M2 AML: Difference between revisions
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==Overview== | ==Overview== | ||
'''M2''' is a subtype of [[Acute myeloid leukemia|AML]] (Acute Myeloid Leukemia). | '''M2''' is a subtype of [[Acute myeloid leukemia|AML]] (Acute Myeloid Leukemia). | ||
This | ==Pathophysiology== | ||
This subtype is characterized by a [[translocation]] of a part of chromosome 8 to chromosome 21, written as t(8;21). On both sides of the chromosome, now containing pieces from two chromosomes, the DNA codes for different proteins. These two proteins are now being created as one single large protein, with a different effect in the body as the two proteins originally coded by the two different chromosomes. | |||
The two different proteins that are fused together are: | The two different proteins that are fused together are: | ||
*[[RUNX1]] | *[[RUNX1]] | ||
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{{Hematological malignancy histology}} | {{Hematological malignancy histology}} | ||
[[Category:Hematology]] | [[Category:Hematology]] | ||
[[Category:Types of cancer]] | [[Category:Types of cancer]] | ||
[[Category:Disease]] | [[Category:Disease]] | ||
Latest revision as of 19:11, 24 August 2015
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| ICD-O: | 9874/3 |
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WikiDoc Resources for M2 AML |
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Articles |
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Media |
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Evidence Based Medicine |
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Clinical Trials |
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Ongoing Trials on M2 AML at Clinical Trials.gov Clinical Trials on M2 AML at Google
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Guidelines / Policies / Govt |
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US National Guidelines Clearinghouse on M2 AML
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Books |
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News |
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Commentary |
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Definitions |
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Patient Resources / Community |
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Directions to Hospitals Treating M2 AML Risk calculators and risk factors for M2 AML
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Healthcare Provider Resources |
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Continuing Medical Education (CME) |
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International |
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Business |
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Experimental / Informatics |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
M2 is a subtype of AML (Acute Myeloid Leukemia).
Pathophysiology
This subtype is characterized by a translocation of a part of chromosome 8 to chromosome 21, written as t(8;21). On both sides of the chromosome, now containing pieces from two chromosomes, the DNA codes for different proteins. These two proteins are now being created as one single large protein, with a different effect in the body as the two proteins originally coded by the two different chromosomes. The two different proteins that are fused together are:
- RUNX1
- ETO