Bone marrow disorders: Difference between revisions

Latest revision as of 23:33, 20 August 2015

For congenital bone marrow disorders, click here.
For acquired bone marrow disorders, click here.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Yazan Daaboul, M.D.; Rim Halaby, M.D. [2]; Serge Korjian M.D.

Overview

Bone marrow disorders are classified into congenital bone marrow disorders and acquired bone marrow disorders.

Definition of Terms

Bone marrow suppression: Reduced numbers of cells in the bone marrow
- Myelosuppression: Reduced number of myeloid lineage cells (RBC, neutrophils, basophils, eosinophils, monocytes, platelets, mastocytes)
- Immunosuppression or lymphosuppression: Reduced number of lymphoid lineage cells (T-cell, B-cell, NK cell)

Bone marrow proliferation: Increased numbers of cells in the bone marrow
- Myeloproliferation: Increased number of myeloid lineage cells (RBC, neutrophils, basophils, eosinophils, monocytes, platelets, mastocytes)
- Immunoproliferation or lymphoproliferation: Increased number of lymphoid lineage cells (T-cell, B-cell, NK cell)

Classification

Shown below is an algorithm depicting the different classes of bone marrow disorders.

Bone Marrow Disorders

Acquired disorders of the bone marrow

Congenital disorders of the bone marrow

Bone marrow suppression

Bone marrow proliferation

Mixed or unclassified

Bone marrow suppression

Bone marrow proliferation

References

@@ Line 1: / Line 1: @@
 __NOTOC__
-'''''For congenital bone marrow disorders click [[congenital bone marrow disorders|here]].'''''<br>
+'''''For congenital bone marrow disorders, click [[congenital bone marrow disorders|here]].'''''<br>
-'''''For acquired bone marrow disorders click [[acquired bone marrow disorders|here]].'''''
+'''''For acquired bone marrow disorders, click [[acquired bone marrow disorders|here]].'''''
-{{CMG}}; {{AE}} {{Rim}}; {{YD}}; {{SSK}}
+{{CMG}} {{AE}} {{YD}}; {{Rim}}; {{SSK}}
 ==Overview==
 Bone marrow disorders are classified into [[congenital bone marrow disorders]] and [[acquired bone marrow disorders]].
+==Definition of Terms==
+* '''Bone marrow suppression''': Reduced numbers of cells in the bone marrow
+** '''Myelosuppression''': Reduced number of [[myeloid]] lineage cells ([[RBC]], [[neutrophils]], [[basophils]], [[eosinophils]], [[monocyte]]s, [[platelets]], [[mastocytes]])
+** '''Immunosuppression or lymphosuppression''': Reduced number of [[lymphoid]] lineage cells ([[T-cell]], [[B-cell]], [[NK cell]])
+* '''Bone marrow proliferation''': Increased numbers of cells in the bone marrow
+** '''Myeloproliferation''': Increased number of [[myeloid]] lineage cells ([[RBC]], [[neutrophils]], [[basophils]], [[eosinophils]], [[monocyte]]s, [[platelets]], [[mastocytes]])
+** '''Immunoproliferation or lymphoproliferation''': Increased number of [[lymphoid]] lineage cells ([[T-cell]], [[B-cell]], [[NK cell]])
 ==Classification==
@@ Line 13: / Line 22: @@
 {{Family tree |boxstyle= padding: 0; background: #FFA07A;| | | | | | | | | | | | | | A01 | | | | | | | | | | A01= '''Bone Marrow Disorders'''}}
 {{Family tree | | | | | | | |,|-|-|-|-|-|-|^|-|-|-|-|-|-|.| | | | }}
-{{Family tree |boxstyle= padding: 0; background: #66CDAA; | | | | | | | B01 | | | | | | | | | | | | B02 | | | B01= <div style="width: 10em">'''[[Congenital disorders of the bone marrow]]''' </div>| B02= <div style="width: 10em">'''[[Acquired disorders of the bone marrow]]''' </div>}}
+{{Family tree |boxstyle= padding: 0; background: #66CDAA; | | | | | | | B01 | | | | | | | | | | | | B02 | | | B01= <div style="width: 10em">'''[[Acquired disorders of the bone marrow]]''' </div>|B02= <div style="width: 10em">'''[[Congenital disorders of the bone marrow]]''' </div>}}
 {{Family tree | | | |,|-|-|-|^|-|-|-|v|-|-|-|.| | | |,|-|^|-|.| | }}
-{{Family tree |boxstyle= padding: 0; background: #DCDCDC; | | | C01 | | | | | | C02 | | C03 | | C04 | | C05 | C01= <div style="width: 7em">Bone marrow suppression </div>| C02= <div style="width: 7em">Bone marrow proliferation</div>| C03= <div style="width: 7em">Mixed or unclassified</div>| C04= <div style="width: 7em">Inherited bone marrow failure syndromes</div>| C05= <div style="width: 7em">Inherited bone marrow proliferative syndromes</div>}}
+{{Family tree |boxstyle= padding: 0; background: #DCDCDC; | | | C01 | | | | | | C02 | | C03 | | C04 | | C05 | C01= <div style="width: 7em">[[Acquired disorders of the bone marrow#Bone Marrow Suppression|Bone marrow suppression]] </div>| C02= <div style="width: 7em">[[Acquired disorders of the bone marrow#Bone Marrow Proliferation|Bone marrow proliferation]]</div>| C03= <div style="width: 7em">[[Acquired disorders of the bone marrow#Mixed or Unclassified Disorders|Mixed or unclassified]]</div>| C04= <div style="width: 7em">[[Congenital disorders of the bone marrow#Inherited Bone Marrow Failure Syndromes|Bone marrow suppression]]</div>| C05= <div style="width: 7em">[[Congenital disorders of the bone marrow#Proliferative Bone Marrow Failure Syndromes|Bone marrow proliferation]]</div>}}
 {{Family tree | |,|-|^|-|.| | | |,|-|^|-|.| | | |,|-|^|-|.| | | | }}
-{{Family tree |boxstyle= padding: 0; background: #DCDCDC; | D01 | | D02 | | D03 | | D04 | | D05 | | D06 | | | D01= Myelosuppression| D02= Immunosuppression| D03= Myeloproliferative| D04= Immunoproliferative| D05= Multiple lineages| D06= Single lineage}}
+{{Family tree |boxstyle= padding: 0; background: #DCDCDC; | D01 | | D02 | | D03 | | D04 | | D05 | | D06 | | | D01= [[Acquired disorders of the bone marrow#Bone Marrow Suppression|Myelosuppression]]| D02= [[Acquired disorders of the bone marrow#Bone Marrow Suppression|Immunosuppression]]| D03= [[Acquired disorders of the bone marrow#Bone Marrow Proliferation|Myeloproliferation]]| D04= [[Acquired disorders of the bone marrow#Bone Marrow Proliferation|Immunoproliferation]]| D05= [[Congenital disorders of the bone marrow#Multiple Lineages Defect|Multiple lineages]]| D06= [[Congenital disorders of the bone marrow#Single Lineage Defect|Single lineage]]}}
 {{Family tree/end}}