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* Chronic lymphocytic leukemia must be differentiated from other diseases that cause weight loss,  night sweats, hepatosplenomegaly, and palpable lymph nodes, such as hairy cell leukaemia, prolymphocytic leukaemia, follicular lymphoma, and mantle cell lymphoma.
*The table below lists the risk factors for chronic lymphocytic leukmeia development:<ref name="gov">What are the risk factors for chronic lymphocytic leukemia? American Cancer Society (2015) http://www.cancer.org/cancer/leukemia-chroniclymphocyticcll/detailedguide/leukemia-chronic-lymphocytic-risk-factors Accessed on October, 12 2015</ref><ref> Chronic Lymphocytic Leukemia. Mayoclinic (2015) http://www.mayoclinic.org/diseases-conditions/chronic-lymphocytic-leukemia/basics/risk-factors/con-20031195 Accessed on October, 12 2015</ref>
* The table below summarizes how to differentiate chronic lymphocytic leukemia from other conditions that cause similar presentation:<ref>Hoffbrand V, Moss P. Essential Haematology. John Wiley & Sons; 2011</ref>
 
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{| style="border: 0px; font-size: 90%; margin: 3px; width: 1000px"
{| style="cellpadding=0; cellspacing= 0; width: 1100px;"
|valign=top|
|-
|+
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! style="background: #4479BA; width: 600px;" | {{fontcolor|#FFF|'''Differential Diagnosis'''}}
! style="background: #4479BA; width: 200px; color: #FFFFFF;"|'''Risk Factor'''
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''Surface Immunoglobulin'''}}
 
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''CD5'''}}
! style="background: #4479BA; width: 600px; color: #FFFFFF;"|'''Description'''
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''CD22/FMC7'''}}
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''CD23'''}}
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''CD79b'''}}
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|'''CD103'''}}


|-
|-


| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | '''Age'''|| style="padding: 5px 5px; background: #F5F5F5;" |The risk to develop chronic lymphocytic leukemia increases as patients advance in age.
'''Chronic lymphocytic leukaemia'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center |
'''Weakly positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center |
'''Positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center |
'''Negative'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Negative'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Positive/Negative'''


|-
|-


| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | '''Gender'''|| style="padding: 5px 5px; background: #F5F5F5;" |Males are more commonly affected with chronic lymphocytic leukemia than females]
'''Prolymphocytic leukaemia'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Strongly positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Negative'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Negative'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Negative'''


|-
|-


| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | '''Family history'''|| style="padding: 5px 5px; background: #F5F5F5;" |First-degree relatives of chronic lymphocytic leukemia patients have an increased risk to develop to the disease.
'''Hairy cell leukaemia'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Strongly positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Negative'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Negative'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Positive/Negative'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Positive'''


|-
|-


| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | '''Chemical exposure'''|| style="padding: 5px 5px; background: #F5F5F5;" |Exposure to [[herbicide]]s and [[insecticide]]s (used in farming) are correlated with an increased risk of chronic lymphocytic leukemia.
'''Mantle cell lymphoma'''
|-
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Strongly positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
Negative
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Strongly positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Negative'''


|-
|-


| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | '''Race'''|| style="padding: 5px 5px; background: #F5F5F5;" |The risk to develop chronic lymphocytic leukemia increases among individuals of Caucasian race.
'''Follicular lymphoma'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Strongly positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Negative'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Negative'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Strongly positive'''
| style="padding: 5px 5px; background: #F5F5F5;" align=center|
'''Negative'''
|}
|}
<br>
* Chronic lymphocytic leukemia must also be differentiated from other causes of fever, hepatosplenomegaly, and lymph node swelling such as:
:* Splenic marginal zone lymphoma
:* Nodal marginal zone lymphoma
:* Lymphoplasmacytic lymphoma
:* Sézary syndrome
:* Smoldering adult T cell leukemia<ref name="wiki>Chronic Lymphocytic Leukimea. Wikipedia (2015) https://en.wikipedia.org/wiki/B-cell_chronic_lymphocytic_leukemia Accessed on October ,12 2015</ref>

Latest revision as of 23:00, 13 October 2015

  • The table below lists the risk factors for chronic lymphocytic leukmeia development:[1][2]
Risk Factor Description
Age The risk to develop chronic lymphocytic leukemia increases as patients advance in age.
Gender Males are more commonly affected with chronic lymphocytic leukemia than females]
Family history First-degree relatives of chronic lymphocytic leukemia patients have an increased risk to develop to the disease.
Chemical exposure Exposure to herbicides and insecticides (used in farming) are correlated with an increased risk of chronic lymphocytic leukemia.
Race The risk to develop chronic lymphocytic leukemia increases among individuals of Caucasian race.
  1. ↑ What are the risk factors for chronic lymphocytic leukemia? American Cancer Society (2015) http://www.cancer.org/cancer/leukemia-chroniclymphocyticcll/detailedguide/leukemia-chronic-lymphocytic-risk-factors Accessed on October, 12 2015
  2. ↑ Chronic Lymphocytic Leukemia. Mayoclinic (2015) http://www.mayoclinic.org/diseases-conditions/chronic-lymphocytic-leukemia/basics/risk-factors/con-20031195 Accessed on October, 12 2015
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