Acute monocytic leukemia pathophysiology: Difference between revisions
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{{Acute monocytic leukemia}} | {{Acute monocytic leukemia}} | ||
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==Overview== | |||
==Pathophysiology== | |||
===Genetics=== | |||
M5 is associated with characteristic chromosomal abnormalities, often involving 11q23 or t(9;11)affecting the MLL locus, however the MLL translocation is also found in other AML subtypes. MLL is believed to be prognostically unfavorable in AML-M5 compared to other genetic alterations involving MLL such as t(9;11) The t(8;16) translocation in MLL is associated with hemophagocytosis. | |||
===Immunology=== | |||
Immunophenotypically, M5-AML variably express myeloid ([[CD13]], [[CD33]]) and monocytic ([[CD11b]], [[CD11c]]) markers. Cells may aberrantly express B cells marker [[CD20]] and the NK marker [[CD56]]. Monoblasts may be positive for [[CD34]]. | |||
==Risk Factors== | |||
AML-M5 is thought to be associated with exposure to epidophyllotoxins. | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Hematology]] | [[Category:Hematology]] | ||
[[Category:Types of cancer]] | [[Category:Types of cancer]] | ||
{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
Latest revision as of 15:04, 14 August 2015
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Acute monocytic leukemia Microchapters |
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Differentiating Acute monocytic leukemia from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Acute monocytic leukemia pathophysiology On the Web |
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American Roentgen Ray Society Images of Acute monocytic leukemia pathophysiology |
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Risk calculators and risk factors for Acute monocytic leukemia pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
Genetics
M5 is associated with characteristic chromosomal abnormalities, often involving 11q23 or t(9;11)affecting the MLL locus, however the MLL translocation is also found in other AML subtypes. MLL is believed to be prognostically unfavorable in AML-M5 compared to other genetic alterations involving MLL such as t(9;11) The t(8;16) translocation in MLL is associated with hemophagocytosis.
Immunology
Immunophenotypically, M5-AML variably express myeloid (CD13, CD33) and monocytic (CD11b, CD11c) markers. Cells may aberrantly express B cells marker CD20 and the NK marker CD56. Monoblasts may be positive for CD34.
Risk Factors
AML-M5 is thought to be associated with exposure to epidophyllotoxins.