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| {{DrugProjectFormSinglePage | | {{Details0|Bacitracin (Injection)}} |
| |authorTag={{AP}}
| | {{Details0|Bacitracin (topical)}} |
| |genericName=Bacitracin
| | {{Details0|Bacitracin (opthalmic)}} |
| |aOrAn=an
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| |drugClass=[[antibiotic]]
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| |indicationType=treatment
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| |indication=infants with [[pneumonia]] and [[empyema]] caused by [[staphylococci]] shown to be susceptible to the drug
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| |hasBlackBoxWarning=Yes
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| |adverseReactions=injection site pain
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| |blackBoxWarningTitle=WARNING | |
| |blackBoxWarningBody=Nephrotoxicity: Bacitracin in parenteral (intramuscular) therapy may cause renal failure due to tubular and glomerular necrosis. Its use should be restricted to infants with staphylococcal pneumonia and empyema when due to organisms shown to be susceptible to bacitracin. It should be used only where adequate laboratory facilities are available and when constant supervision of the patient is possible. Renal function should be carefully determined prior to and daily during therapy. The recommended daily dose should not be exceeded and fluid intake and urinary output maintained at proper levels to avoid kidney toxicity. If renal toxicity occurs the drug should be discontinued. The concurrent use of other nephrotoxic drugs, particularly streptomycin, kanamycin, polymyxin B, polymyxin E (colistin), and neomycin should be avoided.
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| |offLabelAdultGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of Bacitracin in adult patients.
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| |offLabelAdultNoGuideSupport======Pelvic Inflammatory Disease<ref name="pmid7417900">{{cite journal| author=Wright VC, Hatch LA, Lanning NM| title=Use of a topical triple-antibiotic spray to reduce morbidity from pelvic infection after gynecologic operations. | journal=Can J Surg | year= 1980 | volume= 23 | issue= 4 | pages= 366-9, 372 | pmid=7417900 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7417900 }} </ref>=====
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| |fdaLIADPed=Bacitracin is limited to the treatment of infants with pneumonia and empyema caused by staphylococci shown to be susceptible to the drug.To reduce the development of drug-resistant bacteria and maintain the effectiveness of Bacitracin and other antibacterial drugs, Bacitracin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
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| *Dosage:
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| **Infants under 2500 grams-900 units/kg/24 hours in 2 or 3 divided doses. For
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| **Infants over 2500 grams-1,000 units/kg/24 hours, in 2 or 3 divided doses.
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| Intramuscular injections of the solution should be given in the upper outer quadrant of the buttocks, alternating right and left and avoiding multiple injections in the same region because of the transient pain following injection.
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| ======Preparation of Solutions======
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| Should be dissolved in sodium chloride injection containing 2 percent procaine hydrochloride. The concentration of the antibiotic in the solution should not be less than 5,000 units per mL nor more than 10,000 units per mL. Diluents containing parabens should not be used to reconstitute bacitracin; cloudy solutions and precipitate formation have occurred. Reconstitution of the 50,000 unit vial with 9.8 mL of diluent will result in a concentration of 5,000 units per mL. Solutions are stable for one week when stored in a refrigerator 2° to 8°C (36° to 46°F).
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| |offLabelPedGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of Bacitracin in pediatric patients.
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| |offLabelPedNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of Bacitracin in pediatric patients. | |
| |contraindications=This drug is contraindicated in those individuals with a history of previous [[hypersensitivity]] or [[toxic reaction]] to it.
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| |warnings=[[Clostridium difficile associated diarrhea]] ([[CDAD]]) has been reported with use of nearly all [[antibacterial agents]], including Bacitracin for Injection and may range in severity from mild [[diarrhea]] to fatal [[colitis]]. Treatment with antibacterial agents alters the normal [[flora of the colon]] leading to overgrowth of [[C. difficile]].
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| [[C. difficile]] produces toxins A and B which contribute to the development of [[CDAD]]. Hypertoxin producing strains of [[C. difficile]] cause increased morbidity and mortality, as these infections can be refractory to antimicrobial therapy and may require [[colectomy]]. [[CDAD]] must be considered in all patients who present with diarrhea following antibiotic use. Careful medical history is necessary since [[CDAD]] has been reported to occur over two months after the administration of antibacterial agents.
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| If [[CDAD]] is suspected or confirmed, ongoing antibiotic use not directed against [[C. difficile]] may need to be discontinued. Appropriate fluid and [[electrolyte]] management, [[protein supplementation]], antibiotic treatment of [[C. difficile]], and surgical evaluation should be instituted as clinically indicated.
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| |alcohol=Alcohol-Bacitracin interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
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| }} | |