Mizolastine: Difference between revisions

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List of terms related to Mizolastine

Mizolastine
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral
ATC code	R06AX25 (WHO) ;
Legal status
Legal status	POM;
Identifiers
	IUPAC name 2-[{1-[1-(4-fluorobenzyl)-1H-benzimidazol-2-yl]piperidin-4-yl}(methyl)amino]pyrimidin-4(1H)-one;
CAS Number	108612-45-9 ;
PubChem CID	65906;
ChemSpider	59315 ;
UNII	244O1F90NA;
KEGG	D01117 ;
ChEMBL	ChEMBL94454 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C24H25FN6O
Molar mass	432.493 g/mol
3D model (JSmol)	Interactive image;
	SMILES CN(C1CCN(CC1)C2=NC3=CC=CC=C3N2CC4=CC=C(C=C4)F)C5=NC=CC(=O)N5;
	InChI InChI=1S/C24H25FN6O/c1-29(23-26-13-10-22(32)28-23)19-11-14-30(15-12-19)24-27-20-4-2-3-5-21(20)31(24)16-17-6-8-18(25)9-7-17/h2-10,13,19H,11-12,14-16H2,1H3,(H,26,28,32) ; Key:PVLJETXTTWAYEW-UHFFFAOYSA-N ;
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VisualWikitext

Latest revision as of 16:44, 20 August 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Mizolastine (Mizollen) is a once daily, non-sedating antihistamine. It blocks H₁ receptors and is commonly fast-acting. It does not prevent the actual release of histamine from mast cells, just prevents it binding to receptors. Side effects can include dry mouth and throat.^[1]

References

↑ "MIZOLASTINE: British National Formulary". Retrieved 2010-02-01.

[1] "MIZOLASTINE: British National Formulary". Retrieved 2010-02-01.

[1]

@@ Line 1: / Line 1: @@
 {{Drugbox
-| IUPAC_name        = 2-[ [1-[1-[(4-fluorophenyl)methyl]benzimidazol-2-yl]piperidin-4-yl]-methylamino]-3H-pyrimidin-4-one
+| Verifiedfields = changed
-| image             =
+| Watchedfields = changed
-| CAS_number        =
+| verifiedrevid = 449584902
-| ATC_prefix        = R06
+| IUPAC_name = 2-[{1-[1-(4-fluorobenzyl)-1''H''-benzimidazol-2-yl]piperidin-4-yl}(methyl)amino]pyrimidin-4(1''H'')-one
-| ATC_suffix        = AX25
+| image = mizolastine.png
-| PubChem           = 65906
-| DrugBank          =
+<!--Clinical data-->
-| C=24|H=25|F=1|N=6|O=1
+| tradename =
-| molecular_weight  = 432.493 g/mol
+| Drugs.com = {{drugs.com|international|mizolastine}}
-| bioavailability   =
+| pregnancy_category =
-| protein_bound     =
+| legal_status = POM
-| metabolism        =
+| routes_of_administration = Oral
-| elimination_half-life =
-| excretion         =
+<!--Pharmacokinetic data-->
-| pregnancy_AU      =  <!-- A / B1 / B2 / B3 / C / D / X -->
+| bioavailability =
-| pregnancy_US      =  <!-- A / B            / C / D / X -->
+| protein_bound =
-| pregnancy_category=
+| metabolism =
-| legal_AU          =  <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
+| elimination_half-life =
-| legal_CA          =  <!--             / Schedule I, II, III, IV, V, VI, VII, VIII -->
+| excretion =
-| legal_UK          =  <!-- GSL         / P       / POM / CD / Class A, B, C -->
-| legal_US          =  <!-- OTC                   / Rx-only  / Schedule I, II, III, IV, V -->
+<!--Identifiers-->
-| legal_status      =
+| CAS_number_Ref = {{cascite|correct|??}}
-| routes_of_administration =
+| CAS_number = 108612-45-9
+| ATC_prefix = R06
+| ATC_suffix = AX25
+| PubChem = 65906
+| UNII_Ref = {{fdacite|correct|FDA}}
+| UNII = 244O1F90NA
+| KEGG_Ref = {{keggcite|correct|kegg}}
+| KEGG = D01117
+| ChEMBL_Ref = {{ebicite|changed|EBI}}
+| ChEMBL = 94454
+| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
+| ChemSpiderID      = 59315
+<!--Chemical data-->
+| C=24 | H=25 | F=1 | N=6 | O=1
+| molecular_weight = 432.493 g/mol
+| smiles            = CN(C1CCN(CC1)C2=NC3=CC=CC=C3N2CC4=CC=C(C=C4)F)C5=NC=CC(=O)N5
+| InChI             = 1/C24H25FN6O/c1-29(23-26-13-10-22(32)28-23)19-11-14-30(15-12-19)24-27-20-4-2-3-5-21(20)31(24)16-17-6-8-18(25)9-7-17/h2-10,13,19H,11-12,14-16H2,1H3,(H,26,28,32)
+| InChIKey          = PVLJETXTTWAYEW-UHFFFAOYAR
+| StdInChI_Ref = {{stdinchicite|changed|chemspider}}
+| StdInChI          = 1S/C24H25FN6O/c1-29(23-26-13-10-22(32)28-23)19-11-14-30(15-12-19)24-27-20-4-2-3-5-21(20)31(24)16-17-6-8-18(25)9-7-17/h2-10,13,19H,11-12,14-16H2,1H3,(H,26,28,32)
+| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}
+| StdInChIKey       = PVLJETXTTWAYEW-UHFFFAOYSA-N
 }}
+              __NOTOC__
 {{SI}}
+{{CMG}}
+==Overview==
-{{EH}}
+'''Mizolastine''' ('''Mizollen''') is a once daily, non-sedating [[antihistamine]]. It blocks [[H1 receptor|H<sub>1</sub> receptor]]s and is commonly fast-acting. It does not prevent the actual release of histamine from mast cells, just prevents it binding to receptors. Side effects can include dry mouth and throat.<ref>{{Cite web
-==Overview==
+| title = MIZOLASTINE: British National Formulary
-'''Mizolastine''' is an [[antihistamine]].
+| accessdate = 2010-02-01
+| url = http://bnf.org/bnf/bnf/58/68614.htm
+}}</ref>
+== References ==
+{{Reflist|2}}
 {{Antihistamines}}
-{{SIB}}
 [[Category:Benzimidazoles]]
 [[Category:Piperidines]]
+[[Category:H1 receptor antagonists]]
-{{WH}}
+[[Category:Organofluorides]]
-{{WikiDoc Sources}}
+[[Category:Drug]]

v t e Antihistamines (R06)
Aminoalkyl ethers	Bromazine/Bromodiphenhydramine • Carbinoxamine • Clemastine • Chlorphenoxamine • Diphenylpyraline • Diphenhydramine • Doxylamine • Orphenadrine • Phenyltoloxamine
Substituted alkylamines	Brompheniramine • Chlorphenamine • Dexbrompheniramine • Dexchlorpheniramine • Dimetindene • Pheniramine • Talastine
Substituted ethylenediamines	Chloropyramine • Histapyrrodine • Mepyramine • Methapyrilene • Tripelennamine (Pyribenzamine)
Phenothiazine derivatives	Alimemazine • Hydroxyethylpromethazine • Isothipendyl • Mequitazine • Methdilazine • Oxomemazine • Promethazine
Piperazine derivatives	Buclizine • Cetirizine • Chlorcyclizine • Cinnarizine • Cyclizine • Hydroxyzine • Levocetirizine • Meclizine • Niaprazine • Oxatomide
Others for systemic use	Antazoline • Azatadine • Bamipine • Cyproheptadine • Deptropine • Dimebon • Ebastine • Epinastine • Ketotifen • Mebhydrolin • Mizolastine • Phenindamine • Pimethixene • Pyrrobutamine • Rupatadine • Triprolidine • selective (Acrivastine • Astemizole • Azelastine • Desloratadine • Fexofenadine • Loratadine • Terfenadine)
For topical use	Bamipine • Chloropyramine • Chlorphenoxamine • Clemastine • Dimetindene • Diphenhydramine • Isothipendyl • Mepyramine • Promethazine • Thenalidine
Antiallergic agents excluding corticosteroids	Antazoline • Azelastine
Other antiallergics	Emedastine • Epinastine • Ketotifen • Montelukast • Olopatadine

Clinical data

AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
ATC code	R06AX25 (WHO)
Legal status
Legal status	POM
Identifiers
IUPAC name 2-[{1-[1-(4-fluorobenzyl)-1H-benzimidazol-2-yl]piperidin-4-yl}(methyl)amino]pyrimidin-4(1H)-one
CAS Number	108612-45-9^Y
PubChem CID	65906
ChemSpider	59315^N
UNII	244O1F90NA
KEGG	D01117^Y
ChEMBL	ChEMBL94454^N
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₂₄H₂₅FN₆O
Molar mass	432.493 g/mol
3D model (JSmol)	Interactive image
SMILES CN(C1CCN(CC1)C2=NC3=CC=CC=C3N2CC4=CC=C(C=C4)F)C5=NC=CC(=O)N5
InChI InChI=1S/C24H25FN6O/c1-29(23-26-13-10-22(32)28-23)19-11-14-30(15-12-19)24-27-20-4-2-3-5-21(20)31(24)16-17-6-8-18(25)9-7-17/h2-10,13,19H,11-12,14-16H2,1H3,(H,26,28,32)^N Key:PVLJETXTTWAYEW-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

Mizolastine: Difference between revisions

Latest revision as of 16:44, 20 August 2015

Overview

References

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