Desoxycorticosterone: Difference between revisions
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== Overview == | |||
'''Desoxycorticosterone''' (11-deoxycorticosterone) is a [[mineralocorticoid]] secreted from [[Zona reticularis]] and [[Zona fasciculata]] of the [[adrenal gland]]. In the [[cytosol]] of the [[mitochondrion]], [[pregnenolone]] is converted to either androgens or 11-deoxycorticosterone and 11-deoxycortisol by enzymes of the [[endoplasmic reticulum]]. Then, 11-deoxycorticosterone, along with 11-deoxycortisol, re-enters the mitochondrion, where the enzymes are located for tissue-specific conversion to mineralocorticoids or glucocorticoids, respectively. | '''Desoxycorticosterone''' (11-deoxycorticosterone) is a [[mineralocorticoid]] secreted from [[Zona reticularis]] and [[Zona fasciculata]] of the [[adrenal gland]]. In the [[cytosol]] of the [[mitochondrion]], [[pregnenolone]] is converted to either androgens or 11-deoxycorticosterone and 11-deoxycortisol by enzymes of the [[endoplasmic reticulum]]. Then, 11-deoxycorticosterone, along with 11-deoxycortisol, re-enters the mitochondrion, where the enzymes are located for tissue-specific conversion to mineralocorticoids or glucocorticoids, respectively. | ||
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==References== | ==References== | ||
{{Reflist|2}} | |||
http://web.indstate.edu/thcme/mwking/steroid-hormones.html | http://web.indstate.edu/thcme/mwking/steroid-hormones.html | ||
[[Category:drug]] | |||
[[Category:Mineralocorticoids]] | [[Category:Mineralocorticoids]] | ||
Latest revision as of 16:06, 14 April 2015
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| Clinical data | |
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| ATC code | |
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| PubChem CID | |
| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C21H30O4 |
| Molar mass | 330.461 |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Desoxycorticosterone (11-deoxycorticosterone) is a mineralocorticoid secreted from Zona reticularis and Zona fasciculata of the adrenal gland. In the cytosol of the mitochondrion, pregnenolone is converted to either androgens or 11-deoxycorticosterone and 11-deoxycortisol by enzymes of the endoplasmic reticulum. Then, 11-deoxycorticosterone, along with 11-deoxycortisol, re-enters the mitochondrion, where the enzymes are located for tissue-specific conversion to mineralocorticoids or glucocorticoids, respectively.
Desoxycorticosterone is commonly found in two forms: the acetate salt (desoxycorticosterone acetate, or DOCA) and the pivalate salt (desoxycorticosterone pivalate). Both forms are given as intramuscular injections as replacement therapy for Addison's disease. This disease is marked by insufficient adrenal function, including low mineralocorticoid levels.
Desoxycorticosterone pivalate is sold for veterinary use by Novartis under the brand name Percoten.
References
http://web.indstate.edu/thcme/mwking/steroid-hormones.html
Template:Corticosteroids Template:Corticosteroids for systemic use Template:Jb1 Template:WH Template:WS
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- Drug
- Mineralocorticoids