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#REDIRECT [[Captopril#Adverse Reactions]]
{{Captopril}}
{{CMG}}; {{AE}} {{AM}}


==Adverse Reactions==
[[Category: Cardiovascular Drugs]]
 
[[Category: Drug]]
Reported incidences are based on clinical trials involving approximately 7000 patients.
[[Category:ACE inhibitors]]
 
====Renal====
 
About one of 100 patients developed [[proteinuria]].
 
Each of the following has been reported in approximately 1 to 2 of 1000 patients and are of uncertain relationship to drug use: [[renal insufficiency]], [[renal failure]], [[nephrotic syndrome]], [[polyuria]], [[oliguria]], and [[urinary frequency]].
 
====Hematologic====
 
[[Neutropenia]]/[[agranulocytosis]] has occurred. Cases of [[anemia]], [[thrombocytopenia]], and [[pancytopenia]] have been reported.
 
====Dermatologic====
 
Rash, often with [[pruritus]], and sometimes with [[fever]], [[arthralgia]], and [[eosinophilia]], occurred in about 4 to 7 (depending on renal status and dose) of 100 patients, usually during the first four weeks of therapy. It is usually [[maculopapular]], and rarely urticarial. The rash is usually mild and disappears within a few days of dosage reduction, short-term treatment with an [[antihistamine]] agent, and/or discontinuing therapy; remission may occur even if captopril is continued. [[Pruritus]], without [[rash]], occurs in about 2 of 100 patients. Between 7 and 10 percent of patients with skin rash have shown an [[eosinophilia]] and/or positive [[ANA]] titers. A reversible associated [[pemphigoid]]-like lesion, and [[photosensitivity]], have also been reported.
 
[[Flushing]] or [[pallor]] has been reported in 2 to 5 of 1000 patients.
 
====Cardiovascular====
 
[[Hypotension]] may occur; for discussion of [[hypotension]] with captopril therapy.
 
[[Tachycardia]], [[chest pain]], and [[palpitations]] have each been observed in approximately 1 of 100 patients.
 
[[Angina pectoris]], [[myocardial infarction]], [[Raynaud's syndrome]], and [[congestive heart failure]] have each occurred in 2 to 3 of 1000 patients.
 
====Dysgeusia====
 
Approximately 2 to 4 (depending on renal status and dose) of 100 patients developed a diminution or loss of taste perception. Taste impairment is reversible and usually self-limited (2 to 3 months) even with continued drug administration. Weight loss may be associated with the loss of taste.
 
====Angioedema====
 
[[Angioedema]] involving the extremities, face, lips, mucous membranes, tongue, glottis or larynx has been reported in approximately one in 1000 patients. [[Angioedema]] involving the upper airways has caused fatal airway obstruction. (See WARNINGS, Head and Neck Angioedema , Intestinal Angioedema and PRECAUTIONS, Information for Patients.)
 
====Cough====
 
[[Cough]] has been reported in 0.5 to 2% of patients treated with captopril in clinical trials.
 
The following have been reported in about 0.5 to 2 percent of patients but did not appear at increased frequency compared to placebo or other treatments used in controlled trials: [[gastric irritation]], [[abdominal pain]], [[nausea]], [[vomiting]], [[diarrhea]], [[anorexia]], [[constipation]], [[aphthous ulcers]], [[peptic ulcer]], [[dizziness]], [[headache]], [[malaise]], [[fatigue]], [[insomnia]], [[dry mouth]], [[dyspnea]], [[alopecia]], [[paresthesias]].
 
Other clinical adverse effects reported since the drug was marketed are listed below by body system. In this setting, an incidence or causal relationship cannot be accurately determined.
 
====Body As A Whole====
 
[[Anaphylactoid reactions]] (see WARNINGS, Anaphylactoid and possible Related Reactions and PRECAUTIONS, Hemodialysis).
 
====General====
 
[[Asthenia]], [[gynecomastia]].
 
====Cardiovascular====
 
[[Cardiac arrest]], [[cerebrovascular accident]]/insufficiency, [[rhythm disturbances]], [[orthostatic hypotension]], [[syncope]].
 
====Dermatologic====
 
[[Bullous pemphigus]], [[erythema multiforme]] (including [[Stevens-Johnson syndrome]]), [[exfoliative dermatitis]].
 
====Gastrointestinal====
 
[[Pancreatitis]], [[glossitis]], [[dyspepsia]].
 
====Hematologic====
 
[[Anemia]], including [[aplastic]] and [[hemolytic]].
 
====Hepatobiliary====
 
[[Jaundice]], [[hepatitis]], including rare cases of [[necrosis]], [[cholestasis]].
 
====Metabolic====
 
Symptomatic [[hyponatremia]].
 
====Musculoskeletal====
 
[[Myalgia]], [[myasthenia]].
 
====Nervous/Psychiatric====
 
[[Ataxia]], [[confusion]], [[depression]], [[nervousness]], [[somnolence]].
 
====Respiratory====
 
[[Bronchospasm]], [[eosinophilic pneumonitis]], [[rhinitis]].
 
====Special Senses====
 
[[Blurred vision]].
 
====Urogenital====
 
[[Impotence]].
 
As with other ACE inhibitors, a syndrome has been reported which may include: [[fever]], [[myalgia]], [[arthralgia]], [[interstitial nephritis]], [[vasculitis]], [[rash]] or other dermatologic manifestations, [[eosinophilia]] and an elevated [[ESR]].
 
====Altered Laboratory Findings====
 
Serum Electrolytes
 
======Hyperkalemia======
Small increases in serum potassium, especially in patients with renal impairment.
 
======Hyponatremia======
 
Particularly in patients receiving a low sodium diet or concomitant [[diuretics]].
 
====BUN/Serum Creatinine====
 
Transient elevations of [[BUN]] or [[serum creatinine]] especially in volume or salt depleted patients or those with [[renovascular hypertension]] may occur. Rapid reduction of longstanding or markedly elevated blood pressure can result in decreases in the [[glomerular filtration rate]] and, in turn, lead to increases in BUN or serum creatinine.
 
====Hematologic====
 
A positive ANA has been reported.
 
====Liver Function Tests====
 
Elevations of [[liver transaminases]], [[alkaline phosphatase]], and [[serum bilirubin]] have occurred.<ref name="dailymed.nlm.nih.gov">{{Cite web  | last =  | first =  | title = CAPTOPRIL (CAPTOPRIL ) TABLET CAPTOPRIL TABLET [APOTEX CORP.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=2c0f1ee3-b2b7-a1bc-059a-d65bea6cd0ef | publisher =  | date =  | accessdate =}}</ref>
 
==References==
{{Reflist}}
 
{{FDA}}
 
[[Category:Cardiovascular Drugs]]
[[Category:Drugs]]

Latest revision as of 18:34, 18 August 2015