series of highly potent local anesthetics". Proc Soc Exp Biol Med. 109: 664–8. doi:10.3181/00379727-109-27300. PMID 13910333.

[1]

@@ Line 3: / Line 3: @@
 | verifiedrevid = 462267014
 | IUPAC_name = 2,2'-(2-hydroxyethylimino)bis [''N''-(1,1-dimethyl-2- phenylethyl)-''N''-methylacetamide]
-| image = Oxetacaine.svg
+| image = Oxetacaine.png
 | width = 280
@@ Line 55: / Line 55: @@
 }}
 __NOTOC__
 {{SI}}
 {{CMG}}
 ==Overview==
 '''Oxetacaine''' ([[International Nonproprietary Name|INN]], also known as '''oxethazaine''') is a potent [[local anesthetic]]. It is administered orally (usually in combination with an [[antacid]]) for the relief of pain associated with [[peptic ulcer disease]] or [[esophagitis]]. It is also used topically in the management of [[hemorrhoid]] pain. Oral oxetacaine preparations are available in several countries, including [[India]], [[South Africa]], [[Japan]] and [[Brazil]], but not the United States.
@@ Line 72: / Line 69: @@
 [[Category:Local anesthetics]]
-[[Category:Acetamides]]
 [[Category:Alcohols]]
 [[Category:Drug]]

v t e Anesthetics: Local anesthetics (N01B)
Esters of aminobenzoic acid	Amylocaine, Benzocaine, Butacaine, Chloroprocaine, Dimethocaine, Meprylcaine, Orthocaine, Propoxycaine, Procaine, Proparacaine, Risocaine, Tetracaine
Amides	Articaine, Bupivacaine, Carticaine, Cinchocaine, Etidocaine, Levobupivacaine, Lidocaine, Mepivacaine, Prilocaine, Ropivacaine, Trimecaine
Esters of benzoic acid	Cocaine, Piperocaine
Other	Hexylcaine, Iontocaine, Lidocaine/prilocaine

Clinical data

AHFS/Drugs.com	International Drug Names
Routes of administration	Oral, topical
ATC code	C05AD06 (WHO)
Pharmacokinetic data
Elimination half-life	1 hour
Identifiers
IUPAC name 2,2'-(2-hydroxyethylimino)bis [N-(1,1-dimethyl-2- phenylethyl)-N-methylacetamide]
CAS Number	126-27-2^N
PubChem CID	4621
ChemSpider	4460^Y
UNII	IP8QT76V17
KEGG	D01152^Y
ChEMBL	ChEMBL127592^Y
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₂₈H₄₁N₃O₃
Molar mass	467.643 g/mol
3D model (JSmol)	Interactive image
SMILES O=C(N(C(C)(C)Cc1ccccc1)C)CN(CCO)CC(=O)N(C(Cc2ccccc2)(C)C)C
InChI InChI=1S/C28H41N3O3/c1-27(2,19-23-13-9-7-10-14-23)29(5)25(33)21-31(17-18-32)22-26(34)30(6)28(3,4)20-24-15-11-8-12-16-24/h7-16,32H,17-22H2,1-6H3^Y Key:FTLDJPRFCGDUFH-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)

Oxetacaine: Difference between revisions

Latest revision as of 16:02, 8 April 2015

Overview

References

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