Thenalidine: Difference between revisions

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Thenalidine
Clinical data
ATC code	D04AA03 (WHO) R06AX03 (WHO) ; R06AX53 (WHO) (combinations);
Identifiers
	IUPAC name 1-Methyl-N-phenyl-N-(2-thienylmethyl)piperidin-4-amine;
CAS Number	86-12-4 ;
PubChem CID	27901;
DrugBank	DB04826 ;
ChemSpider	25957 ;
UNII	6U94N2D00F;
KEGG	D07194 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C17H22N2S
Molar mass	286.436 g/mol
3D model (JSmol)	Interactive image;
	SMILES s1c(ccc1)CN(c2ccccc2)C3CCN(C)CC3;
	InChI InChI=1S/C17H22N2S/c1-18-11-9-16(10-12-18)19(14-17-8-5-13-20-17)15-6-3-2-4-7-15/h2-8,13,16H,9-12,14H2,1H3 ; Key:KLOHYVOVXOUKQI-UHFFFAOYSA-N ;
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VisualWikitext

Latest revision as of 18:59, 8 April 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Thenalidine is an antihistamine with anticholinergic properties used as an antipruritic drug.^[1] It was withdrawn from the US, Canadian, and UK markets in 1963 due to a risk of neutropenia.^[2]

References

↑ PMID 13629433 (PMID 13629433)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand
↑ "Thenalidine". DrugBank.

Template:Antipruritics

[1] PMID 13629433 (PMID 13629433)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand

[2] "Thenalidine". DrugBank.

[1]

[2]

@@ Line 4: / Line 4: @@
 | verifiedrevid = 447809040
 | IUPAC_name = 1-Methyl-''N''-phenyl-''N''-(2-thienylmethyl)piperidin-4-amine
-| image = Thenalidine.svg
+| image = Thenalidine.png
 <!--Clinical data-->
@@ Line 46: / Line 46: @@
 | molecular_weight = 286.436 g/mol
 }}
+                     __NOTOC__
+{{SI}}
+{{CMG}}
+==Overview==
 '''Thenalidine''' is an [[antihistamine]] with [[anticholinergic]] properties used as an [[antipruritic]] drug.<ref>{{cite pmid|13629433}}</ref>  It was withdrawn from the US, Canadian, and UK markets in 1963 due to a risk of [[neutropenia]].<ref>{{cite web | url = http://www.drugbank.ca/drugs/DB04826 | title = Thenalidine | publisher = [[DrugBank]]}}</ref>
+==References==
-== References ==
+{{Reflist|2}}
-{{Reflist}}
 {{Antipruritics}}
 {{Antihistamines}}
-{{Cholinergics}}
-{{Histaminergics}}
 [[Category:H1 receptor antagonists]]
 [[Category:Piperidines]]
 [[Category:Thiophenes]]
-[[Category:Anilines]]
+[[Category:Drug]]
 [[Category:Withdrawn drugs]]
-{{respiratory-system-drug-stub}}
-{{dermatologic-drug-stub}}

v t e Antihistamines (R06)
Aminoalkyl ethers	Bromazine/Bromodiphenhydramine • Carbinoxamine • Clemastine • Chlorphenoxamine • Diphenylpyraline • Diphenhydramine • Doxylamine • Orphenadrine • Phenyltoloxamine
Substituted alkylamines	Brompheniramine • Chlorphenamine • Dexbrompheniramine • Dexchlorpheniramine • Dimetindene • Pheniramine • Talastine
Substituted ethylenediamines	Chloropyramine • Histapyrrodine • Mepyramine • Methapyrilene • Tripelennamine (Pyribenzamine)
Phenothiazine derivatives	Alimemazine • Hydroxyethylpromethazine • Isothipendyl • Mequitazine • Methdilazine • Oxomemazine • Promethazine
Piperazine derivatives	Buclizine • Cetirizine • Chlorcyclizine • Cinnarizine • Cyclizine • Hydroxyzine • Levocetirizine • Meclizine • Niaprazine • Oxatomide
Others for systemic use	Antazoline • Azatadine • Bamipine • Cyproheptadine • Deptropine • Dimebon • Ebastine • Epinastine • Ketotifen • Mebhydrolin • Mizolastine • Phenindamine • Pimethixene • Pyrrobutamine • Rupatadine • Triprolidine • selective (Acrivastine • Astemizole • Azelastine • Desloratadine • Fexofenadine • Loratadine • Terfenadine)
For topical use	Bamipine • Chloropyramine • Chlorphenoxamine • Clemastine • Dimetindene • Diphenhydramine • Isothipendyl • Mepyramine • Promethazine • Thenalidine
Antiallergic agents excluding corticosteroids	Antazoline • Azelastine
Other antiallergics	Emedastine • Epinastine • Ketotifen • Montelukast • Olopatadine

Clinical data

ATC code	D04AA03 (WHO) R06AX03 (WHO) R06AX53 (WHO) (combinations)
Identifiers
IUPAC name 1-Methyl-N-phenyl-N-(2-thienylmethyl)piperidin-4-amine
CAS Number	86-12-4^Y
PubChem CID	27901
DrugBank	DB04826^Y
ChemSpider	25957^N
UNII	6U94N2D00F
KEGG	D07194^Y
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₁₇H₂₂N₂S
Molar mass	286.436 g/mol
3D model (JSmol)	Interactive image
SMILES s1c(ccc1)CN(c2ccccc2)C3CCN(C)CC3
InChI InChI=1S/C17H22N2S/c1-18-11-9-16(10-12-18)19(14-17-8-5-13-20-17)15-6-3-2-4-7-15/h2-8,13,16H,9-12,14H2,1H3^N Key:KLOHYVOVXOUKQI-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

Thenalidine: Difference between revisions

Latest revision as of 18:59, 8 April 2015

Overview

References

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