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| {{Infobox_Disease |
| | #Redirect [[Brain tumor]] |
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| DiseasesDB = |
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| ICD10 = |
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| {{Adult brain tumors}}
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| {{CMG}}
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| '''Associate Editor in Chief:''' {{CZ}}
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| ==[[Adult brain tumors overview|Overview]]==
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| ==[[Adult brain tumors historical perspective|Historical Perspective]]==
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| ==[[Adult brain tumors classification|Classification]]==
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| ==[[Adult brain tumors pathophysiology|Pathophysiology]]==
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| ==[[Adult brain tumors causes|Causes]]==
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| ==[[Adult brain tumors differential diagnosis|Differentiating Adult brain tumors from other Diseases]]==
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| ==[[Adult brain tumors epidemiology and demographics|Epidemiology and Demographics]]==
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| ==[[Adult brain tumors risk factors|Risk Factors]]==
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| ==[[Adult brain tumors screening|Screening]]==
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| ==[[Adult brain tumors natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
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| ==Diagnosis==
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| [[Adult brain tumors history and symptoms|History and Symptoms]] | [[Adult brain tumors physical examination|Physical Examination]] | [[Adult brain tumors laboratory findings|Laboratory Findings]] | [[Adult brain tumors electrocardiogram|EKG]] | [[Adult brain tumors chest x ray|Chest X ray]] | [[Adult brain tumors CT|CT]] | [[Adult brain tumors MRI|MRI]] | [[Adult brain tumors echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Adult brain tumors other imaging findings|Other Imaging Findings]] | [[Adult brain tumors other diagnostic studies|Other Diagnostic Studies]]
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| ==Treatment==
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| [[Adult brain tumors medical therapy|Medical Therapy]] | [[Adult brain tumors surgery|Surgery]] | [[Adult brain tumors primary prevention|Primary Prevention]] | [[Adult brain tumors secondary prevention|Secondary Prevention]] | [[Adult brain tumors cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Adult brain tumors future or investigational therapies|Future or Investigational Therapies]]
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| ==Case Studies==
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| [[Adult brain tumors case study one|Case #1]]
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| ==References==
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| {{refbegin|2}}
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| 1. Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000.
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| 2. Brain and spinal cord. In: American Joint Committee on Cancer.: AJCC Cancer Staging Manual. 6th ed. New York, NY: Springer, 2002, pp 387-90.
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| 3. Kleihues P, Burger PC, Scheithauer BW: The new WHO classification of brain tumours. Brain Pathol 3 (3): 255-68, 1993.
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| 4. Cavenee WK, Furnari FB, Nagane M, et al.: Diffusely infiltrating astrocytomas. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 10-21.
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| 5. Burger PC, Scheithauer BW, Paulus W, et al.: Pilocytic astrocytoma. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 45-51.
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| 6. Kleihues P, Davis RL, Ohgaki H, et al.: Diffuse astrocytoma. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 22-6.
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| 7. Kitange GJ, Templeton KL, Jenkins RB: Recent advances in the molecular genetics of primary gliomas. Curr Opin Oncol 15 (3): 197-203, 2003.
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| 8. Kleihues P, Davis RL, Coons SW, et al.: Anaplastic astrocytoma. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 27-8.
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| 9. Kleihues P, Burger PC, Collins VP, et al.: Glioblastoma. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 29-39.
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| 10. Kepes JJ, Louis DN, Giannini C, et al.: Pleomorphic xanthoastrocytoma. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 52-4.
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| 11. Wiestler OD, Lopes BS, Green AJ, et al.: Tuberous sclerosis complex and subependymal giant cell astrocytoma. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 227-30.
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| 12. Reifenberger G, Kros JM, Burger PC, et al.: Oligodendroglioma. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 56-61.
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| 13. Ueki K, Nishikawa R, Nakazato Y, et al.: Correlation of histology and molecular genetic analysis of 1p, 19q, 10q, TP53, EGFR, CDK4, and CDKN2A in 91 astrocytic and oligodendroglial tumors. Clin Cancer Res 8 (1): 196-201, 2002.
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| 14. Giordana MT, Ghimenti C, Leonardo E, et al.: Molecular genetic study of a metastatic oligodendroglioma. J Neurooncol 66 (3): 265-71, 2004.
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| 15. Kitange GJ, Smith JS, Jenkins RB: Genetic alterations and chemotherapeutic response in human diffuse gliomas. Expert Rev Anticancer Ther 1 (4): 595-605, 2001.
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| 16. Hoang-Xuan K, Capelle L, Kujas M, et al.: Temozolomide as initial treatment for adults with low-grade oligodendrogliomas or oligoastrocytomas and correlation with chromosome 1p deletions. J Clin Oncol 22 (15): 3133-8, 2004.
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| 17. Reifenberger G, Kros JM, Burger PC, et al.: Anaplastic oligodendroglioma. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 62-4.
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| 18. Cairncross JG, Ueki K, Zlatescu MC, et al.: Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas. J Natl Cancer Inst 90 (19): 1473-9, 1998.
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| 19. Ino Y, Betensky RA, Zlatescu MC, et al.: Molecular subtypes of anaplastic oligodendroglioma: implications for patient management at diagnosis. Clin Cancer Res 7 (4): 839-45, 2001.
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| 20. Reifenberger G, Kros JM, Burger PC, et al.: Oligoastrocytoma. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 65-7.
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| 21. Reifenberger G, Kros JM, Burger PC, et al.: Anaplastic oligoastrocytoma. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 68-9.
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| 22. Wiestler OD, Schiffer D, Coons SW, et al.: Myxopapillary ependymoma. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 78-9.
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| 23. Wiestler OD, Schiffer D: Subependymoma. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 80-1.
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| 24. Wiestler OD, Schiffer D, Coons SW, et al.: Ependymoma. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 72-6.
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| 25. Lantos PL, Rosenblum MK: Astroblastoma. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 88-9.
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| 26. Brat DJ, Scheithauer BW, Cortez SC, et al.: Chordoid glioma of the third ventricle. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 90-1.
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| 27. Lantos PL, Bruner JM: Gliomatosis cerebri. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 92-3.
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| 28. Nelson JS, Bruner JM, Wiestler OD, et al.: Ganglioglioma and gangliocytoma. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 96-8.
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| 29. Taratuto AL, VandenBerg SR, Rorke LB: Desmoplastic infantile astrocytoma and ganglioglioma. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 99-102.
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| 30. Daumas-Duport C, Pietsch T, Lantos PL: Dysembryoplastic neuroepithelial tumour. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 103-6.
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| 31. Figarella-Branger D, Soylemezoglu F, Kleihues P, et al.: Central neurocytoma. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 107-9.
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| 32. Leenstra JL, Rodriguez FJ, Frechette CM, et al.: Central neurocytoma: management recommendations based on a 35-year experience. Int J Radiat Oncol Biol Phys 67 (4): 1145-54, 2007.
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| 33. Kleihues P, Chimelli L, Giangaspero F: Cerebellar liponeurocytoma. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 110-1.
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| 34. Soffer D, Scheithauer BW: Paraganglioma. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 112-4.
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| 35. Becker LE, Cruz-Sanchez FF: Ependymoblastoma. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 127-8.
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| 36. Giangaspero F, Bigner SH, Kleihues P, et al.: Medulloblastoma. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 129-37.
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| 37. Brandes AA, Ermani M, Amista P, et al.: The treatment of adults with medulloblastoma: a prospective study. Int J Radiat Oncol Biol Phys 57 (3): 755-61, 2003.
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| 38. Rorke LB, Hart MN, McLendon RE: Supratentorial primitive neuroectodermal tumour (PNET). In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 141-4.
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| 39. Aguzzi A, Brandner S, Paulus W: Choroid plexus tumours. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 84-6.
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| 40. Mena H, Nakazato Y, Jouvet A, et al.: Pineocytoma. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 118-20.
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| 41. Mena H, Nakazato Y, Jouvet A, et al.: Pineoblastoma. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 116-8.
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| 42. Louis DN, Scheithauer BW, Budka H, et al.: Meningiomas. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, 176-84.
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| 43. Jääskeläinen J, Louis DN, Paulus W, et al.: Haemangiopericytoma. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 190-2.
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| 44. Jellinger K, Chou P, Paulus W: Melanocytic lesions. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 193-5.
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| 45. Rosenblum MK, Matsutani M, Van Meir EG: CNS germ cell tumors. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 208-14.
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| 49. Janzer RC, Burger PC, Giangaspero F, et al.: Craniopharyngioma. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 244-6.
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| 50. Böhling T, Plate KH, Haltia MJ, et al.: Von Hippel-Lindau disease and capillary haemangioblastoma. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 223-6.
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| 51. Woodruff JM, Kourea HP, Louis DN, et al.: Schwannoma. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 164-6.
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| 52. Wen PY, Black PM, Loeffler JS: Treatment of metastatic cancer. In: DeVita VT Jr, Hellman S, Rosenberg SA, eds.: Cancer: Principles and Practice of Oncology. 6th ed. Philadelphia, Pa: Lippincott Williams & Wilkins, 2001, pp 2655-70.
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| 53. Patchell RA: The management of brain metastases. Cancer Treat Rev 29 (6): 533-40, 2003.
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| 54. Nelson JS, Von Deimling A, Petersen I, et al.: Metastatic tumours of the CNS. In: Kleihues P, Cavenee WK, eds.: Pathology and Genetics of Tumours of the Nervous System. Lyon, France: International Agency for Research on Cancer, 2000, pp 250-3.
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