Niperotidine: Difference between revisions
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==Overview== | ==Overview== | ||
'''Niperotidine''' is a [[histamine antagonist]] selective for the [[Histamine H2 receptor|H<sub>2</sub>]] subtype. It was trialled as a treatment for excessive gastric acidity,<ref>Palasciano G, Maggi V, Portincasa P. The effect of the H2-antagonist niperotidine on intragastric acidity in healthy subjects undergoing 24-hour pH-monitoring. ''Italian Journal of Gastroenterology''. 1990 Oct;22(5):291-4. PMID 1983712</ref> but withdrawn after human trials showed [[hepatotoxicity|liver damage]].<ref>Gasbarrini G, Gentiloni N, Febbraro S, Gasbarrini A, Di Campli C, Cesana M, Miglio F, Miglioli M, Ghinelli F, D'Ambrosi A, Amoroso P, Pacini F, Salvadori G. Acute liver injury related to the use of niperotidine. ''Journal of Hepatology''. 1997 Sep;27(3):583-6. PMID 9314138</ref> | '''Niperotidine''' is a [[histamine antagonist]] selective for the [[Histamine H2 receptor|H<sub>2</sub>]] subtype. It was trialled as a treatment for excessive gastric acidity,<ref>Palasciano G, Maggi V, Portincasa P. The effect of the H2-antagonist niperotidine on intragastric acidity in healthy subjects undergoing 24-hour pH-monitoring. ''Italian Journal of Gastroenterology''. 1990 Oct;22(5):291-4. PMID 1983712</ref> but withdrawn after human trials showed [[hepatotoxicity|liver damage]].<ref>Gasbarrini G, Gentiloni N, Febbraro S, Gasbarrini A, Di Campli C, Cesana M, Miglio F, Miglioli M, Ghinelli F, D'Ambrosi A, Amoroso P, Pacini F, Salvadori G. Acute liver injury related to the use of niperotidine. ''Journal of Hepatology''. 1997 Sep;27(3):583-6. PMID 9314138</ref> | ||
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[[Category:H2 receptor antagonists]] | [[Category:H2 receptor antagonists]] | ||
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[[Category:Thioethers]] | [[Category:Thioethers]] | ||
[[Category:Furans]] | [[Category:Furans]] | ||
[[Category:Amines]] | [[Category:Amines]] | ||
Latest revision as of 16:48, 20 August 2015
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| IUPAC name
(Z)-N-(1,3-benzodioxol-5-ylmethyl)-N'-{2[({5-[(dimethylamino)methyl]-2-furyl}methyl)thio]ethyl}-2-nitroethylene-1,1-diamine
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| ECHA InfoCard | Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). |
| KEGG | |
| MeSH | C073716 |
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| C20H26N4O5S | |
| Molar mass | 434.50924 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Niperotidine is a histamine antagonist selective for the H2 subtype. It was trialled as a treatment for excessive gastric acidity,[1] but withdrawn after human trials showed liver damage.[2]
References
- ↑ Palasciano G, Maggi V, Portincasa P. The effect of the H2-antagonist niperotidine on intragastric acidity in healthy subjects undergoing 24-hour pH-monitoring. Italian Journal of Gastroenterology. 1990 Oct;22(5):291-4. PMID 1983712
- ↑ Gasbarrini G, Gentiloni N, Febbraro S, Gasbarrini A, Di Campli C, Cesana M, Miglio F, Miglioli M, Ghinelli F, D'Ambrosi A, Amoroso P, Pacini F, Salvadori G. Acute liver injury related to the use of niperotidine. Journal of Hepatology. 1997 Sep;27(3):583-6. PMID 9314138
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