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| __NOTOC__
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| {{Malaria}}
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| {{CMG}}
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| ==Overview==
| | #REDIRECT [[Plasmodium]] |
| Malaria is a [[Vector (biology)|vector]]-borne [[infectious disease]] caused by [[protozoan]] [[parasite]]s. Malaria is commonly associated with poverty, but is also a cause of poverty and a major hindrance to economic development.
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| [[Image:Malaria.jpg|thumb|left|250px|A ''Plasmodium'' sporozoite traverses the cytoplasm of a mosquito midgut epithelial cell in this false-color [[electron micrograph]].]]
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| ==Causes==
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| === Malaria Parasites ===
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| Malaria is caused by [[protozoa]]n [[parasite]]s of the genus ''[[Plasmodium]]'' (phylum [[Apicomplexa]]). In humans malaria is caused by ''[[Plasmodium falciparum|P. falciparum]]'', ''[[Plasmodium malariae|P. malariae]]'', ''[[Plasmodium ovale|P. ovale]]'', and ''[[Plasmodium vivax|P. vivax]]''. '' P. vivax'' is the most common cause of infection, responsible for about 80 % of all malaria cases. However, ''P. falciparum'' is the most important cause of disease, and responsible for about 15% of infections and 90% of deaths.<ref>{{cite journal | author = Mendis K, Sina B, Marchesini P, Carter R | title = The neglected burden of Plasmodium vivax malaria. | url=http://www.ajtmh.org/cgi/reprint/64/1_suppl/97.pdf | journal = Am J Trop Med Hyg | volume = 64 | issue = 1-2 Suppl | pages = 97-106 | year = 2001 | pmid = 11425182}}</ref> Parasitic ''Plasmodium'' species also infect birds, reptiles, monkeys, chimpanzees and rodents.<ref>{{cite journal | author = Escalante A, Ayala F | title = Phylogeny of the malarial genus Plasmodium, derived from rRNA gene sequences. | url=http://www.pnas.org/cgi/reprint/91/24/11373 | journal = Proc Natl Acad Sci U S A | volume = 91 | issue = 24 | pages = 11373-7 | year = 1994 | pmid = 7972067}}</ref> There have been documented human infections with several [[Wiktionary:simian|simian]] species of malaria, namely ''[[Plasmodium knowlesi|P. knowlesi]]'', ''P. inui'', ''P. cynomolgi''<ref>{{cite book | last=Garnham | first=PCC | date=1966 | title=Malaria parasites and other haemosporidia | publisher=Blackwell Scientific Publications|Location=Oxford }}</ref>, ''P. simiovale'', ''P. brazilianum'', ''P. schwetzi'' and ''P. simium''; however these are mostly of limited public health importance. Although avian malaria can kill chickens and turkeys, this disease does not cause serious economic losses to poultry farmers.<ref>Investing in Animal Health Research to Alleviate Poverty. International Livestock Research Institute. Permin A. and Madsen M. (2001) [http://www.ilri.cgiar.org/InfoServ/Webpub/fulldocs/investinginanimal/Book1/media/PDF_Appendix/Appendix8.pdfLiterature Appendix 2: review on disease occurrence and impact (smallholder poultry)]. Accessed 29 Oct 2006</ref> However, since being accidentally introduced by humans it has decimated the endemic birds of Hawaii, which evolved in its absence and lack any resistance to it.<ref>{{cite journal |author=Atkinson CT, Woods KL, Dusek RJ, Sileo LS, Iko WM |title=Wildlife disease and conservation in Hawaii: pathogenicity of avian malaria (''Plasmodium relictum'') in experimentally infected iiwi (''Vestiaria coccinea'') |journal=Parasitology |volume=111 Suppl |issue= |pages=S59-69 |year=1995 |pmid=8632925 |doi=}}</ref>
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| ==References==
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| {{reflist|3}}
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