Sandbox parminder: Difference between revisions

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__NOTOC__
*Endocrine cells in insulinoma are organised in nests and trabecular pattern scattered throughout a fibro-vascular stroma with well-localised fibrous septa separating it from normal tissue<ref name="PadidelaFiest2014">{{cite journal|last1=Padidela|first1=R.|last2=Fiest|first2=M.|last3=Arya|first3=V.|last4=Smith|first4=V. V.|last5=Ashworth|first5=M.|last6=Rampling|first6=D.|last7=Newbould|first7=M.|last8=Batra|first8=G.|last9=James|first9=J.|last10=Wright|first10=N. B.|last11=Dunne|first11=M. J.|last12=Clayton|first12=P. E.|last13=Banerjee|first13=I.|last14=Hussain|first14=K.|title=Insulinoma in childhood: clinical, radiological, molecular and histological aspects of nine patients|journal=European Journal of Endocrinology|volume=170|issue=5|year=2014|pages=741–747|issn=0804-4643|doi=10.1530/EJE-13-1008}}</ref>
*Absence of exocrine tissue with the loss of normal pancreatic architecture




{{CMG}}; {{AE}} {{Sapan}}


==[[Type page name here overview|Overview]]==


==[[Type page name here historical perspective|Historical Perspective]]==
Patients with insulinomas usually develop neuroglycopenic symptoms.  These include recurrent headache, lethargy, [[diplopia]], and [[blurred vision]], particularly with exercise or fasting.  Severe [[hypoglycemia]] may result in [[seizure]]s, [[coma]], and permanent neurological damage.  Symptoms resulting from the catecholaminergic response to hypoglycemia (i.e. tremulousness, palpitations, [[tachycardia]], sweating, hunger, anxiety, nausea) are not as common.  Sudden weight gain (the patient can become massively obese) is sometimes seen. A neater list of symptoms would include:


==[[Type page name here classification|Classification]]==
* [[Anxiety]]
* Behavior changes
* [[Blurred vision]]
* [[Confusion]]
* [[Convulsions]]
* [[Dizziness]]
* [[Headache]]
* [[Hunger]]
* [[Loss of consciousness]]
* [[Rapid heart rate]]
* [[Sweating]]
* [[Tremor]]
* [[Weight gain]]


==[[Type page name here pathophysiology|Pathophysiology]]==


==[[Type page name here causes|Causes]]==


==[[Type page name here differential diagnosis|Differentiating Any Disease from other Diseases]]==
<ref name="pmid1356383">{{cite journal| author=| title=Proceedings of the 1991 International Congress of Rhinology. Tokyo, Japan. | journal=Rhinol Suppl | year= 1992 | volume= 14 | issue=  | pages= 1-273 | pmid=1356383 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1356383  }} </ref>
 
==[[Type page name here epidemiology and demographics|Epidemiology and Demographics]]==
 
==[[Type page name here risk factors|Risk Factors]]==
 
==[[Type page name here screening|Screening]]==
 
==[[Type page name here natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
 
==Diagnosis==
[[Type page name here history and symptoms|History and Symptoms]] | [[Type page name here physical examination|Physical Examination]] | [[Type page name here laboratory findings|Laboratory Findings]] | [[Type page name here electrocardiogram|Electrocardiogram]] |[[Type page name here chest x ray|Chest X Ray]] | [[Type page name here CT|CT]] | [[Type page name here MRI|MRI]] | | [[Type page name here other imaging findings|Other Imaging Findings]] | [[Type page name here other diagnostic studies|Other Diagnostic Studies]]
 
==Treatment==
[[Type page name here medical therapy|Medical Therapy]] | [[Type page name here surgery|Surgery]] | [[Type page name here primary prevention|Primary Prevention]] | [[Type page name here secondary prevention|Secondary Prevention]] | [[Type page name here cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Type page name here future or investigational therapies|Future or Investigational Therapies]]
 
==Case Studies==
[[Type page name here case study one|Case #1]]
 
 
[[Category:Projects]]
[[Category:Help]]
 
{{WH}}
{{WS}}

Latest revision as of 21:52, 2 October 2015


*Endocrine cells in insulinoma are organised in nests and trabecular pattern scattered throughout a fibro-vascular stroma with well-localised fibrous septa separating it from normal tissue[1]
  • Absence of exocrine tissue with the loss of normal pancreatic architecture



Patients with insulinomas usually develop neuroglycopenic symptoms. These include recurrent headache, lethargy, diplopia, and blurred vision, particularly with exercise or fasting. Severe hypoglycemia may result in seizures, coma, and permanent neurological damage. Symptoms resulting from the catecholaminergic response to hypoglycemia (i.e. tremulousness, palpitations, tachycardia, sweating, hunger, anxiety, nausea) are not as common. Sudden weight gain (the patient can become massively obese) is sometimes seen. A neater list of symptoms would include:


[2]

  1. ↑ Padidela, R.; Fiest, M.; Arya, V.; Smith, V. V.; Ashworth, M.; Rampling, D.; Newbould, M.; Batra, G.; James, J.; Wright, N. B.; Dunne, M. J.; Clayton, P. E.; Banerjee, I.; Hussain, K. (2014). "Insulinoma in childhood: clinical, radiological, molecular and histological aspects of nine patients". European Journal of Endocrinology. 170 (5): 741–747. doi:10.1530/EJE-13-1008. ISSN 0804-4643.
  2. ↑ "Proceedings of the 1991 International Congress of Rhinology. Tokyo, Japan". Rhinol Suppl. 14: 1–273. 1992. PMID 1356383.
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