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| {{Squamous cell carcinoma}}
| | #redirect:[[Squamous cell carcinoma of the skin classification#Classification]] |
| {{CMG}}; '''Associate Editor(s)-in-Chief:''' [[User:Aditya Govindavarjhulla|Aditya Govindavarjhulla, M.B.B.S.]] [mailto:agovi@perfuse.org], [[User:Raviteja Reddy Guddeti|Raviteja Guddeti, M.B.B.S.]] [mailto:rgudetti@perfuse.org]
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| == Overview ==
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| [[Squamous cell carcinoma]] (SCC) is a slow growing invasive non-melanoma skin [[tumour]], which is caused mainly by prolonged exposure to sunlight and other forms of UV radiation. Patients undergo staging as a routine part of their diagnosis and treatment. Staging of the lesion assists the physician to choose which form of treatment strategy suits the patient. The following is the [[TNM]] staging recommended by the [[American Joint Committee on Cancer]] (AJCC) for cutaneous SCC.<ref>{{cite journal |author=Cobcroft R, Kronenberg H, Wilkinson T |title=Cryptococcus in bagpipes |journal=Lancet |volume=1 |issue=8078 |pages=1368–9 |year=1978 |month=June |pmid=78140 |doi= |url=}}</ref> | |
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| ==Classification==
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| {|style="width:80%; height:100px" border="1"
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| |style="height:100px"; style="width:25%" border="1" | '''Primary Tumour(T)'''
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''TX'''
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| |bgcolor="Beige"| Primary tumour cannot be assessed.
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''T0'''
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| |bgcolor="Beige"| No evidence of primary tumour.
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Tis'''
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| |bgcolor="Beige"| Carcinoma in situ.
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''T1'''
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| |bgcolor="Beige"|Tumour 2 cms or less in greatest dimension.
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| |-
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| |-bgcolor="LightSteelBlue"
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| | rowspan="3" | '''T2'''
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| |bgcolor="Beige"| Tumour greater than 2 cms in greatest dimesion.
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| |-
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| |bgcolor="Beige" | Or.
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| |-
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| |bgcolor="Beige" | Tumour any size with >= with high risk features.
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''T3'''
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| |bgcolor="Beige"|Tumour with invasion of maxilla, mandible, orbit or temporal bone.
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''T4'''
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| |bgcolor="Beige"|Tumour with invasion of skelton(axial or appendicular) or perineural invasion of skull base
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| |-
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| ----
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| {|style="width:80%; height:100px" border="1"
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| |style="height:100px"; style="width:25%" border="1" | '''High Risk Features For Primary Tumour(T) staging'''
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| |-
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| |-bgcolor="LightSteelBlue"
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| |rowspan ="3"| '''Depth/Invasion'''
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| |bgcolor="Beige"| > 2mm thickness
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| |-
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| |bgcolor="Beige"| Clark Level >= IV
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| |-
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| |bgcolor="Beige"| Perineural Invasion
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| |-
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| ----
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| {|style="width:80%; height:100px" border="1"
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| |style="height:100px"; style="width:25%" border="1" | '''Regional Lymph Nodes'''
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''NX'''
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| |bgcolor="Beige"| Regional lymph nodes cannot be assessed.
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''N0'''
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| |bgcolor="Beige"| No regional lymph node metastases.
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''N1'''
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| |bgcolor="Beige"| Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimesion.
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''N2'''
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| |bgcolor="Beige"| Metastasis is single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimesnion.
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''N2a'''
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| |bgcolor="Beige"| Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension.
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''N2b'''
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| |bgcolor="Beige"| Metastasis in multiple ipsilateral lymph nodes, more than 6 cm in greatest dimension.
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''N2c'''
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| |bgcolor="Beige"| Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''N3'''
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| |bgcolor="Beige"|Metastasis in a lymph node, more than 6 cm in greatest dimension.
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| |-
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| ----
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| {|style="width:35%; height:100px" border="1"
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| |style="height:100px"; style="width:25%" border="1" | '''Metastasis (M)'''
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| |-
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| |-bgcolor="LightSteelBlue"
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| | <center> '''M0''' </center>
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| |bgcolor="Beige"| <center> No distant Metastasis </center>
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| |-
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| |-bgcolor="LightSteelBlue"
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| | <center> '''M1''' </center>
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| |bgcolor="Beige"| <center> Distant Metastasis </center>
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| |-
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| ----
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| {| border="1" cellpadding="4"
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| |+ '''Cutaneous Squamous cell carcinoma'''
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| ! Grouping !! TNM staging
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| |-
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| | Stage 0
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| | Tis N0 M0
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| |-
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| | Stage I
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| | T1 N0 M0
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| |-
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| | Stage II
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| | T2 N0 M0
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| |-
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| |rowspan="4"| Stage III
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| | T3 N0 M0
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| |-
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| | T1 N1 M0
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| |-
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| | T2 N1 M0
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| |-
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| | T3 N1 M0
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| |-
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| |rowspan="6"| Stage IV
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| | T1 N2 M0
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| |-
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| | T2 N2 M0
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| |-
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| | T3 N2 M0
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| |-
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| | Any T N3 M0
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| |-
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| | T4 Any N M0
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| |-
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| | Any T Any N M1
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| |}
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