Diiodohydroxyquinoline: Difference between revisions

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Diiodohydroxyquinoline
Names
	IUPAC name 5,7-diiodoquinolin-8-ol
	Other names Diquinol, iodoxin, diiodoquin, amebaquin
Identifiers
CAS Number	83-73-8 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL86754 ;
ChemSpider	3597 ;
ECHA InfoCard	Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value).
KEGG	D00581 ;
MeSH	Iodoquinol
PubChem CID	3728;
UNII	63W7IE88K8 ;
	InChI InChI=1S/C9H5I2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H Key: UXZFQZANDVDGMM-UHFFFAOYSA-N ; InChI=1/C9H5I2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H Key: UXZFQZANDVDGMM-UHFFFAOYAF;
	SMILES C1=CC2=C(C(=C(C=C2I)I)O)N=C1;
Properties
Chemical formula	C9H5I2NO
Molar mass	396.951
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is ?)
	Infobox references

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VisualWikitext

Latest revision as of 13:39, 9 April 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

The quinoline derivative diiodohydroxyquinoline (INN) or iodoquinol (USAN), can be used in the treatment of amoebiasis. It is poorly absorbed from the gastrointestinal tract and is used as a luminal amebicide. It acts by chelation of ferrous ions essential for metabolism. It was discovered by Adco Co. and introduced as diiodohydroxyquinoline. Susceptibility of Dientamoeba fragilis has been measured. Iodoquinol is an amebocide used against Entamoeba histolytica, and it is active against both cysts and trophozoites that are localized in the lumen of the intestine. It is considered the drug of choice for treating asymptomatic or moderate forms of amebiasis. The mechanism of action is unknown. Iodoquinol is used for diseases caused by moderate intestinal amebiasis.

References

@@ Line 51: / Line 51: @@
 __NOTOC__
 {{SI}}
 {{CMG}}
 ==Overview==
-The [[quinoline]] derivative '''diiodohydroxyquinoline''' ([[International Nonproprietary Name|INN]]) or '''iodoquinol''' ([[United States Adopted Name|USAN]]), can be used in the treatment of [[amoebiasis]].<ref name="pmid2493578">{{cite journal |author=Ghaskadbi S, Vaidya VG |title=In vivo antimutagenic effect of ascorbic acid against mutagenicity of the common antiamebic drug diiodohydroxyquinoline |journal=Mutat. Res. |volume=222 |issue=3 |pages=219–22 |date=March 1989 |pmid=2493578 |doi= 10.1016/0165-1218(89)90137-7|url=}}</ref>
+The [[quinoline]] derivative '''diiodohydroxyquinoline''' ([[International Nonproprietary Name|INN]]) or '''iodoquinol''' ([[United States Adopted Name|USAN]]), can be used in the treatment of [[amoebiasis]].
+It is poorly absorbed from the [[gastrointestinal tract]] and is used as a luminal amebicide. It acts by [[chelation]] of [[ferrous ion]]s essential for metabolism.
-It is poorly absorbed from the [[gastrointestinal tract]] and is used as a luminal amebicide. It acts by [[chelation]] of [[ferrous ion]]s essential for metabolism.<ref>{{cite web|url=http://web.gideononline.com/web/therapy/index.php?type=drugs&code=20130&view=General |work=Gideon Online}}</ref>
+It was discovered by Adco Co. and introduced as ''diiodohydroxyquinoline''.
+Susceptibility of ''[[Dientamoeba fragilis]]'' has been measured.
-It was discovered by Adco Co. and introduced as ''diiodohydroxyquinoline''.<ref>Page 1312. http://books.google.co.in/books?id=TIu28TH_iAYC&printsec=frontcover&source=gbs_ge_summary_r&cad=0#v=onepage&q&f=false</ref>
-Susceptibility of ''[[Dientamoeba fragilis]]'' has been measured.<ref name="pmid8067755">{{cite journal |author=Chan FT, Guan MX, Mackenzie AM, Diaz-Mitoma F |title=Susceptibility testing of Dientamoeba fragilis ATCC 30948 with iodoquinol, paromomycin, tetracycline, and metronidazole |journal=Antimicrob. Agents Chemother. |volume=38 |issue=5 |pages=1157–60 |date=May 1994 |pmid=8067755 |pmc=188168 |doi= 10.1128/aac.38.5.1157|url=http://aac.asm.org/cgi/pmidlookup?view=long&pmid=8067755}}</ref>
 Iodoquinol is an amebocide used against ''[[Entamoeba histolytica]]'', and it is active against both cysts and trophozoites that are localized in the lumen of the intestine. It is considered the drug of choice for treating asymptomatic or moderate forms of amebiasis. The mechanism of action is unknown. Iodoquinol is used for diseases caused by moderate intestinal amebiasis.
 ==References==
 {{reflist|2}}
-{{Agents against amoebozoa}}
-{{Excavata antiparasitics}}
 [[Category:Organoiodides]]
-[[Category:Quinolinols]]
 [[Category:Drug]]

Diiodohydroxyquinoline: Difference between revisions

Latest revision as of 13:39, 9 April 2015

Overview

References

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