Melevodopa: Difference between revisions

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Melevodopa
Clinical data
ATC code	N04BA04 (WHO) ;
Identifiers
	IUPAC name methyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate;
CAS Number	7101-51-1;
PubChem CID	23497;
ChemSpider	21968 ;
UNII	M30686U4X4;
KEGG	D07304 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C10H13NO4
Molar mass	211.215 g/mol
3D model (JSmol)	Interactive image;
	SMILES O=C(OC)[C@@H](N)Cc1cc(O)c(O)cc1;
	InChI InChI=1S/C10H13NO4/c1-15-10(14)7(11)4-6-2-3-8(12)9(13)5-6/h2-3,5,7,12-13H,4,11H2,1H3/t7-/m0/s1 ; Key:XBBDACCLCFWBSI-ZETCQYMHSA-N ;
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VisualWikitext

Latest revision as of 15:34, 9 April 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Melevodopa is a dopaminergic agent. It is the methyl ester of levodopa. It is used in tablet form as an effervescent prodrug with 250 times higher water solubility compared to tablet levodopa.^[1]

References

↑ Patrick Hickey and Mark Stacy (2011). "Available and emerging treatments for Parkinson's disease". Drug Des Devel Ther. 5: 241–254. doi:10.2147/DDDT.S11836. PMC 3096539. PMID 21607020.

Template:Phenethylamines

[1] Patrick Hickey and Mark Stacy (2011). "Available and emerging treatments for Parkinson's disease". Drug Des Devel Ther. 5: 241–254. doi:10.2147/DDDT.S11836. PMC 3096539. PMID 21607020.

[1]

@@ Line 1: / Line 1: @@
-{{drugbox
+{{Drugbox
-| IUPAC_name        = methyl (2''S'')-2-amino-3-(3,4-dihydroxyphenyl)propanoate
+| Watchedfields = changed
-| image             = Melevodopa.svg
+| verifiedrevid = 444522501
-| CAS_number        = 7101-51-1
+| IUPAC_name = methyl (2''S'')-2-amino-3-(3,4-dihydroxyphenyl)propanoate
-| ATC_prefix        = N04
+| image = Melevodopa.png
-| ATC_suffix        = BA04
-| PubChem           = 23497
+<!--Clinical data-->
-| DrugBank          =
+| tradename =
-| C=10|H=13|N=1|O=4
+| pregnancy_category =
-| molecular_weight  = 211.215 g/mol
+| legal_status =
-| bioavailability   =
+| routes_of_administration =
-| protein_bound     =
-| metabolism        =
+<!--Pharmacokinetic data-->
-| elimination_half-life =
+| bioavailability =
-| excretion         =
+| protein_bound =
-| pregnancy_AU      =  <!-- A / B1 / B2 / B3 / C / D / X -->
+| metabolism =
-| pregnancy_US      =  <!-- A / B            / C / D / X -->
+| elimination_half-life =
-| pregnancy_category=
+| excretion =
-| legal_AU          =  <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
-| legal_CA          =  <!--             / Schedule I, II, III, IV, V, VI, VII, VIII -->
+<!--Identifiers-->
-| legal_UK          =  <!-- GSL         / P       / POM / CD / Class A, B, C -->
+| CAS_number = 7101-51-1
-| legal_US          =  <!-- OTC                   / Rx-only  / Schedule I, II, III, IV, V -->
+| ATC_prefix = N04
-| legal_status      =
+| ATC_suffix = BA04
-| routes_of_administration =
+| PubChem = 23497
+| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
+| DrugBank =
+| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
+| ChemSpiderID = 21968
+| UNII_Ref = {{fdacite|correct|FDA}}
+| UNII = M30686U4X4
+| KEGG_Ref = {{keggcite|correct|kegg}}
+| KEGG = D07304
+<!--Chemical data-->
+| C=10 | H=13 | N=1 | O=4
+| molecular_weight = 211.215 g/mol
+| smiles = O=C(OC)[C@@H](N)Cc1cc(O)c(O)cc1
+| InChI = 1/C10H13NO4/c1-15-10(14)7(11)4-6-2-3-8(12)9(13)5-6/h2-3,5,7,12-13H,4,11H2,1H3/t7-/m0/s1
+| InChIKey = XBBDACCLCFWBSI-ZETCQYMHBU
+| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
+| StdInChI = 1S/C10H13NO4/c1-15-10(14)7(11)4-6-2-3-8(12)9(13)5-6/h2-3,5,7,12-13H,4,11H2,1H3/t7-/m0/s1
+| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
+| StdInChIKey = XBBDACCLCFWBSI-ZETCQYMHSA-N
 }}
-'''Melevodopa''' is a [[dopaminergic]] agent. It is the [[methyl]] [[ester]] of [[levodopa]].
+              __NOTOC__
+{{SI}}
+{{CMG}}
+==Overview==
+'''Melevodopa''' is a [[dopaminergic]] agent. It is the [[methyl]] [[ester]] of [[levodopa]]. It is used in tablet form as an effervescent prodrug with 250 times higher water solubility compared to tablet levodopa.<ref>{{cite journal |title = Available and emerging treatments for Parkinson’s disease |author = Patrick Hickey and Mark Stacy |journal = Drug Des Devel Ther |year = 2011 |volume = 5 |pages = 241–254 |doi = 10.2147/DDDT.S11836 |pmc = 3096539 |url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096539/ |pmid=21607020}}</ref>
+== See also ==
+* [[Etilevodopa]]
+== References ==
+{{Reflist|2}}
+{{Phenethylamines}}
-{{Dopaminergic agents}}
-[[Category:Antiparkinsonian agents]]
+[[Category:Drug]]
-[[Category:Prodrugs]]
+[[Category:Dopamine agonists]]
-{{WikiDoc Sources}}
+[[Category:Catecholamines]]
+[[Category:Propionates]]

Clinical data

ATC code	N04BA04 (WHO)
Identifiers
IUPAC name methyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate
CAS Number	7101-51-1
PubChem CID	23497
ChemSpider	21968^Y
UNII	M30686U4X4
KEGG	D07304^Y
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₁₀H₁₃NO₄
Molar mass	211.215 g/mol
3D model (JSmol)	Interactive image
SMILES O=C(OC)[C@@H](N)Cc1cc(O)c(O)cc1
InChI InChI=1S/C10H13NO4/c1-15-10(14)7(11)4-6-2-3-8(12)9(13)5-6/h2-3,5,7,12-13H,4,11H2,1H3/t7-/m0/s1^Y Key:XBBDACCLCFWBSI-ZETCQYMHSA-N^Y
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Melevodopa: Difference between revisions

Latest revision as of 15:34, 9 April 2015

Overview

See also

References

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