Flumedroxone: Difference between revisions

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Flumedroxone
Clinical data
Synonyms	(6S,10R,13S,17S)-17-acetyl-17-hydroxy-10,13-dimethyl-6-(trifluoromethyl)-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one; 17-Acetyloxy-6α-(trifluoromethyl)preg-4-ene-3,20-dione
ATC code	N02CB01 (WHO) ;
Identifiers
	IUPAC name (2R,8S,14S,15S)-14-acetyl-14-hydroxy-2,15-dimethyl-8-(trifluoromethyl)tetracyclo[8.7.0.02,7.011,15]heptadec-6-en-5-one;
CAS Number	987-18-8;
PubChem CID	71881;
ChemSpider	16736667;
UNII	K80185F39X;
ChEMBL	ChEMBL2104932;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C22H29F3O3
Molar mass	398.459 g/mol
3D model (JSmol)	Interactive image;
	SMILES CC(=O)[C@]1(CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2C[C@@H](C4=CC(=O)CC[C@]34C)C(F)(F)F)C)O;
	InChI InChI=1S/C22H29F3O3/c1-12(26)21(28)9-6-16-14-11-18(22(23,24)25)17-10-13(27)4-7-19(17,2)15(14)5-8-20(16,21)3/h10,14-16,18,28H,4-9,11H2,1-3H3/t14-,15+,16+,18+,19-,20+,21+/m1/s1; Key:CDZJOBWKHSYNMO-SCUQKFFVSA-N;
(verify)

VisualWikitext

Latest revision as of 21:03, 18 August 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Flumedroxone is a corticosteroid derivative used to treat migraines. In one study, the benefit was largely limited to women with headache associated with premenstrual syndrome.^[1]

References

↑ Bradley WG, Hudgson P, Foster JB, Newell DJ (August 1968). "Double-blind controlled trial of a micronized preparation of flumedroxone (Demigran) in prophylaxis of migraine". Br Med J. 3 (5617): 531–3. doi:10.1136/bmj.3.5617.531. PMC 1986487. PMID 4877801.

Template:Antimigraine preparations

Template:Analgesic-stub

[pmid4877801-1] Bradley WG, Hudgson P, Foster JB, Newell DJ (August 1968). "Double-blind controlled trial of a micronized preparation of flumedroxone (Demigran) in prophylaxis of migraine". Br Med J. 3 (5617): 531–3. doi:10.1136/bmj.3.5617.531. PMC 1986487. PMID 4877801.

[1]

@@ Line 1: / Line 1: @@
-__NOTOC__
+{{Drugbox
-{{Flumedroxone}}
+| verifiedrevid = 447816182
-{{CMG}}; {{AE}} {{PB}}
+| IUPAC_name = (2''R'',8''S'',14''S'',15''S'')-14-acetyl-14-hydroxy-2,15-dimethyl-8-(trifluoromethyl)tetracyclo[8.7.0.0<sup>2,7</sup>.0<sup>11,15</sup>]heptadec-6-en-5-one
+| image = Flumedroxone Wiki Str.png
-'''''For patient information about Flumedroxone, click [[Flumedroxone (patient information)|here]]'''''
+| alt = Skeletal formula of flumedroxone
-{{SB}}
+<!--Clinical data-->
+| tradename =
+| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
+| pregnancy_US = <!-- A / B            / C / D / X -->
+| pregnancy_category =
+| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
+| legal_CA = <!--             / Schedule I, II, III, IV, V, VI, VII, VIII -->
+| legal_UK = <!-- GSL         / P       / POM / CD / Class A, B, C -->
+| legal_US = <!-- OTC                   / Rx-only  / Schedule I, II, III, IV, V -->
+| legal_status =
+| routes_of_administration =
-==Overview==
+<!--Pharmacokinetic data-->
+| bioavailability =
+| protein_bound =
+| metabolism =
+| elimination_half-life =
+| excretion =
-==Category==
+<!--Identifiers-->
+| CAS_number = 987-18-8
+| ATC_prefix = N02
+| ATC_suffix = CB01
+| PubChem = 71881
+| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
+| DrugBank =
+| ChEMBL = 2104932
+| UNII_Ref = {{fdacite|correct|FDA}}
+| UNII = K80185F39X
+|  ChemSpiderID = 16736667
-==FDA Package Insert==
+<!--Chemical data-->
+| C=22 | H=29 | F=3 | O=3
+| molecular_weight = 398.459 g/mol
+|  smiles = CC(=O)[C@]1(CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2C[C@@H](C4=CC(=O)CC[C@]34C)C(F)(F)F)C)O
+|  InChI = 1/C22H29F3O3/c1-12(26)21(28)9-6-16-14-11-18(22(23,24)25)17-10-13(27)4-7-19(17,2)15(14)5-8-20(16,21)3/h10,14-16,18,28H,4-9,11H2,1-3H3/t14-,15+,16+,18+,19-,20+,21+/m1/s1
+|  InChIKey = CDZJOBWKHSYNMO-SCUQKFFVBJ
+|  StdInChI = 1S/C22H29F3O3/c1-12(26)21(28)9-6-16-14-11-18(22(23,24)25)17-10-13(27)4-7-19(17,2)15(14)5-8-20(16,21)3/h10,14-16,18,28H,4-9,11H2,1-3H3/t14-,15+,16+,18+,19-,20+,21+/m1/s1
+|  StdInChIKey = CDZJOBWKHSYNMO-SCUQKFFVSA-N
-'''| [[Flumedroxone indications and usage|Indications and Usage]]'''
+| synonyms = <small>(6''S'',10''R'',13''S'',17''S'')-17-acetyl-17-hydroxy-10,13-dimethyl-6-(trifluoromethyl)-2,6,7,8,9,11,12,14,15,16-decahydro-1''H''-cyclopenta[''a'']phenanthren-3-one<br>17-Acetyloxy-6α-(trifluoromethyl)preg-4-ene-3,20-dione</small>
-'''| [[Flumedroxone dosage and administration|Dosage and Administration]]'''
+}}
-'''| [[Flumedroxone dosage forms and strengths|Dosage Forms and Strengths]]'''
+__NOTOC__
-'''| [[Flumedroxone contraindications|Contraindications]]'''
+{{SI}}
-'''| [[Flumedroxone warnings and precautions|Warnings and Precautions]]'''
+{{CMG}}
-'''| [[Flumedroxone adverse reactions|Adverse Reactions]]'''
+== Overview ==
-'''| [[Flumedroxone drug interactions|Drug Interactions]]'''
-'''| [[Flumedroxone use in specific populations|Use in Specific Populations]]'''
-'''| [[Flumedroxone overdosage|Overdosage]]'''
-'''| [[Flumedroxone description|Description]]'''
-'''| [[Flumedroxone clinical pharmacology|Clinical Pharmacology]]'''
-'''| [[Flumedroxone nonclinical toxicology|Nonclinical Toxicology]]'''
-'''| [[Flumedroxone clinical studies|Clinical Studies]]'''
-'''| [[Flumedroxone how supplied storage and handling|How Supplied/Storage and Handling]]'''
-'''| [[Flumedroxone patient counseling information|Patient Counseling Information]]'''
-'''| [[Flumedroxone labels and packages|Labels and Packages]]'''
-==Mechanism of Action==
+'''Flumedroxone''' is a [[corticosteroid]] derivative used to treat [[migraine]]s. In one study, the benefit was largely limited to women with headache associated with [[premenstrual syndrome]].<ref name="pmid4877801">{{cite journal |author=Bradley WG, Hudgson P, Foster JB, Newell DJ |title=Double-blind controlled trial of a micronized preparation of flumedroxone (Demigran) in prophylaxis of migraine |journal=Br Med J |volume=3 |issue=5617 |pages=531–3 |date=August 1968 |pmid=4877801 |pmc=1986487 |doi= 10.1136/bmj.3.5617.531|url=}}</ref>
 ==References==
+{{reflist|2}}
+{{Antimigraine preparations}}
+[[Category:drug]]
+[[Category:Steroids]]
+[[Category:Organofluorides]]
-{{Reflist|2}}
-[[Category:Cardiovascular Drugs]]
+{{analgesic-stub}}
-[[Category:Drugs]]

Flumedroxone: Difference between revisions

Latest revision as of 21:03, 18 August 2015

Overview

References

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