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| __NOTOC__
| | #REDIRECT [[Reteplase#Structure]] |
| {{Reteplase}}
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| {{CMG}}; {{AE}} {{AZ}}
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| ==Description==
| | [[Category: Cardiovascular Drugs]] |
| | | [[Category: Drug]] |
| Retavase® (Reteplase) is a non-glycosylated deletion mutein of tissue [[plasminogen activator]] (tPA), containing the kringle 2 and the protease domains of human tPA. Retavase® contains 355 of the 527 amino acids of native tPA (amino acids 1-3 and 176-527). Retavase® is produced by recombinant DNA technology in[[ E. coli]]. The protein is isolated as inactive inclusion bodies from [[E. coli]], converted into its active form by an in vitro folding process and purified by chromatographic separation. The molecular weight of Reteplase is 39,571 daltons.
| | [[Category: Anticoagulants]] |
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| Potency is expressed in units (U) using a reference standard which is specific for Retavase® and is not comparable with units used for other [[thrombolytic|thrombolytic agents]].
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| Retavase® is a sterile, white, lyophilized powder for intravenous bolus injection after reconstitution with Sterile Water for Injection, USP (without preservatives). Following reconstitution, the pH is 6.0 ± 0.3. Retavase® is supplied as a 10.4 unit vial to ensure sufficient drug for administration of each 10 unit injection. Each single-use vial contains<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = RETAVASE (RETEPLASE) KIT [EKR THERAPEUTICS, INC.] | url =http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=e9ae6656-977c-4105-8528-bee664aab27a | publisher = | date = | accessdate = }}</ref>:
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| :*Reteplase : 18.1 mg
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| :*Tranexamic Acid : 8.32 mg
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| :*Dipotassium Hydrogen Phosphate : 136.24 mg
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| :*Phosphoric Acid : 51.27 mg
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| :*Sucrose : 364.0 mg
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| :*Polysorbate 80 : 5.20 mg
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| ==References==
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| {{Reflist}}
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| {{FDA}}
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| [[Category:Cardiovascular Drugs]] | |
| [[Category:Drugs]] | |