Dermatomyositis differential diagnosis: Difference between revisions
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==Overview== | ==Overview== | ||
Dermatomyositis must be differentiated from other common, lymphocyte predominant inflammatory myopathies. [[Hypothyroidism]] and [[sarcoidosis]] have some symptoms in common with dermatomyositis, and therefore need to be ruled out. | |||
==Differentiating Dermatomyositis from other Diseases== | ==Differentiating Dermatomyositis from other Diseases== | ||
Dermatomyositis must be differentiated from other common, lymphocyte predominant inflammatory myopathies. If present, the characteristic perifascicular atrophy makes this distinction trivial. | Dermatomyositis must be differentiated from other common, lymphocyte predominant inflammatory myopathies. If present, the characteristic perifascicular atrophy makes this distinction trivial. | ||
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There is some overlap in the microscopic appearances of different inflammatory myopathies, but some helpful differences are often present.{{Ref|Nirmalananthan2004}} The rimmed vacuoles of [[Inclusion body myositis|inclusion body myositis]] (IBM) are absent in dermatomyositis. Polymyositis is characterised by diffuse or patchy inflammation of the muscle fascicles, a random pattern of muscle atrophy, and T-cell predominance with T-cells seen invading otherwise viable appearing muscle fibers.{{Ref|Benveniste2004}} | There is some overlap in the microscopic appearances of different inflammatory myopathies, but some helpful differences are often present.{{Ref|Nirmalananthan2004}} The rimmed vacuoles of [[Inclusion body myositis|inclusion body myositis]] (IBM) are absent in dermatomyositis. Polymyositis is characterised by diffuse or patchy inflammation of the muscle fascicles, a random pattern of muscle atrophy, and T-cell predominance with T-cells seen invading otherwise viable appearing muscle fibers.{{Ref|Benveniste2004}} | ||
Diseases that can present with similar symptoms as those of dermatomyositis are- | |||
*[[Hypothyroidism]] | |||
*[[Sarcoidosis]] | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
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[[Category:Autoimmune diseases]] | [[Category:Autoimmune diseases]] | ||
[[Category:Rheumatology]] | [[Category:Rheumatology]] | ||
Latest revision as of 18:41, 3 June 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Dermatomyositis must be differentiated from other common, lymphocyte predominant inflammatory myopathies. Hypothyroidism and sarcoidosis have some symptoms in common with dermatomyositis, and therefore need to be ruled out.
Differentiating Dermatomyositis from other Diseases
Dermatomyositis must be differentiated from other common, lymphocyte predominant inflammatory myopathies. If present, the characteristic perifascicular atrophy makes this distinction trivial.
There is some overlap in the microscopic appearances of different inflammatory myopathies, but some helpful differences are often present.[2] The rimmed vacuoles of inclusion body myositis (IBM) are absent in dermatomyositis. Polymyositis is characterised by diffuse or patchy inflammation of the muscle fascicles, a random pattern of muscle atrophy, and T-cell predominance with T-cells seen invading otherwise viable appearing muscle fibers.[3]
Diseases that can present with similar symptoms as those of dermatomyositis are-