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| {{Drugbox
| | #REDIRECT [[Tricaine mesylate]] |
| | Verifiedfields = changed
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| | Watchedfields = changed
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| | verifiedrevid = 455329821
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| | IUPAC_name = Ethyl 3-aminobenzoate methanesulfonic acid
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| | image = tricaine.png
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| <!--Clinical data-->
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| | tradename =
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| | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
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| | pregnancy_US = <!-- A / B / C / D / X -->
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| | pregnancy_category =
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| | legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
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| | legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
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| | legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
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| | legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
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| | legal_status =
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| | routes_of_administration =
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| <!--Pharmacokinetic data-->
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| | bioavailability =
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| | protein_bound =
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| | metabolism =
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| | elimination_half-life =
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| | excretion =
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| <!--Identifiers-->
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| | CAS_number_Ref = {{cascite|correct|??}}
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| | CAS_number = 886-86-2
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| | CAS_supplemental =
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| | ATCvet = yes
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| | ATC_prefix = N01
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| | ATC_suffix = AX93
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| | ATC_supplemental =
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| | DrugBank_Ref = {{drugbankcite|correct|drugbank}}
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| | DrugBank =
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| | PubChem = 13454
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| | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
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| | ChemSpiderID = 12878
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| | InChI = 1/C9H11NO2.CH4O3S/c1-2-12-9(11)7-4-3-5-8(10)6-7;1-5(2,3)4/h3-6H,2,10H2,1H3;1H3,(H,2,3,4)
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| | InChIKey = FQZJYWMRQDKBQN-UHFFFAOYAO
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| | StdInChI_Ref = {{stdinchicite|changed|chemspider}}
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| | StdInChI = 1S/C9H11NO2.CH4O3S/c1-2-12-9(11)7-4-3-5-8(10)6-7;1-5(2,3)4/h3-6H,2,10H2,1H3;1H3,(H,2,3,4)
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| | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}
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| | StdInChIKey = FQZJYWMRQDKBQN-UHFFFAOYSA-N
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| | |
| <!--Chemical data-->
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| | chemical_formula =
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| | C=10 | H=15 | N=1 | O=5 | S=1
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| | molecular_weight = 261.296 g/mol
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| | smiles = [NH3+]C1=CC=CC(C(OCC)=O)=C1.CS(=O)([O-])=O
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| | synonyms = Metacaine<br />Tricaine<br />MS-222<br />Finquel<br />TMS
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| | melting_point = 149.5
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| }}
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| '''Tricaine mesylate''' ('''Tricaine methanesulfonate''', '''TMS''', '''MS-222'''), is white powder used for [[anesthesia]], sedation, or [[euthanasia]] of fish. TMS is the only anesthetic licensed in the United States for fin fish that are intended for human consumption.
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| The drug can have selective toxicity for [[poikilotherm]]s due to their lower rate of metabolism in the liver.<ref>Wayson KA(1976)."Studies on the comparative pharmacology and selective toxicity of tricaine methanesulfonate: metabolism as a basis of the selectivity toxicity in poikilotherms."''J Pharmacol Exp Ther'''''198'''(3):695-708. [PMID 185356]</ref>
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| TMS is a [[muscle relaxant]] that operates by preventing [[action potential]]s. {{citation needed|date=February 2013}}By blocking action potentials, no signals can be exchanged between the [[brain]] and the extremities. There will be no [[sensory input]] or [[muscle contraction]]s which would have been caused by action potential, which includes most muscles.
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| The optimum concentration may vary with the size and species of the fish, and other variables.
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| It is easily soluble in water (both fresh and salt) but it drastically decreases the [[pH]] of water, increasing the acidity, which may be toxic for fish. [[Sodium bicarbonate]] can be used to buffer the solution to a pH range of 6.5-7.5. Usually an equal amount of buffer is added to attain a neutral pH.<ref>http://www.research.cornell.edu/care/documents/ACUPs/ACUP306.pdf</ref> In salt/marine/sea water, the buffer use may not be necessary because sea water itself has buffering capacity.
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| The solution of TMS needs to be prepared freshly each time because TMS is light-sensitive and might form toxic by-products upon exposure to light.
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| ==References==
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| <references/>
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| {{DEFAULTSORT:Tricaine Mesylate}}
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| [[Category:General anesthetics]]
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| [[Category:Benzoates]]
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