Oxetorone: Difference between revisions

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__NOTOC__
{{XXXXX}}
{{CMG}}; {{AE}} {{PB}}
'''''For patient information about Oxetorone, click [[Oxetorone (patient information)|here]].'''''
{{SB}} <sup>®</sup>,
==Overview==
{{Drugbox
{{Drugbox
| verifiedrevid = 444750715
| verifiedrevid = 444750715
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| width = 180
| width = 180
| alt = Ball-and-stick model
| alt = Ball-and-stick model
| image2 = Oxetorone-3D-balls.png
| image2 = 360px-Oxetorone-3D-balls.png
| alt2 = Ball-and-stick model
| alt2 = Ball-and-stick model
<!--Clinical data-->
<!--Clinical data-->
| tradename =  
| tradename =
| Drugs.com = {{drugs.com|international|oxetorone}}
| Drugs.com = {{drugs.com|international|oxetorone}}
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B            / C / D / X -->
| pregnancy_US = <!-- A / B            / C / D / X -->
| pregnancy_category =  
| pregnancy_category =
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
| legal_status =  
| legal_status =
| routes_of_administration =  
| routes_of_administration =


<!--Pharmacokinetic data-->
<!--Pharmacokinetic data-->
| bioavailability =  
| bioavailability =
| protein_bound =  
| protein_bound =
| metabolism =  
| metabolism =
| elimination_half-life =  
| elimination_half-life =
| excretion =  
| excretion =


<!--Identifiers-->
<!--Identifiers-->
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| PubChem = 6436540
| PubChem = 6436540
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank =  
| DrugBank =
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = T3XOS33TIQ
| UNII = T3XOS33TIQ
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<!--Chemical data-->
<!--Chemical data-->
| chemical_formula =  
| chemical_formula =
| C=21 | H=21 | N=1 | O=2
| C=21 | H=21 | N=1 | O=2  
| molecular_weight = 319.40 g/mol
| molecular_weight = 319.40 g/mol
| smiles = CN(C)CCC=C1C2=CC=CC=C2OCC3=C1OC4=CC=CC=C34
| smiles = CN(C)CCC=C1C2=CC=CC=C2OCC3=C1OC4=CC=CC=C34
}}
}}
                    __NOTOC__
{{SI}}
{{CMG}}


'''Oxetorone''' is an [[antimigraine]] agent.<ref name="pmid11139754">{{cite journal |author=Massiou H |title=[Prophylactic treatments of migraine] |language=French |journal=Rev. Neurol. (Paris) |volume=156 Suppl 4 |issue= |pages=4S79–86 |year=2000 |pmid=11139754 |doi= |url=http://www.masson.fr/masson/79997}}</ref>
==Overview==
'''Oxetorone''' ([[International Nonproprietary Name|INN]]), as '''oxetorone fumarate''' ([[United States Adopted Name|USAN]]) (brand names '''Nocertone''', '''Oxedix'''), is a [[serotonin antagonist]], [[antihistamine]], and [[alpha blocker]] used as an [[antimigraine drug]].<ref name="GanellinTriggle1996">{{cite book|author1=C.R. Ganellin|author2=David J. Triggle|title=Dictionary of Pharmacological Agents|url=http://books.google.com/books?id=A0THacd46ZsC&pg=PA1493|date=21 November 1996|publisher=CRC Press|isbn=978-0-412-46630-4|pages=1493–}}</ref><ref name="Publishing2013">{{cite book|author=William Andrew Publishing|title=Pharmaceutical Manufacturing Encyclopedia, 3rd Edition|url=http://books.google.com/books?id=_J2ti4EkYpkC&pg=PA2935-IA131|date=22 October 2013|publisher=Elsevier|isbn=978-0-8155-1856-3|pages=2935–}}</ref><ref name="BoxtelSantoso2008">{{cite book|author1=C.J. van Boxtel|author2=B. Santoso|author3=I.R. Edwards|title=Drug Benefits and Risks: International Textbook of Clinical Pharmacology - Revised 2nd Edition|url=http://books.google.com/books?id=idbvAgAAQBAJ&pg=PA699|date=6 August 2008|publisher=IOS Press|isbn=978-1-60750-345-3|pages=699–}}</ref><ref name="pmid11139754">{{cite journal |author=Massiou H |title=[Prophylactic treatments of migraine] |language=French |journal=Rev. Neurol. (Paris) |volume=156 Suppl 4 |issue= |pages=4S79–86 |year=2000 |pmid=11139754 |doi= |url=http://www.masson.fr/masson/79997}}</ref>


Association with [[hyperprolactinemia]] has been described.<ref name="pmid8980859">{{cite journal |author=Pradalier A |title=Hyperprolactinaemia and depression induced by oxetorone |journal=Cephalalgia |volume=16 |issue=8 |pages=560–1 |date=December 1996 |pmid=8980859 |doi= 10.1046/j.1468-2982.1996.1608560.x|url=http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0333-1024&date=1996&volume=16&issue=8&spage=560}}</ref> <ref>{{Cite web  | last =  | first =  | title = Oxetorone - Wikipedia, the free encyclopedia | url = http://en.wikipedia.org/wiki/Oxetorone | publisher =  | date =  | accessdate =  }}</ref>
Association with [[hyperprolactinemia]] has been described.<ref name="pmid8980859">{{cite journal |author=Pradalier A |title=Hyperprolactinaemia and depression induced by oxetorone |journal=Cephalalgia |volume=16 |issue=8 |pages=560–1 |date=December 1996 |pmid=8980859 |doi= 10.1046/j.1468-2982.1996.1608560.x|url=http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0333-1024&date=1996&volume=16&issue=8&spage=560}}</ref>


==References==
==References==
{{Reflist|2}}


{{Reflist|2}}


{{Antimigraine preparations}}
{{Antimigraine preparations}}
[[Category:Drugs]]
 
 
[[Category:Alpha blockers]]
[[Category:Antimigraine drugs]]
[[Category:H1 receptor antagonists]]
[[Category:Heterocyclic compounds (3 rings)]]
[[Category:Drug]]

Latest revision as of 16:52, 20 August 2015

Oxetorone
Ball-and-stick model
Ball-and-stick model
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
CAS Number
PubChem CID
UNII
KEGG
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC21H21NO2
Molar mass319.40 g/mol
3D model (JSmol)
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Oxetorone (INN), as oxetorone fumarate (USAN) (brand names Nocertone, Oxedix), is a serotonin antagonist, antihistamine, and alpha blocker used as an antimigraine drug.[1][2][3][4]

Association with hyperprolactinemia has been described.[5]

References

  1. ↑ C.R. Ganellin; David J. Triggle (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. pp. 1493–. ISBN 978-0-412-46630-4.
  2. ↑ William Andrew Publishing (22 October 2013). Pharmaceutical Manufacturing Encyclopedia, 3rd Edition. Elsevier. pp. 2935–. ISBN 978-0-8155-1856-3.
  3. ↑ C.J. van Boxtel; B. Santoso; I.R. Edwards (6 August 2008). Drug Benefits and Risks: International Textbook of Clinical Pharmacology - Revised 2nd Edition. IOS Press. pp. 699–. ISBN 978-1-60750-345-3.
  4. ↑ Massiou H (2000). "[Prophylactic treatments of migraine]". Rev. Neurol. (Paris) (in French). 156 Suppl 4: 4S79–86. PMID 11139754.
  5. ↑ Pradalier A (December 1996). "Hyperprolactinaemia and depression induced by oxetorone". Cephalalgia. 16 (8): 560–1. doi:10.1046/j.1468-2982.1996.1608560.x. PMID 8980859.


Template:Antimigraine preparations

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