Mebhydrolin: Difference between revisions

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Mebhydrolin
Clinical data
Synonyms	9-Benzyl-2-methyl-2,3,4,9-tetrahydro-1H-gamma-carboline, Incidal, Omeril, diazolin, Fabahistin, mebhydrolin napadisylate, mebhydroline 1,5-naphthalenedisulfonate
AHFS/Drugs.com	International Drug Names
Pregnancy; category	Not established;
Routes of; administration	oral
ATC code	R06AX15 (WHO) ;
Identifiers
	IUPAC name 5-benzyl-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole;
CAS Number	524-81-2 6153-33-9;
PubChem CID	22530;
ChemSpider	21129 ;
UNII	9SUK9B7XVY;
KEGG	D08161 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C19H20N2
Molar mass	276.376 g/mol
3D model (JSmol)	Interactive image;
	SMILES CN3Cc4c1ccccc1n(Cc2ccccc2)c4CC3;
	InChI InChI=1S/C19H20N2/c1-20-12-11-19-17(14-20)16-9-5-6-10-18(16)21(19)13-15-7-3-2-4-8-15/h2-10H,11-14H2,1H3 ; Key:FQQIIPAOSKSOJM-UHFFFAOYSA-N ;
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VisualWikitext

Latest revision as of 18:12, 8 April 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Mebhydrolin (INN) or mebhydroline is an antihistamine. It is not available in the United States, but it is in various other countries. It is also called Bexidal (BD) and Diazolin (RU). It is used for symptomatic relief of allergic symptoms caused by histamine release, including nasal allergies and allergic dermatosis.

Mebhydrolin has been shown to enhance the performance-deficit effects of alcohol.^[5]

References

↑ ^1.0 ^1.1 "FABAHISTIN 50 mg (Tablets)". South African Electronic Package Inserts. September 1970. Retrieved 2007-03-02.^{[dead link]}
↑ "Mebhydroline". National Library of Medicine - Medical Subject Headings. US National Institutes of Health, National Library of Medicine. Retrieved 2007-03-02.
↑ "Diazoline". National Library of Medicine - Medical Subject Headings. US National Institutes of Health, National Library of Medicine. Retrieved 2007-03-02.
↑ "Mebhydrolin chemical information". PubChem. Retrieved 2007-03-02.
↑ Franks HM, Lawrie M, Schabinsky VV, Starmer GA, Teo RK (October 1981). "Interaction between ethanol and antihistamines: 3. mebhydrolin". Med. J. Aust. 2 (9): 477–9. PMID 6119605.

[Intekom-1] 1.0 ^1.1 "FABAHISTIN 50 mg (Tablets)". South African Electronic Package Inserts. September 1970. Retrieved 2007-03-02.^{[dead link]}

[MeSH_mebhydroline-2] "Mebhydroline". National Library of Medicine - Medical Subject Headings. US National Institutes of Health, National Library of Medicine. Retrieved 2007-03-02.

[MeSH_diazoline-3] "Diazoline". National Library of Medicine - Medical Subject Headings. US National Institutes of Health, National Library of Medicine. Retrieved 2007-03-02.

[ChemIndustry-4] "Mebhydrolin chemical information". PubChem. Retrieved 2007-03-02.

[5] Franks HM, Lawrie M, Schabinsky VV, Starmer GA, Teo RK (October 1981). "Interaction between ethanol and antihistamines: 3. mebhydrolin". Med. J. Aust. 2 (9): 477–9. PMID 6119605.

[2]

[1]

[3]

[4]

[5]

@@ Line 1: / Line 1: @@
-{{drugbox |
+{{Drugbox
-| IUPAC_name        = 9-Benzyl-2-methyl-2,3,4,9-tetrahydro-1H-β-carboline
+| Verifiedfields = changed
-| image             =
+| Watchedfields = changed
-| ATC_prefix        = R06
+| verifiedrevid = 462100967
-| ATC_suffix        = AX15
+| IUPAC_name = 5-benzyl-2-methyl-2,3,4,5-tetrahydro-1''H''-pyrido[4,3-''b'']indole
-| CAS_number        = 524-81-2
+| image = Mebhydroline.png
-| CAS_supplemental  = 6153-33-9<ref name="MeSH diazoline">{{cite web |url=http://www.nlm.nih.gov/cgi/mesh/2006/MB_cgi?mode=&term=diazoline |title=Diazoline |publisher=US National Institutes of Health, National Library of Medicine |accessdate=2007-03-02 |format=HTML |work=National Library of Medicine - Medical Subject Headings }}</ref>
-| PubChem = 10458737
+<!--Clinical data-->
-| C = 19 |H = 20 |N = 2<ref name="ChemIndustry">{{cite web |url=http://www.chemindustry.com/chemicals/969111.html |title=Mebhydrolin chemical information |accessdate=2007-03-02 |format=HTML |work=PubChem}}</ref>
+| tradename =
-| molecular_weight  = 276.376 g/mol
+| Drugs.com = {{drugs.com|international|mebhydrolin}}
-| smiles            = CN1CCC2=C(C1)C3=CC=CC=C3N2CC4=CC=CC=C4
+| pregnancy_category = Not established<ref name="Intekom">{{cite web | url = http://home.intekom.com/pharm/bayer/fabahist.html | title = FABAHISTIN 50 mg (Tablets) | date = September 1970 | accessdate = 2007-03-02 | work = South African Electronic Package Inserts}} {{Dead link|date=October 2010|bot=H3llBot}}</ref>
-| synonyms          = Incidal, Omeril, diazolin, Fabahistin, mebhydrolin napadisylate, mebhydroline 1,5-naphthalenedisulfonate<ref name="MeSH mebhydroline">{{cite web |url=http://www.nlm.nih.gov/cgi/mesh/2006/MB_cgi?mode=&term=mebhydroline |title=Mebhydroline |publisher=US National Institutes of Health, National Library of Medicine |accessdate=2007-03-02 |format=HTML |work=National Library of Medicine - Medical Subject Headings }}</ref>
-| pregnancy_category=  Not established<ref name="Intekom">{{cite web |url=http://www.intekom.com/pharm/bayer/fabahist.html |title=FABAHISTIN 50 mg (Tablets) |date=1970-09 |accessdate=2007-03-02 |format=HTML |work=South African Electronic Package Inserts }}</ref>
 | routes_of_administration = oral<ref name="Intekom"/>
+<!--Identifiers-->
+| CAS_number_Ref = {{cascite|changed|??}}
+| CAS_number = 524-81-2
+| CAS_supplemental = 6153-33-9<ref name="MeSH diazoline">{{cite web | url = http://www.nlm.nih.gov/cgi/mesh/2006/MB_cgi?mode=&term=diazoline | title = Diazoline | publisher = US National Institutes of Health, National Library of Medicine | accessdate = 2007-03-02 | work = National Library of Medicine - Medical Subject Headings}}</ref>
+| ATC_prefix = R06
+| ATC_suffix = AX15
+| PubChem = 22530
+| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
+| ChemSpiderID = 21129
+| UNII_Ref = {{fdacite|correct|FDA}}
+| UNII = 9SUK9B7XVY
+| KEGG_Ref = {{keggcite|correct|kegg}}
+| KEGG = D08161
+<!--Chemical data-->
+| C=19 | H=20 | N=2<ref name="ChemIndustry">{{cite web | url = http://www.chemindustry.com/chemicals/969111.html | title = Mebhydrolin chemical information | accessdate = 2007-03-02 | work = PubChem}}</ref>
+| molecular_weight = 276.376 g/mol
+| smiles = CN3Cc4c1ccccc1n(Cc2ccccc2)c4CC3
+| InChI = 1/C19H20N2/c1-20-12-11-19-17(14-20)16-9-5-6-10-18(16)21(19)13-15-7-3-2-4-8-15/h2-10H,11-14H2,1H3
+| InChIKey = FQQIIPAOSKSOJM-UHFFFAOYAM
+| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
+| StdInChI = 1S/C19H20N2/c1-20-12-11-19-17(14-20)16-9-5-6-10-18(16)21(19)13-15-7-3-2-4-8-15/h2-10H,11-14H2,1H3
+| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
+| StdInChIKey = FQQIIPAOSKSOJM-UHFFFAOYSA-N
+| synonyms = 9-Benzyl-2-methyl-2,3,4,9-tetrahydro-1H-gamma-carboline, Incidal, Omeril, diazolin, Fabahistin, mebhydrolin napadisylate, mebhydroline 1,5-naphthalenedisulfonate<ref name="MeSH mebhydroline">{{cite web | url = http://www.nlm.nih.gov/cgi/mesh/2006/MB_cgi?mode=&term=mebhydroline | title = Mebhydroline | publisher = US National Institutes of Health, National Library of Medicine | accessdate = 2007-03-02 | work = National Library of Medicine - Medical Subject Headings}}</ref>
 }}
+__NOTOC__
 {{SI}}
+{{CMG}}
-{{EH}}
 ==Overview==
 '''Mebhydrolin''' ([[International Nonproprietary Name|INN]]) or '''mebhydroline''' is an [[antihistamine]]. It is not available in the United States, but it is in various other countries. It is also called Bexidal (BD) and Diazolin (RU).  It is used for symptomatic relief of allergic symptoms caused by histamine release, including nasal allergies and allergic dermatosis.
-Mebhydrolin has been shown to enhance the performance-deficit effects of alcohol.<ref>{{cite web |url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6119605&dopt=Abstract |title=Interaction between ethanol and antihistamines: 3. mebhydrolin. |accessdate=2007-03-02 |last=Franks |first=HM |coauthors= M. Lawrie, VV Schabinsky, GA Starmer, RK Teo |date=1981-10-31 |format=HTML |work=Med J Aust. |language=English }}</ref>
+Mebhydrolin has been shown to enhance the performance-deficit effects of alcohol.<ref>{{cite journal |author=Franks HM, Lawrie M, Schabinsky VV, Starmer GA, Teo RK |title=Interaction between ethanol and antihistamines: 3. mebhydrolin |journal=Med. J. Aust. |volume=2 |issue=9 |pages=477–9 |date=October 1981 |pmid=6119605 }}</ref>
 ==References==
-<references />
+{{Reflist|2}}
 {{Antihistamines}}
-[[Category:Antihistamines]]
+[[Category:H1 receptor antagonists]]
-[[Category:Indoles]]
+[[Category:Drug]]
-{{SIB}}
-{{WH}}
-{{WikiDoc Sources}}

v t e Antihistamines (R06)
Aminoalkyl ethers	Bromazine/Bromodiphenhydramine • Carbinoxamine • Clemastine • Chlorphenoxamine • Diphenylpyraline • Diphenhydramine • Doxylamine • Orphenadrine • Phenyltoloxamine
Substituted alkylamines	Brompheniramine • Chlorphenamine • Dexbrompheniramine • Dexchlorpheniramine • Dimetindene • Pheniramine • Talastine
Substituted ethylenediamines	Chloropyramine • Histapyrrodine • Mepyramine • Methapyrilene • Tripelennamine (Pyribenzamine)
Phenothiazine derivatives	Alimemazine • Hydroxyethylpromethazine • Isothipendyl • Mequitazine • Methdilazine • Oxomemazine • Promethazine
Piperazine derivatives	Buclizine • Cetirizine • Chlorcyclizine • Cinnarizine • Cyclizine • Hydroxyzine • Levocetirizine • Meclizine • Niaprazine • Oxatomide
Others for systemic use	Antazoline • Azatadine • Bamipine • Cyproheptadine • Deptropine • Dimebon • Ebastine • Epinastine • Ketotifen • Mebhydrolin • Mizolastine • Phenindamine • Pimethixene • Pyrrobutamine • Rupatadine • Triprolidine • selective (Acrivastine • Astemizole • Azelastine • Desloratadine • Fexofenadine • Loratadine • Terfenadine)
For topical use	Bamipine • Chloropyramine • Chlorphenoxamine • Clemastine • Dimetindene • Diphenhydramine • Isothipendyl • Mepyramine • Promethazine • Thenalidine
Antiallergic agents excluding corticosteroids	Antazoline • Azelastine
Other antiallergics	Emedastine • Epinastine • Ketotifen • Montelukast • Olopatadine

Mebhydrolin: Difference between revisions

Latest revision as of 18:12, 8 April 2015

Overview

References

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