Ceftiofur: Difference between revisions

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Ceftiofur
Clinical data
AHFS/Drugs.com	International Drug Names
ATCvet code	Template:Infobox drug/formatATCvet; Template:Infobox drug/formatATCvet;
Identifiers
	IUPAC name (6R,7R)-7-[ [(2Z)-2-(2-Amino-1,3-thiazol-4-yl)- 2-methoxyiminoacetyl]amino]-3-(furan-2- carbonylsulfanylmethyl)-8-oxo-5-thia-1- azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;
CAS Number	80370-57-6 ;
PubChem CID	6328657;
ChemSpider	4886668 ;
UNII	83JL932I1C;
KEGG	D07657 ;
ChEMBL	ChEMBL222913 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C19H17N5O7S3
Molar mass	523.56 g/mol
3D model (JSmol)	Interactive image;
	SMILES O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)C(=N\OC)/c3nc(sc3)N)CSC(=O)c4occc4)C(=O)O;
	InChI InChI=1S/C19H17N5O7S3/c1-30-23-11(9-7-34-19(20)21-9)14(25)22-12-15(26)24-13(17(27)28)8(5-32-16(12)24)6-33-18(29)10-3-2-4-31-10/h2-4,7,12,16H,5-6H2,1H3,(H2,20,21)(H,22,25)(H,27,28)/b23-11-/t12-,16-/m1/s1 ; Key:ZBHXIWJRIFEVQY-IHMPYVIRSA-N ;
(verify)

← Older edit

VisualWikitext

Latest revision as of 13:26, 10 April 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Ceftiofur is an antibiotic of the cephalosporin type (third generation), licensed for use in veterinary medicine. It was first described in 1987.^[1] It is marketed by pharmaceutical company Pfizer as Excede.^[2]

It is resistant to the antibiotic resistance enzyme beta-lactamase, and has activity against Gram-positive and Gram-negative bacteria. E. coli strains resistant to ceftiofur have been reported.^[3]

References

↑ Yancey RJ, Kinney ML, Roberts BJ, Goodenough KR, Hamel JC, Ford CW (1987). "Ceftiofur sodium, a broad-spectrum cephalosporin: evaluation in vitro and in vivo in mice". Am. J. Vet. Res. 48 (7): 1050–3. PMID 3631686.
↑ "Pfizer Animal ealth Dairy Information on Products and Solutions". Retrieved 2007-11-20.
↑ Donaldson SC, Straley BA, Hegde NV, Sawant AA, DebRoy C, Jayarao BM (2006). "Molecular epidemiology of ceftiofur-resistant Escherichia coli isolates from dairy calves". Appl. Environ. Microbiol. 72 (6): 3940–8. doi:10.1128/AEM.02770-05. PMID 16751500.

External links

Official website

Template:WH Template:WS

[1] Yancey RJ, Kinney ML, Roberts BJ, Goodenough KR, Hamel JC, Ford CW (1987). "Ceftiofur sodium, a broad-spectrum cephalosporin: evaluation in vitro and in vivo in mice". Am. J. Vet. Res. 48 (7): 1050–3. PMID 3631686.

[2] "Pfizer Animal ealth Dairy Information on Products and Solutions". Retrieved 2007-11-20.

[3] Donaldson SC, Straley BA, Hegde NV, Sawant AA, DebRoy C, Jayarao BM (2006). "Molecular epidemiology of ceftiofur-resistant Escherichia coli isolates from dairy calves". Appl. Environ. Microbiol. 72 (6): 3940–8. doi:10.1128/AEM.02770-05. PMID 16751500.

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
 {{Drugbox
-| IUPAC_name        = (6''R'',7''R'')-7-[ [(2''Z'')-2-(2-Amino-1,3-thiazol-4-yl)- 2-methoxyiminoacetyl]amino]-3-(furan-2- carbonylsulfanylmethyl)-8-oxo-5-thia-1- azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
+| Watchedfields = changed
-| image             =Ceftiofur.png
+| verifiedrevid = 443443988
-| CAS_number        = 80370-57-6
+| IUPAC_name = (6''R'',7''R'')-7-[ [(2''Z'')-2-(2-Amino-1,3-thiazol-4-yl)- 2-methoxyiminoacetyl]amino]-3-(furan-2- carbonylsulfanylmethyl)-8-oxo-5-thia-1- azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
-| ATC_prefix        =
+| image =Ceftiofur.png
-| ATC_suffix        =
-| PubChem           =
+<!--Clinical data-->
-| DrugBank          =
+| tradename =
-| C=19|H=17|N=5|O=7|S=3
+| Drugs.com = {{drugs.com|international|ceftiofur}}
-| molecular_weight  = 523.56 g/mol
+| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
-| bioavailability   =
+| pregnancy_US = <!-- A / B            / C / D / X -->
-| protein_bound     =
+| pregnancy_category =
-| metabolism        =
+| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
-| elimination_half-life =
+| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
-| excretion         =
+| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
-| pregnancy_AU      =  <!-- A / B1 / B2 / B3 / C / D / X -->
+| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
-| pregnancy_US      =  <!-- A / B            / C / D / X -->
+| legal_status =
-| pregnancy_category=
+| routes_of_administration =
-| legal_AU =  <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
-| legal_CA =  <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
+<!--Pharmacokinetic data-->
-| legal_UK =  <!-- GSL, P, POM, CD, or Class A, B, C -->
+| bioavailability =
-| legal_US =  <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
+| protein_bound =
-| legal_status      =
+| metabolism =
-| routes_of_administration =
+| elimination_half-life =
+| excretion =
+<!--Identifiers-->
+| CAS_number_Ref = {{cascite|correct|??}}
+| CAS_number = 80370-57-6
+| ATCvet = yes
+| ATC_prefix = J01
+| ATC_suffix = DD90
+| ATC_supplemental = {{ATCvet|J51|DD90}}
+| PubChem = 6328657
+| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
+| DrugBank =
+| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
+| ChemSpiderID = 4886668
+| UNII_Ref = {{fdacite|correct|FDA}}
+| UNII = 83JL932I1C
+| KEGG_Ref = {{keggcite|correct|kegg}}
+| KEGG = D07657
+| ChEMBL_Ref = {{ebicite|correct|EBI}}
+| ChEMBL = 222913
+<!--Chemical data-->
+| C=19 | H=17 | N=5 | O=7 | S=3
+| molecular_weight = 523.56 g/mol
+| smiles = O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)C(=N\OC)/c3nc(sc3)N)CSC(=O)c4occc4)C(=O)O
+| InChI = 1/C19H17N5O7S3/c1-30-23-11(9-7-34-19(20)21-9)14(25)22-12-15(26)24-13(17(27)28)8(5-32-16(12)24)6-33-18(29)10-3-2-4-31-10/h2-4,7,12,16H,5-6H2,1H3,(H2,20,21)(H,22,25)(H,27,28)/b23-11-/t12-,16-/m1/s1
+| InChIKey = ZBHXIWJRIFEVQY-IHMPYVIRBM
+| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
+| StdInChI = 1S/C19H17N5O7S3/c1-30-23-11(9-7-34-19(20)21-9)14(25)22-12-15(26)24-13(17(27)28)8(5-32-16(12)24)6-33-18(29)10-3-2-4-31-10/h2-4,7,12,16H,5-6H2,1H3,(H2,20,21)(H,22,25)(H,27,28)/b23-11-/t12-,16-/m1/s1
+| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
+| StdInChIKey = ZBHXIWJRIFEVQY-IHMPYVIRSA-N
+}}
 __Notoc__
 {{SI}}

Ceftiofur: Difference between revisions

Latest revision as of 13:26, 10 April 2015

Overview

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