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| {{Atorvastatin}}
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| '''''For patient information, click [[Atorvastatin (patient information)|here]]'''''.
| | ===[[Atorvastatin calcium]] ([[Atorvastatin calcium|Lipitor]])=== |
| | ===[[Amlodipine besylate/Atorvastatin calcium]]=== |
| | ===[[Amlodipine/Atorvastatin]]=== |
| | ===[[Ezetimibe/Atorvastatin]]=== |
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| ==Overview== | | ==Overview== |
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| Atorvastatin is a member of the drug class known as [[statins]], used for lowering blood [[cholesterol]]. It also stabilizes plaque and prevents [[stroke]]s through anti-inflammation and other mechanisms. Like all statins, atorvastatin works by inhibiting [[HMG-CoA reductase]], an enzyme found in liver tissue that plays a key role in production of [[cholesterol]] in the body. | | Atorvastatin is a HMG-COA Reductase Inhibitor drug that is FDA approved for the treatment of hyperlipidemia, prevention of cardiovascular disease. Adverse reactions include [[diarrhea]], [[arthralgia]], [[myalgia]], urinary tract infectious disease, [[nasopharyngitis]], pain, in extremity. |
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| ==Category== | | ==Category== |
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| Lipid-Lowering Agents, Statins
| | HMG-COA Reductase Inhibitor |
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| ==US Brand Names==
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| Lipitor<sup>®</sup>
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| ==FDA Package Insert==
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| ''' [[Atorvastatin indications and usage|Indications and Usage]]'''
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| '''| [[Atorvastatin dosage and administration|Dosage and Administration]]'''
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| '''| [[Atorvastatin contraindications|Contraindications]]'''
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| '''| [[Atorvastatin warnings|Warnings and Precautions]]'''
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| '''| [[Atorvastatin adverse reactions|Adverse Reactions]]'''
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| '''| [[Atorvastatin overdosage|Overdosage]]'''
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| '''| [[Atorvastatin description|Description]]'''
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| '''| [[Atorvastatin clinical pharmacology|Clinical Pharmacology]]'''
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| '''| [[Atorvastatin clinical studies|Clinical Studies]]'''
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| '''| [[Atorvastatin how supplied storage and handling|How Supplied/Storage and Handling]]'''
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| '''| [[Atorvastatin labels and packages|Labels and Packages]]'''
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| ==Mechanism of Action==
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| Atorvastatin is a selective, competitive inhibitor of [[HMG-CoA reductase]], the rate-limiting enzyme that converts 3-hydroxy-3-methylglutaryl-coenzyme A to [[mevalonate]], a precursor of [[cholesterol]].
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| In animal models, atorvastatin lowers plasma cholesterol and [[lipoprotein]] levels by inhibiting [[HMG-CoA reductase]] and [[cholesterol]] synthesis in the liver and by increasing the number of hepatic [[LDL receptor]]s on the cell surface to enhance uptake and catabolism of LDL; atorvastatin also reduces [[LDL]] production and the number of [[LDL]] particles.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = LIPITOR (ATORVASTATIN CALCIUM) TABLET, FILM COATED [PARKE-DAVIS DIV OF PFIZER INC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=c6e131fe-e7df-4876-83f7-9156fc4e8228#nlm34089-3 | publisher = | date = | accessdate = }}</ref>
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| ==References==
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| {{Reflist|2}}
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Atorvastatin is a HMG-COA Reductase Inhibitor drug that is FDA approved for the treatment of hyperlipidemia, prevention of cardiovascular disease. Adverse reactions include diarrhea, arthralgia, myalgia, urinary tract infectious disease, nasopharyngitis, pain, in extremity.
Category
HMG-COA Reductase Inhibitor