Low chylomicron remnant causes: Difference between revisions

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Latest revision as of 19:02, 9 June 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamed Moubarak, M.D. [2]

Overview

Low chylomicron remnant can be caused by various factors, with malabsorption and hyperthyroidism^[1] being the most common. Genetic, drug side effect, and gastroenterologic disease were also reported to cause low chylomicron remnant.

Low Chylomicron Remnant Causes

Life Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated. Low chylomicron remnant in itself is not a life threatening condition.

Common Causes

Causes by Organ System

Cardiovascular	No underlying causes
Chemical/Poisoning	No underlying causes
Dental	No underlying causes
Dermatologic	No underlying causes
Drug Side Effect	Lomitapide
Ear Nose Throat	No underlying causes
Endocrine	Hyperthyroidism
Environmental	No underlying causes
Gastroenterologic	Intestinal lymphangiectasia, malabsorption
Genetic	Abetalipoproteinemia^[2], chylomicron retention disease
Hematologic	No underlying causes
Iatrogenic	No underlying causes
Infectious Disease	No underlying causes
Musculoskeletal/Orthopedic	No underlying causes
Neurologic	No underlying causes
Nutritional/Metabolic	Malabsorption
Obstetric/Gynecologic	No underlying causes
Oncologic	No underlying causes
Ophthalmologic	No underlying causes
Overdose/Toxicity	No underlying causes
Psychiatric	No underlying causes
Pulmonary	No underlying causes
Renal/Electrolyte	No underlying causes
Rheumatology/Immunology/Allergy	No underlying causes
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Miscellaneous	No underlying causes

Causes by Alphabetical Order

References

↑ ^1.0 ^1.1 ^1.2 Weintraub M, Grosskopf I, Trostanesky Y, Charach G, Rubinstein A, Stern N (1999). "Thyroxine replacement therapy enhances clearance of chylomicron remnants in patients with hypothyroidism". J Clin Endocrinol Metab. 84 (7): 2532–6. PMID 10404832.
↑ ^2.0 ^2.1 ^2.2 Wetterau JR, Aggerbeck LP, Bouma ME, Eisenberg C, Munck A, Hermier M; et al. (1992). "Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia". Science. 258 (5084): 999–1001. PMID 1439810.

Template:WikiDoc Sources

[pmid10404832-1] 1.0 ^1.1 ^1.2 Weintraub M, Grosskopf I, Trostanesky Y, Charach G, Rubinstein A, Stern N (1999). "Thyroxine replacement therapy enhances clearance of chylomicron remnants in patients with hypothyroidism". J Clin Endocrinol Metab. 84 (7): 2532–6. PMID 10404832.

[pmid1439810-2] 2.0 ^2.1 ^2.2 Wetterau JR, Aggerbeck LP, Bouma ME, Eisenberg C, Munck A, Hermier M; et al. (1992). "Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia". Science. 258 (5084): 999–1001. PMID 1439810.

[1]

[2]

@@ Line 1: / Line 1: @@
 __NOTOC__
 {{Chylomicron remnant}}
-{{CMG}}
+{{CMG}}; {{AE}} {{MM}}
 ==Overview==
+Low chylomicron remnant can be caused by various factors, with [[malabsorption]] and [[hyperthyroidism]]<ref name="pmid10404832">{{cite journal| author=Weintraub M, Grosskopf I, Trostanesky Y, Charach G, Rubinstein A, Stern N| title=Thyroxine replacement therapy enhances clearance of chylomicron remnants in patients with hypothyroidism. | journal=J Clin Endocrinol Metab | year= 1999 | volume= 84 | issue= 7 | pages= 2532-6 | pmid=10404832 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10404832 }} </ref> being the most common. Genetic, drug side effect, and gastroenterologic disease were also reported to cause low chylomicron remnant.
 ==Low Chylomicron Remnant Causes==
@@ Line 11: / Line 12: @@
 ===Common Causes===
-*[[Abetalipoproteinemia]]
+*[[Abetalipoproteinemia]]<ref name="pmid1439810">{{cite journal| author=Wetterau JR, Aggerbeck LP, Bouma ME, Eisenberg C, Munck A, Hermier M et al.| title=Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia. | journal=Science | year= 1992 | volume= 258 | issue= 5084 | pages= 999-1001 | pmid=1439810 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1439810 }} </ref>
 *[[Chylomicron retention disease]]
+*[[Hyperthyroidism ]]<ref name="pmid10404832">{{cite journal| author=Weintraub M, Grosskopf I, Trostanesky Y, Charach G, Rubinstein A, Stern N| title=Thyroxine replacement therapy enhances clearance of chylomicron remnants in patients with hypothyroidism. | journal=J Clin Endocrinol Metab | year= 1999 | volume= 84 | issue= 7 | pages= 2532-6 | pmid=10404832 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10404832 }} </ref>
-*[[Hyperthyroidism ]]
 *[[Lymphangiectasia|Intestinal lymphangiectasia]]
-*[[Levothyroxine ]]
 *[[Lomitapide]]
+*[[Malabsorption]]
 ===Causes by Organ System===
@@ Line 41: / Line 37: @@
 |-bgcolor="LightSteelBlue"
 | '''Drug Side Effect'''
-|bgcolor="Beige"| [[Levothyroxine ]], [[lomitapide]]
+|bgcolor="Beige"|[[Lomitapide]]
 |-
 |-bgcolor="LightSteelBlue"
@@ Line 57: / Line 53: @@
 |-bgcolor="LightSteelBlue"
 | '''Gastroenterologic'''
-|bgcolor="Beige"| [[Lymphangiectasia|Intestinal lymphangiectasia]]
+|bgcolor="Beige"| [[Lymphangiectasia|Intestinal lymphangiectasia]], [[malabsorption]]
 |-
 |-bgcolor="LightSteelBlue"
 | '''Genetic'''
-|bgcolor="Beige"| [[Abetalipoproteinemia]], [[chylomicron retention disease]]
+|bgcolor="Beige"| [[Abetalipoproteinemia]]<ref name="pmid1439810">{{cite journal| author=Wetterau JR, Aggerbeck LP, Bouma ME, Eisenberg C, Munck A, Hermier M et al.| title=Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia. | journal=Science | year= 1992 | volume= 258 | issue= 5084 | pages= 999-1001 | pmid=1439810 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1439810 }} </ref>, [[chylomicron retention disease]]
 |-
 |-bgcolor="LightSteelBlue"
@@ Line 85: / Line 81: @@
 |-bgcolor="LightSteelBlue"
 | '''Nutritional/Metabolic'''
-|bgcolor="Beige"| No underlying causes
+|bgcolor="Beige"| [[Malabsorption]]
 |-
 |-bgcolor="LightSteelBlue"
@@ Line 138: / Line 134: @@
 ===Causes by Alphabetical Order===
-*[[Abetalipoproteinemia]]
+*[[Abetalipoproteinemia]]<ref name="pmid1439810">{{cite journal| author=Wetterau JR, Aggerbeck LP, Bouma ME, Eisenberg C, Munck A, Hermier M et al.| title=Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia. | journal=Science | year= 1992 | volume= 258 | issue= 5084 | pages= 999-1001 | pmid=1439810 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1439810 }} </ref>
 *[[Chylomicron retention disease]]
+*[[Hyperthyroidism ]]<ref name="pmid10404832">{{cite journal| author=Weintraub M, Grosskopf I, Trostanesky Y, Charach G, Rubinstein A, Stern N| title=Thyroxine replacement therapy enhances clearance of chylomicron remnants in patients with hypothyroidism. | journal=J Clin Endocrinol Metab | year= 1999 | volume= 84 | issue= 7 | pages= 2532-6 | pmid=10404832 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10404832 }} </ref>
-*[[Hyperthyroidism ]]
+*[[Lymphangiectasia|Intestinal lymphangiectasia]]
-*[[Intestinal lymphangiectasia]]
-*[[Levothyroxine ]]
 *[[Lomitapide]]
+*[[Malabsorption]]
 ==References==
@@ Line 159: / Line 150: @@
 [[Category:Cardiology]]
 [[Category:Lipoproteins]]
+[[Category:Up-To-Date]]
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v t e Lipopedia
Basic Science	Cholesterol • Triglyceride Lipoprotein metabolism and transport Lipoprotein: Chylomicron • Chylomicron remnant • HDL • IDL • LDL • Lipoprotein(a) • VLDL • Lipoprotein-X Apolipoprotein: APOA (1, 2, 4, 5) • APOB ( Apolipoprotein B-48, Apolipoprotein B-100) • APOC (1, 2, 3, 4) • APOD • APOE • APOH • APOJ • APOL • APOM • Apo(a) Lipoprotein receptor: LDL receptor • Soluble low density lipoprotein receptor-related protein (sLRP) • Apolipoprotein E Receptor 2 • Scavenger receptor • Scavenger receptor A • Scavenger receptor B • VLDL receptor Lipoprotein enzymes: Lipoprotein lipase • Lipoprotein-associated phospholipase A2 (Lp-PLA2) • Cholesterylester transfer protein ( Acetyl-CoA C-acyltransferase, Lecithin-cholesterol acyltransferase) • Microsomal triglyceride transfer protein • ABCA1 Genes: Low density lipoprotein receptor gene family • Microsomal triglyceride transfer protein • ABCA1
Lipoprotein Disorders	Lipoprotein disorders Primary lipoprotein disorders: Familial hyperchylomicronemia (Type I) • Familial hypercholesterolemia (Type IIA) • Familial combined hyperlipidemia (Type IIB) • Dysbetalipoproteinemia (Type III) • Primary hypertriglyceridemia (Type IV) • Mixed hyperlipoproteinemia (Type V) Secondary lipoprotein disorders
Abnormal Laboratory Lipid Profile	Low chylomicron • Low chylomicron remnant • Low HDL • Low IDL • Low LDL • Low lipoprotein(a) • Low VLDL High chylomicron • High chylomicron remnant • High HDL • High IDL • High LDL • High Lipoprotein(a) • High VLDL