Bithionol: Difference between revisions

	WikiDoc Resources for Bithionol
Articles
Most recent articles on Bithionol Most cited articles on Bithionol Review articles on Bithionol Articles on Bithionol in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Bithionol Images of Bithionol Photos of Bithionol Podcasts & MP3s on Bithionol Videos on Bithionol
Evidence Based Medicine
Cochrane Collaboration on Bithionol Bandolier on Bithionol TRIP on Bithionol
Clinical Trials
Ongoing Trials on Bithionol at Clinical Trials.gov Trial results on Bithionol Clinical Trials on Bithionol at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Bithionol NICE Guidance on Bithionol NHS PRODIGY Guidance FDA on Bithionol CDC on Bithionol
Books
Books on Bithionol
News
Bithionol in the news Be alerted to news on Bithionol News trends on Bithionol
Commentary
Blogs on Bithionol
Definitions
Definitions of Bithionol
Patient Resources / Community
Patient resources on Bithionol Discussion groups on Bithionol Patient Handouts on Bithionol Directions to Hospitals Treating Bithionol Risk calculators and risk factors for Bithionol
Healthcare Provider Resources
Symptoms of Bithionol Causes & Risk Factors for Bithionol Diagnostic studies for Bithionol Treatment of Bithionol
Continuing Medical Education (CME)
CME Programs on Bithionol
International
Bithionol en Espanol Bithionol en Francais
Business
Bithionol in the Marketplace Patents on Bithionol
Experimental / Informatics
List of terms related to Bithionol

Bithionol
Clinical data
Synonyms	2,4-dichloro- 6-(3,5-dichloro- 2-hydroxyphenyl)sulfanylphenol
ATC code	D10AB01 (WHO) P02BX01 (WHO) Template:ATCvet;
Identifiers
	IUPAC name 2,2'-sulfanediylbis(4,6-dichlorophenol);
CAS Number	97-18-7 ;
PubChem CID	2406;
IUPHAR/BPS	2338;
DrugBank	DB04813 ;
ChemSpider	2313 ;
UNII	AMT77LS62O;
ChEBI	CHEBI:3131 ;
ChEMBL	ChEMBL290106 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C12H6Cl4O2S
Molar mass	356.05 g/mol
3D model (JSmol)	Interactive image;
	SMILES Clc2cc(Cl)cc(Sc1cc(Cl)cc(Cl)c1O)c2O;
	InChI InChI=1S/C12H6Cl4O2S/c13-5-1-7(15)11(17)9(3-5)19-10-4-6(14)2-8(16)12(10)18/h1-4,17-18H ; Key:JFIOVJDNOJYLKP-UHFFFAOYSA-N ;
(what is this?) (verify)

← Older edit

VisualWikitext

Latest revision as of 18:11, 18 August 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Bithionol is an anthelmintic used to treat Anoplocephala perfoliata (tapeworms) in horses^[1] and Fasciola hepatica (liver flukes).

References

↑ Sanada Y, Senba H, Mochizuki R, Arakaki H, Gotoh T, Fukumoto S, Nagahata H (2009). "Evaluation of Marked Rise in Fecal Egg Output after Bithionol Administration to Horse and its Application as a Diagnostic Marker for Equine Anoplocephala perfoliata Infection" (pdf). Journal of Veterinary Medical Science. 71 (5): 617–620. doi:10.1292/jvms.71.617. PMID 19498288.

Template:Anthelmintics

[1] Sanada Y, Senba H, Mochizuki R, Arakaki H, Gotoh T, Fukumoto S, Nagahata H (2009). "Evaluation of Marked Rise in Fecal Egg Output after Bithionol Administration to Horse and its Application as a Diagnostic Marker for Equine Anoplocephala perfoliata Infection" (pdf). Journal of Veterinary Medical Science. 71 (5): 617–620. doi:10.1292/jvms.71.617. PMID 19498288.

[1]

@@ Line 1: / Line 1: @@
-__NOTOC__
+{{Drugbox
-{{CMG}}
+| Verifiedfields = changed
+| Watchedfields = changed
+| verifiedrevid = 459980346
+| IUPAC_name = 2,2'-sulfanediylbis(4,6-dichlorophenol)
+| image = Bithionol.png
+| image2 = Bithionol_molecule_ball.png
+| alt2 = Ball-and-stick model of the bithionol molecule
+| width2 = 240
-==Overview==
+<!--Clinical data-->
+| tradename =
+| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
+| pregnancy_US = <!-- A / B            / C / D / X -->
+| pregnancy_category =
+| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
+| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
+| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
+| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
+| legal_status =
+| routes_of_administration =
-Bithionol is an [[anthelmintic]] used to treat  "[[Anoplocephala perfoliata]]" (tapeworms) in horses<ref>[http://www.ncbi.nlm.nih.gov/pubmed/19498288], Sanada Y, Senba H, Mochizuki R, et al. Evaluation of marked rise in fecal egg output after bithionol administration to horse and its application as a diagnostic marker for equine Anoplocephala perfoliata infection. J. Vet. Med. Sci. May 2009;71(5):617-620.</ref> and ''[[Fasciola hepatica]]'' (liver flukes).
+<!--Pharmacokinetic data-->
+| bioavailability =
+| protein_bound =
+| metabolism =
+| elimination_half-life =
+| excretion =
-==Category==
+<!--Identifiers-->
+| CAS_number_Ref = {{cascite|changed|??}}
+| CAS_number = 97-18-7
+| ATC_prefix = D10
+| ATC_suffix = AB01
+| ATC_supplemental =  {{ATC|P02|BX01}} {{ATCvet|P52|AG07}}
+| PubChem = 2406
+| IUPHAR_ligand = 2338
+| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
+| DrugBank = DB04813
+| UNII_Ref = {{fdacite|correct|FDA}}
+| UNII = AMT77LS62O
+| ChEMBL_Ref = {{ebicite|correct|EBI}}
+| ChEMBL = 290106
+|  ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
+| ChemSpiderID = 2313
+|  ChEBI_Ref = {{ebicite|correct|EBI}}
+| ChEBI = 3131
+| smiles = Clc2cc(Cl)cc(Sc1cc(Cl)cc(Cl)c1O)c2O
+|  InChI = 1/C12H6Cl4O2S/c13-5-1-7(15)11(17)9(3-5)19-10-4-6(14)2-8(16)12(10)18/h1-4,17-18H
+|  InChIKey = JFIOVJDNOJYLKP-UHFFFAOYAO
+|  StdInChI_Ref = {{stdinchicite|correct|chemspider}}
+| StdInChI = 1S/C12H6Cl4O2S/c13-5-1-7(15)11(17)9(3-5)19-10-4-6(14)2-8(16)12(10)18/h1-4,17-18H
+|  StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
+| StdInChIKey = JFIOVJDNOJYLKP-UHFFFAOYSA-N
-Antiparasite
+<!--Chemical data-->
+| C=12 | H=6 | Cl=4 | O=2 | S=1
+| molecular_weight = 356.05 g/mol
+| synonyms = 2,4-dichloro- 6-(3,5-dichloro- 2-hydroxyphenyl)sulfanylphenol
+}}
+              __NOTOC__
+{{SI}}
+{{CMG}}
+==Overview==
+'''Bithionol''' is an [[anthelmintic]] used to treat ''[[Anoplocephala perfoliata]]'' (tapeworms) in horses<ref>{{ cite journal | author = Sanada Y, Senba H, Mochizuki R, Arakaki H, Gotoh T, Fukumoto S, Nagahata H | title = Evaluation of Marked Rise in Fecal Egg Output after Bithionol Administration to Horse and its Application as a Diagnostic Marker for Equine ''Anoplocephala perfoliata'' Infection | journal = Journal of Veterinary Medical Science | year = 2009 | volume = 71 | issue = 5 | pages = 617–620 | pmid = 19498288 | doi = 10.1292/jvms.71.617 | url = https://www.jstage.jst.go.jp/article/jvms/71/5/71_5_617/_pdf | format = pdf }}</ref> and ''[[Fasciola hepatica]]'' (liver flukes).
-==Brand Names==
+==References==
+{{reflist|2}}
-Bithionol is investigational in the U.S. The drug can be obtained from the Centers for Disease Control (CDC) Drug Service, CDC, Atlanta, Georgia 30333 (404-639-3670; evenings, weekends, or holidays: 404-639-2888).
-==Prescribing Information==
-====Dosage====
-======Adult Normal Dosage======
-'''Oral route'''
-) The recommended oral dose of bithionol for the treatment of Fascioliasis, and as alternative therapy in Paragonimiasis, is 30 to 50 milligrams/kilogram on alternate days for 10 to 15 doses.
-) Bithionol is usually given in 2 or 3 divided doses, and after meals to minimize gastrointestinal symptoms.
-======Pediatric Normal Dosage======
-'''Oral route'''
-) The recommended pediatric oral dose of bithionol for the treatment of Fascioliasis, and as alternative therapy in Paragonimiasis, is 30 to 50 milligrams/kilogram on alternate days for 10 to 15 doses.
-) Bithionol is usually given in 2 or 3 divided doses, and after meals to minimize gastrointestinal symptoms.
-====Pharmacokinetics====
-'''Onset'''
-a) Fascioliasis, 2 to 9 days.
-b) Resolution of fever has been reported 2 days after initiation of BITHIONOL therapy in fascioliasis, with eradication of ova in stools after 9 days.
-c) Paragonimiasis, 3 to 5 days. (Significant improvement of hemoptysis in paragonimiasis has been reported after the third dose of oral BITHIONOL. Eradication of Paragonimus westermani ova has occurred after the fifth dose.)
-'''Metabolism'''
-* Metabolism Sites and Kinetics: Not extensively studied in humans. Animal studies suggest that BITHIONOL is metabolized in the liver, with metabolites being excreted in bile and urine.
-====Contraindications====
-* Previous [[hypersensitivity]] to BITHIONOL
-====Precautions====
-* Renal insufficiency (potential accumulation)
-* Cardiovascular disease
-* Peptic ulcer disease
-* Asthma or other allergic-type disorders
-====Adverse Reactions====
-======Cardiovascular Effects======
-'''Cardiovascular finding'''
-* Extrasystoles, first-degree heart block, and hypertension have been reported rarely after bithionol administration [18].
-* Blood pressure irregularities, and errors in cardiac conduction are reported in association with the therapeutic use of bithionol.
-* [[Hypotension]]
-======Dermatologic Effects======
-* [[Photosensitivity]]
-* [[Rash]]
-* [[Urticaria]]
-======Endocrine/Metabolic Effects======
-* [[Hypoalbuminemia]]
+{{Anthelmintics}}
-* Increased body temperature
-======Gastrointestinal Effects======
-* [[Abdominal pain]]
-* [[Diarrhea]]
-* Loss of appetite
-* [[Nausea]]
-* [[Vomiting]]
-======Hematologic Effects======
-* [[Leukopenia]]
-======Hepatic Effects======
-* Hepatitis
-* Increased liver enzymes
-======Immunologic Effects======
-* [[Anaphylaxis]]
-* [[Jarisch-Herxheimer reaction]]
-======Neurologic Effects======
-* [[Dizziness]]
-* [[Headache]]
-======Respiratory Effects======
-* [[Cough]]
-* [[Respiratory distress]]
-* [[Tachypnea]]
-* [[Wheezing]]
-======Other======
-* [[Angioedema]]
-==Mechanism of Action==
-==References==
-{{Reflist|2}}
-[[Category:Antibiotics]]
+[[Category:Antiparasitic agents]]
-[[Category:Wikinfect]]
+[[Category:Organochlorides]]
+[[Category:Phenols]]
+[[Category:Thioethers]]
+[[Category:Drug]]

Bithionol: Difference between revisions

Latest revision as of 18:11, 18 August 2015

Overview

References

Navigation menu

Search