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| {{DrugProjectFormSinglePage | | {{Details0|Bacitracin (Injection)}} |
| |authorTag={{AP}}
| | {{Details0|Bacitracin (topical)}} |
| |genericName=Bacitracin | | {{Details0|Bacitracin (opthalmic)}} |
| |aOrAn=an
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| |drugClass=[[antibiotic]]
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| |indicationType=treatment
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| |indication=infants with [[pneumonia]] and [[empyema]] caused by [[staphylococci]] shown to be susceptible to the drug
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| |hasBlackBoxWarning=Yes
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| |adverseReactions=injection site pain
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| |blackBoxWarningTitle=WARNING
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| |blackBoxWarningBody=Nephrotoxicity: Bacitracin in parenteral (intramuscular) therapy may cause renal failure due to tubular and glomerular necrosis. Its use should be restricted to infants with staphylococcal pneumonia and empyema when due to organisms shown to be susceptible to bacitracin. It should be used only where adequate laboratory facilities are available and when constant supervision of the patient is possible. Renal function should be carefully determined prior to and daily during therapy. The recommended daily dose should not be exceeded and fluid intake and urinary output maintained at proper levels to avoid kidney toxicity. If renal toxicity occurs the drug should be discontinued. The concurrent use of other nephrotoxic drugs, particularly streptomycin, kanamycin, polymyxin B, polymyxin E (colistin), and neomycin should be avoided.
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| |offLabelAdultGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of Bacitracin in adult patients.
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| |offLabelAdultNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of Bacitracin in adult patients.
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| |offLabelPedGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of Bacitracin in pediatric patients.
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| |offLabelPedNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of Bacitracin in pediatric patients.
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| |alcohol=Alcohol-Bacitracin interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
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| }} | |
| __NOTOC__
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| {{Bacitracin}} | |
| {{CMG}}; {{AE}} {{MM}} | |
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| ==Overview==
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| '''Bacitracin''' is a mixture of related cyclic [[peptide|polypeptide]]s produced by [[organism]]s of the licheniformis group of ''[[Bacillus subtilis]]'' ''var'' Tracy. Its unique name derives from the fact that the bacillus producing it was first isolated in 1943 from a knee scrape from a girl named Margaret Tracy.<ref>Johnson B, Anker H, Meleney F (1945). "Bacitracin: a new antibiotic produced by a member of the B. subtilis group". ''[[Science (journal)|Science]]'' '''102''' (2650): 376–377.</ref> As a toxic and difficult-to-use [[antibiotic]], bacitracin doesn't work well orally. However, it is very effective topically.
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| Bacitracin is synthesised via the so-called nonribosomal peptide synthetases (NRPSs), which means that [[ribosome]]s are not involved in its [[nonribosomal peptide|synthesis]]. | |
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| ==Category==
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| [[Polypeptide]]
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| ==US Brand Names==
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| BACIIM<sup>®</sup>
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| ==FDA Package Insert==
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| '''[[Bacitracin description|Description]]'''
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| '''| [[Bacitracin clinical pharmacology|Clinical Pharmacology]]'''
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| '''| [[Bacitracin indications and usage|Indications and Usage]]'''
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| '''| [[Bacitracin contraindications|Contraindications]]'''
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| '''| [[Bacitracin warnings and precautions|Warnings and Precautions]]'''
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| '''| [[Bacitracin adverse reactions|Adverse Reactions]]'''
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| '''| [[Bacitracin dosage and administration|Dosage and Administration]]'''
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| '''| [[Bacitracin how supplied|How Supplied]]'''
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| ==Mechanism of Action==
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| Bacitracin interferes with the dephosphorylation of the [[carbon|C]]<sub>55</sub>-isoprenyl pyrophosphate, a molecule which carries the building blocks of the [[peptidoglycan]] bacterial [[cell wall]] outside of the inner membrane [http://www.pnas.org/cgi/content/abstract/68/12/3223].
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| ==References==
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| {{Reflist|2}}
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| [[Category:Antibiotics]]
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| [[Category:Wikinfect]]
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