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|indicationType=treatment
|indicationType=treatment
|indication=discoloration of skin, [[hyperpigmentation]] of skin
|indication=discoloration of skin, [[hyperpigmentation]] of skin
|adverseReactions=burning sensation, [[contact dermatitis]], localized [[erythema]]
|adverseReactions=burning sensation, [[contact dermatitis]], [[erythema|localized erythema]]
|blackBoxWarningTitle=Warning Title
|blackBoxWarningTitle=Warning Title
|blackBoxWarningBody=<i><span style="color:#FF0000;">Condition Name:</span></i> (Content)
|blackBoxWarningBody=<i><span style="color:#FF0000;">Condition Name:</span></i> (Content)
|fdaLIADAdult===Indications==
|fdaLIADAdult===Indications==
* Skin Lightening
* Skin Lightening
To gradually lighten [[hyperpigmentation]] of the skin such as age spots, liver spots, freckles or hyperpigmentation that can occur as a result of pregnancy or the use of oral contraceptives.
* To gradually lighten [[hyperpigmentation]] of the skin such as age spots, [[liver spots]], [[freckles]] or [[hyperpigmentation]] that can occur as a result of pregnancy or the use of oral contraceptives.


==Dosing==
==Dosing==
* Use fingertips to apply a thin layer to affected areas. Use both morning and night or as directed by a physician. Gradual lightening of the discolored area can be expected in most cases.
* Use fingertips to apply a thin layer to affected areas. Use both morning and night or as directed by a physician. Gradual lightening of the discolored area can be expected in most cases.
|offLabelAdultGuideSupport===Indications and Dosage==
|offLabelAdultGuideSupport===Indications and Dosage==
* Discoloration of skin: emulsion, apply TOPICALLY twice daily to affected area(s) or as directed by physician for no longer than 2 months.
* Discoloration of skin: emulsion, apply topically twice daily to affected area(s) or as directed by physician for no longer than 2 months.


* Hyperpigmentation of skin: cream and gel, with or without sunscreens, apply TOPICALLY twice daily to the affected area(s) or as directed by physician for no longer than 2 months; rub in well.
* Hyperpigmentation of skin: cream and gel, with or without sunscreens, apply topically twice daily to the affected area(s) or as directed by physician for no longer than 2 months; rub in well.


* Hyperpigmentation of skin: cream with sunblock, apply TOPICALLY twice daily to the affected area(s) or as directed by physician for no longer than 2 months; do not rub in.
* Hyperpigmentation of skin: cream with sunblock, apply topically twice daily to the affected area(s) or as directed by physician for no longer than 2 months; do not rub in.
|offLabelAdultNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of Hydroquinone in adult patients.
|offLabelAdultNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of Hydroquinone in adult patients.
|offLabelPedGuideSupport===Indications and Dosage==
|offLabelPedGuideSupport===Indications and Dosage==
* Safety and efficacy not established in children less than 12 years of age; not recommended for use except under physician supervision.
* Safety and efficacy not established in children less than 12 years of age; not recommended for use except under physician supervision.


* Discoloration of skin: 12 years and older; emulsion, apply TOPICALLY twice daily to affected area(s) or as directed by physician for no longer than 2 months.
* Discoloration of skin: 12 years and older; emulsion, apply topically twice daily to affected area(s) or as directed by physician for no longer than 2 months.


* Hyperpigmentation of skin: 12 years and older; cream and gel, with or without sunscreens, apply TOPICALLY twice daily to the affected area(s) or as directed by physician for no longer than 2 months; rub in well.
* Hyperpigmentation of skin: 12 years and older; cream and gel, with or without sunscreens, apply topically twice daily to the affected area(s) or as directed by physician for no longer than 2 months; rub in well.


* Hyperpigmentation of skin: 12 years and older; cream with sunblock, apply TOPICALLY twice daily to the affected area(s) or as directed by physician for no longer than 2 months; do not rub in.
* Hyperpigmentation of skin: 12 years and older; cream with sunblock, apply topically twice daily to the affected area(s) or as directed by physician for no longer than 2 months; do not rub in.
|offLabelPedNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of Hydroquinone in pediatric patients.
|offLabelPedNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of Hydroquinone in pediatric patients.
|contraindications=* Hypersensitivity to hydroquinone or any component of hydroquinone products.
|contraindications=* Hypersensitivity to hydroquinone or any component of hydroquinone products.
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|warnings=There is limited information regarding <i>Warnings</i> of Hydroquinone in  patients.
|warnings=There is limited information regarding <i>Warnings</i> of Hydroquinone in  patients.
|postmarketing=Dermatologic: Burning sensation, [[contact dermatitis]], localized [[erythema]]
|postmarketing=Dermatologic: Burning sensation, [[contact dermatitis]], localized [[erythema]]
|drugInteractions=There is limited information regarding <i>Drug Interactions</i> of Hydroquinone in  patients.
|othersTitle=Others
|othersTitle=Others
|administration='''Topical'''
|administration='''Topical'''
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   }}
   }}
}}
}}
|mechAction=* Hydroquinone inhibits the enzymatic oxidation of tyrosine to 3-(3,4-dihydroxyphenyl) alanine (dopa) and suppresses metabolic processes of melanocytes, thus producing depigmentation of the skin which is reversible
|mechAction=* Hydroquinone acts  by inhibiting the breakdown of tyrosine to 3-(3,4-dihydroxyphenyl) alanine (dopa) and thus suppresseing metabolic processes of melanocytes, to produce depigmentation of the skin which is reversible
|storage=* Store at room temperature (15-30°C / 59-86°F).
|storage=* Store at room temperature (15-30°C / 59-86°F).
* Close cap securely after each use.
* Close cap securely after each use.
Line 125: Line 126:
|fileName=Active 4.jpg
|fileName=Active 4.jpg
}}
}}
[[Category:Hydroquinones]]
[[Category:Drug]]

Latest revision as of 16:28, 20 August 2015

Hydroquinone
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2]

Disclaimer

WikiDoc MAKES NO GUARANTEE OF VALIDITY. WikiDoc is not a professional health care provider, nor is it a suitable replacement for a licensed healthcare provider. WikiDoc is intended to be an educational tool, not a tool for any form of healthcare delivery. The educational content on WikiDoc drug pages is based upon the FDA package insert, National Library of Medicine content and practice guidelines / consensus statements. WikiDoc does not promote the administration of any medication or device that is not consistent with its labeling. Please read our full disclaimer here.

Overview

Hydroquinone is a dermatological agent that is FDA approved for the treatment of discoloration of skin, hyperpigmentation of skin. Common adverse reactions include burning sensation, contact dermatitis, localized erythema.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Indications

Dosing

  • Use fingertips to apply a thin layer to affected areas. Use both morning and night or as directed by a physician. Gradual lightening of the discolored area can be expected in most cases.

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

Indications and Dosage

  • Discoloration of skin: emulsion, apply topically twice daily to affected area(s) or as directed by physician for no longer than 2 months.
  • Hyperpigmentation of skin: cream and gel, with or without sunscreens, apply topically twice daily to the affected area(s) or as directed by physician for no longer than 2 months; rub in well.
  • Hyperpigmentation of skin: cream with sunblock, apply topically twice daily to the affected area(s) or as directed by physician for no longer than 2 months; do not rub in.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Hydroquinone in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

There is limited information regarding Hydroquinone FDA-Labeled Indications and Dosage (Pediatric) in the drug label.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

Indications and Dosage

  • Safety and efficacy not established in children less than 12 years of age; not recommended for use except under physician supervision.
  • Discoloration of skin: 12 years and older; emulsion, apply topically twice daily to affected area(s) or as directed by physician for no longer than 2 months.
  • Hyperpigmentation of skin: 12 years and older; cream and gel, with or without sunscreens, apply topically twice daily to the affected area(s) or as directed by physician for no longer than 2 months; rub in well.
  • Hyperpigmentation of skin: 12 years and older; cream with sunblock, apply topically twice daily to the affected area(s) or as directed by physician for no longer than 2 months; do not rub in.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Hydroquinone in pediatric patients.

Contraindications

  • Hypersensitivity to hydroquinone or any component of hydroquinone products.
  • Pregnancy, safety not established.
  • Children 12 years of age and under; safety not established.

Warnings

There is limited information regarding Warnings of Hydroquinone in patients.

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Hydroquinone Clinical Trials Experience in the drug label.

Postmarketing Experience

Dermatologic: Burning sensation, contact dermatitis, localized erythema

Drug Interactions

There is limited information regarding Drug Interactions of Hydroquinone in patients.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA): There is no FDA guidance on usage of Hydroquinone in women who are pregnant.
Pregnancy Category (AUS): There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Hydroquinone in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Hydroquinone during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Hydroquinone in women who are nursing.

Pediatric Use

There is no FDA guidance on the use of Hydroquinone in pediatric settings.

Geriatic Use

There is no FDA guidance on the use of Hydroquinone in geriatric settings.

Gender

There is no FDA guidance on the use of Hydroquinone with respect to specific gender populations.

Race

There is no FDA guidance on the use of Hydroquinone with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Hydroquinone in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Hydroquinone in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Hydroquinone in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Hydroquinone in patients who are immunocompromised.

Others

Administration and Monitoring

Administration

Topical

  • Avoid exposure of treated areas to sunlight.
  • Avoid contact with eyes.

Monitoring

  • Repigmentation

IV Compatibility

There is limited information regarding IV Compatibility of Hydroquinone in patients.

Overdosage

There is limited information regarding Overdose of Hydroquinone in patients.

Pharmacology

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Template:Chembox header2 | Hydroquinone
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value).
KEGG
UNII
Properties
C6H6O2
Molar mass 110.11 g·mol−1
Hazards
Related compounds
Template:Chembox header2 | Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

Mechanism of Action

  • Hydroquinone acts by inhibiting the breakdown of tyrosine to 3-(3,4-dihydroxyphenyl) alanine (dopa) and thus suppresseing metabolic processes of melanocytes, to produce depigmentation of the skin which is reversible

Structure

There is limited information regarding Hydroquinone Structure in the drug label.

Pharmacodynamics

There is limited information regarding Hydroquinone Pharmacodynamics in the drug label.

Pharmacokinetics

There is limited information regarding Hydroquinone Pharmacokinetics in the drug label.

Nonclinical Toxicology

There is limited information regarding Hydroquinone Nonclinical Toxicology in the drug label.

Clinical Studies

There is limited information regarding Hydroquinone Clinical Studies in the drug label.

How Supplied

There is limited information regarding Hydroquinone How Supplied in the drug label.

Storage

  • Store at room temperature (15-30°C / 59-86°F).
  • Close cap securely after each use.

Images

Drug Images

{{#ask: Page Name::Hydroquinone |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

{{#ask: Label Page::Hydroquinone |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Hydroquinone Patient Counseling Information in the drug label.

Precautions with Alcohol

Alcohol-Hydroquinone interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

ACTIVE 4

Look-Alike Drug Names

There is limited information regarding Hydroquinone Look-Alike Drug Names in the drug label.

Drug Shortage Status

Drug Shortage

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. ↑ http://assets.openstudy.com/updates/attachments/4f0d5cb6e4b084a815fccd72-chmvijay-1326448458607-dipolemoment.pdf

{{#subobject: 

 |Label Page=Hydroquinone
 |Label Name=Hydroquinone ingredients and appearance.png

}}

{{#subobject: 

 |Label Page=Hydroquinone
 |Label Name=Active 4.jpg

}}

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