Azatadine: Difference between revisions
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{{ | {{Drugbox | ||
| verifiedrevid = 477164914 | |||
| IUPAC_name = 11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-<br>5''H''-benzo[5,6]cyclohepta[1,2-b]pyridine | | IUPAC_name = 11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-<br>5''H''-benzo[5,6]cyclohepta[1,2-b]pyridine | ||
| image = | | image =Azatadine.png | ||
<!--Clinical data--> | |||
| tradename = Optimine | |||
| Drugs.com = {{drugs.com|CONS|azatadine}} | |||
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> | |||
| pregnancy_US = B | |||
| legal_AU = <!-- Unscheduled / S2 / S4 / S8 --> | |||
| legal_UK = <!-- GSL / P / POM / CD --> | |||
| legal_US = Rx-only | |||
<!--Identifiers--> | |||
| CASNo_Ref = {{cascite|correct|CAS}} | |||
| CAS_number_Ref = {{cascite|correct|??}} | |||
| CAS_number = 3964-81-6 | | CAS_number = 3964-81-6 | ||
| ATC_prefix = R06 | | ATC_prefix = R06 | ||
| ATC_suffix = AX09 | | ATC_suffix = AX09 | ||
| PubChem = 19861 | | PubChem = 19861 | ||
| DrugBank = | | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | ||
| C=20 | H=22 | N=2 | | DrugBank = DB00719 | ||
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | |||
| ChemSpiderID = 18709 | |||
| UNII_Ref = {{fdacite|correct|FDA}} | |||
| UNII = 94Z39NID6C | |||
| KEGG_Ref = {{keggcite|correct|kegg}} | |||
| KEGG = D07482 | |||
| ChEBI_Ref = {{ebicite|correct|EBI}} | |||
| ChEBI = 2946 | |||
| ChEMBL_Ref = {{ebicite|correct|EBI}} | |||
| ChEMBL = 946 | |||
<!--Chemical data--> | |||
| C=20 | H=22 | N=2 | |||
| molecular_weight = 290.402 g/mol | | molecular_weight = 290.402 g/mol | ||
| | | smiles = n4c3\C(=C1/CCN(C)CC1)c2ccccc2CCc3ccc4 | ||
| | | InChI = 1/C20H22N2/c1-22-13-10-16(11-14-22)19-18-7-3-2-5-15(18)8-9-17-6-4-12-21-20(17)19/h2-7,12H,8-11,13-14H2,1H3 | ||
| | | InChIKey = SEBMTIQKRHYNIT-UHFFFAOYAF | ||
| | | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | ||
| | | StdInChI = 1S/C20H22N2/c1-22-13-10-16(11-14-22)19-18-7-3-2-5-15(18)8-9-17-6-4-12-21-20(17)19/h2-7,12H,8-11,13-14H2,1H3 | ||
| | | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | ||
| StdInChIKey = SEBMTIQKRHYNIT-UHFFFAOYSA-N | |||
| | |||
| | |||
}} | }} | ||
__Notoc__ | |||
{{SI}} | |||
{{CMG}} | |||
==Overview== | |||
'''Azatadine''' ('''Optimine''') is a [[first-generation antihistamine]] and [[anticholinergic]] that was launched [[Schering-Plough]] in 1973.<ref>{{cite pmid|8795241}}</ref><ref>{{cite pmid|1982614}}</ref><ref>{{cite pmid|1968324}}</ref> | |||
It was patented in 1967.<ref>Azatadine, Villani, F. J.; Caldwell, W. {{US patent|3326924}} (1967).</ref> | |||
*It is a predecessor to [[loratidine]], albeit lacking the chlorine atom. Also, it is N-methyl instead of carboethoxyamido. | |||
== See also == | |||
* [[Benzocycloheptenes]] | |||
== | == References == | ||
{{Reflist|2}} | |||
{{Antihistamines}} | {{Antihistamines}} | ||
[[Category:Piperidines]] | |||
[[Category:H1 receptor antagonists]] | |||
[[Category:Drug]] | |||
Latest revision as of 12:57, 13 April 2015
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| Clinical data | |
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| Trade names | Optimine |
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
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| Legal status | |
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| Identifiers | |
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| PubChem CID | |
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| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C20H22N2 |
| Molar mass | 290.402 g/mol |
| 3D model (JSmol) | |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Azatadine (Optimine) is a first-generation antihistamine and anticholinergic that was launched Schering-Plough in 1973.[1][2][3]
It was patented in 1967.[4]
- It is a predecessor to loratidine, albeit lacking the chlorine atom. Also, it is N-methyl instead of carboethoxyamido.
See also
References
- ↑ PMID 8795241 (PMID 8795241)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand - ↑ PMID 1982614 (PMID 1982614)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand - ↑ PMID 1968324 (PMID 1968324)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand - ↑ Azatadine, Villani, F. J.; Caldwell, W. U.S. Patent 3,326,924 (1967).