Desoxycorticosterone: Difference between revisions
m Protected "Desoxycorticosterone": Protecting pages from unwanted edits ([edit=sysop] (indefinite) [move=sysop] (indefinite)) |
Rabin Bista (talk | contribs) No edit summary |
||
| (One intermediate revision by one other user not shown) | |||
| Line 23: | Line 23: | ||
| routes_of_administration = | | routes_of_administration = | ||
}} | }} | ||
{{ | __NOTOC__ | ||
{{SI}} | |||
{{CMG}} | |||
== Overview == | |||
'''Desoxycorticosterone''' (11-deoxycorticosterone) is a [[mineralocorticoid]] secreted from [[Zona reticularis]] and [[Zona fasciculata]] of the [[adrenal gland]]. In the [[cytosol]] of the [[mitochondrion]], [[pregnenolone]] is converted to either androgens or 11-deoxycorticosterone and 11-deoxycortisol by enzymes of the [[endoplasmic reticulum]]. Then, 11-deoxycorticosterone, along with 11-deoxycortisol, re-enters the mitochondrion, where the enzymes are located for tissue-specific conversion to mineralocorticoids or glucocorticoids, respectively. | '''Desoxycorticosterone''' (11-deoxycorticosterone) is a [[mineralocorticoid]] secreted from [[Zona reticularis]] and [[Zona fasciculata]] of the [[adrenal gland]]. In the [[cytosol]] of the [[mitochondrion]], [[pregnenolone]] is converted to either androgens or 11-deoxycorticosterone and 11-deoxycortisol by enzymes of the [[endoplasmic reticulum]]. Then, 11-deoxycorticosterone, along with 11-deoxycortisol, re-enters the mitochondrion, where the enzymes are located for tissue-specific conversion to mineralocorticoids or glucocorticoids, respectively. | ||
| Line 31: | Line 34: | ||
==References== | ==References== | ||
{{Reflist|2}} | |||
http://web.indstate.edu/thcme/mwking/steroid-hormones.html | http://web.indstate.edu/thcme/mwking/steroid-hormones.html | ||
[[Category:drug]] | |||
[[Category:Mineralocorticoids]] | [[Category:Mineralocorticoids]] | ||
Latest revision as of 16:06, 14 April 2015
| Error creating thumbnail: File missing | |
| Clinical data | |
|---|---|
| ATC code | |
| Identifiers | |
| CAS Number | |
| PubChem CID | |
| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C21H30O4 |
| Molar mass | 330.461 |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Desoxycorticosterone (11-deoxycorticosterone) is a mineralocorticoid secreted from Zona reticularis and Zona fasciculata of the adrenal gland. In the cytosol of the mitochondrion, pregnenolone is converted to either androgens or 11-deoxycorticosterone and 11-deoxycortisol by enzymes of the endoplasmic reticulum. Then, 11-deoxycorticosterone, along with 11-deoxycortisol, re-enters the mitochondrion, where the enzymes are located for tissue-specific conversion to mineralocorticoids or glucocorticoids, respectively.
Desoxycorticosterone is commonly found in two forms: the acetate salt (desoxycorticosterone acetate, or DOCA) and the pivalate salt (desoxycorticosterone pivalate). Both forms are given as intramuscular injections as replacement therapy for Addison's disease. This disease is marked by insufficient adrenal function, including low mineralocorticoid levels.
Desoxycorticosterone pivalate is sold for veterinary use by Novartis under the brand name Percoten.
References
http://web.indstate.edu/thcme/mwking/steroid-hormones.html
Template:Corticosteroids Template:Corticosteroids for systemic use Template:Jb1 Template:WH Template:WS
- Pages with script errors
- E number from Wikidata
- ECHA InfoCard ID from Wikidata
- Chemical articles with unknown parameter in Infobox drug
- Articles without EBI source
- Chemical pages without ChemSpiderID
- Chemical pages without DrugBank identifier
- Articles without KEGG source
- Articles without InChI source
- Articles without UNII source
- Drugs with no legal status
- Articles containing unverified chemical infoboxes
- Drug
- Mineralocorticoids