Diloxanide furoate: Difference between revisions

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Diloxanide
Clinical data
Trade names	Furamide
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy; category	No available data;
Routes of; administration	Oral
ATC code	P01AC01 (WHO) ;
Legal status
Legal status	Not approved (US, CA);
Pharmacokinetic data
Bioavailability	90% (diloxanide)
Metabolism	Hydrolyzed to furoic acid and diloxanide, which undergoes extensive glucuronidation
Elimination half-life	3 hours
Excretion	Renal (90%), fecal (10%)
Identifiers
	IUPAC name 4-[(dichloroacetyl)(methyl)amino]phenyl furan-2-carboxylate;
CAS Number	3736-81-0 ;
PubChem CID	19529;
DrugBank	DB08792 ;
ChemSpider	18400 ;
KEGG	D02480 ;
ChEMBL	ChEMBL1334860 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C14H11Cl2NO4
Molar mass	328.147 g/mol
3D model (JSmol)	Interactive image;
	SMILES O=C(Oc1ccc(N(C(=O)C(Cl)Cl)C)cc1)c2occc2;
	InChI InChI=1S/C14H11Cl2NO4/c1-17(13(18)12(15)16)9-4-6-10(7-5-9)21-14(19)11-3-2-8-20-11/h2-8,12H,1H3 ; Key:BDYYDXJSHYEDGB-UHFFFAOYSA-N ;
(what is this?) (verify)

VisualWikitext

Latest revision as of 13:04, 23 April 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Diloxanide furoate is a luminal amebicide used in the treatment of Amebiasis. It is considered the luminal agent of choice for mild intestinal amebiasis or asymptomatic cyst carriers.It can also be added to metronidazole(active drug in luminal and extraintestinal amebiasis) in acute amebic dysentery as well as hepatic abscess(In hepatic abscess it is for the control of cysts in the lumen which may cause relapse). The drug was discovered by The Boots Company Plc in 1956 and introduced as Furamide. The Furamide brand is now owned by Abbott Laboratories. It is not available in the US. In India it is available as Amicline by Franco-Indian.

It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.

Safety and effectiveness

A 13-year study conducted by the United States Center for Disease Control between 1977 and 1990 found that this drug had a low incidence of side effects and was successful in treatment of 86% of asymptomatic carriers of Entamoeba histolytica.

References

@@ Line 1: / Line 1: @@
-{{SI}}
+{{Drugbox
+| Verifiedfields = changed
+| verifiedrevid = 470454750
+| IUPAC_name = 4-[(dichloroacetyl)(methyl)amino]phenyl furan-2-carboxylate
+| image = Diloxanide furoate.png
+| drug_name = Diloxanide
+<!--Clinical data-->
+| tradename = Furamide
+| Drugs.com = {{drugs.com|CONS|diloxanide}}
+| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
+| pregnancy_US = <!-- A / B            / C / D / X -->
+| pregnancy_category = No available data
+| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
+| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
+| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
+| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
+| legal_status = Not approved <small>([[United States|US]], [[Canada|CA]])</small>
+| routes_of_administration = Oral
-{{EH}}
+<!--Pharmacokinetic data-->
+| bioavailability = 90% (diloxanide)
+| protein_bound =
+| metabolism = [[hydrolysis|Hydrolyzed]] to furoic acid and diloxanide, which undergoes extensive [[glucuronidation]]
+| elimination_half-life = 3 hours
+| excretion = [[Kidney|Renal]] (90%), fecal (10%)
-'''Diloxanide furoate''' is an anti-protozoal drug used in the treatment of [[Entamoeba histolytica]] and some other protozoal infections.
+<!--Identifiers-->
+| CAS_number_Ref = {{cascite|changed|??}}
+| CAS_number = 3736-81-0
+| ATC_prefix = P01
+| ATC_suffix = AC01
+| PubChem = 19529
+| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
+| DrugBank = DB08792
+| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
+| ChemSpiderID = 18400
+| KEGG_Ref = {{keggcite|correct|kegg}}
+| KEGG = D02480
+| ChEMBL_Ref = {{ebicite|changed|EBI}}
+| ChEMBL = 1334860
-==Safety and Effectiveness==
+<!--Chemical data-->
-A 13-year study conducted by the United States [[Center for Disease Control]] between 1977 and 1990 found that this drug had a low incidence of side effects and was successful in treatment of 86% of asymptomatic carriers of ''[[Entamoeba histolytica]].''  <ref name="pmid1520794">{{cite journal |author=McAuley JB, Herwaldt BL, Stokes SL, ''et al'' |title=Diloxanide furoate for treating asymptomatic Entamoeba histolytica cyst passers: 14 years' experience in the United States |journal=Clin. Infect. Dis. |volume=15 |issue=3 |pages=464–8 |year=1992 |pmid=1520794 |doi=}}</ref>
+| C=14 | H=11 | Cl=2 | N=1 | O=4
+| molecular_weight = 328.147 g/mol
+| smiles = O=C(Oc1ccc(N(C(=O)C(Cl)Cl)C)cc1)c2occc2
+| InChI = 1/C14H11Cl2NO4/c1-17(13(18)12(15)16)9-4-6-10(7-5-9)21-14(19)11-3-2-8-20-11/h2-8,12H,1H3
+| InChIKey = BDYYDXJSHYEDGB-UHFFFAOYAB
+| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
+| StdInChI = 1S/C14H11Cl2NO4/c1-17(13(18)12(15)16)9-4-6-10(7-5-9)21-14(19)11-3-2-8-20-11/h2-8,12H,1H3
+| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
+| StdInChIKey = BDYYDXJSHYEDGB-UHFFFAOYSA-N
+}}
+__NOTOC__
+{{SI}}
+{{CMG}}
+==Overview==
+'''Diloxanide furoate''' is a luminal amebicide used in the treatment of ''[[Amebiasis]].'' It is considered the luminal agent of choice for mild intestinal amebiasis or asymptomatic cyst carriers.It can also be added to metronidazole(active drug in luminal and extraintestinal amebiasis) in acute amebic dysentery as well as hepatic abscess(In hepatic abscess it is for the control of cysts in the lumen which may cause relapse). The drug was discovered by ''The Boots Company Plc'' in 1956 and introduced as ''Furamide''. The ''Furamide'' brand is now owned by [[Abbott Laboratories]]. It is not available in the US. In India it is available as ''Amicline'' by ''Franco-Indian''.
-==Availability by Country==
+<!-- Society and culture -->
+It is on the [[World Health Organization's List of Essential Medicines]], a list of the most important medication needed in a basic [[health system]].
-'''United States''': Not currently approved for use.  A [[CDC]] study authorized the use of this drug in the treatment of 4,371 cases of ''[[Entamoeba histolytica]]'' from 1977 to 1990.  <ref name="pmid1520794" />
+==Safety and effectiveness==
+A 13-year study conducted by the United States [[Center for Disease Control]] between 1977 and 1990 found that this drug had a low incidence of side effects and was successful in treatment of 86% of asymptomatic carriers of ''[[Entamoeba histolytica]].''
 ==References==
-{{Reflist}}
+{{Reflist|2}}
-{{SIB}}
-[[Category:Drugs]]
-{{WikiDoc Help Menu}}
+[[Category:Antiprotozoal agents]]
-{{WikiDoc Sources}}
+[[Category:Drug]]

Diloxanide furoate: Difference between revisions

Latest revision as of 13:04, 23 April 2015

Overview

Safety and effectiveness

References

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