Sandbox:DDx HEENT: Difference between revisions

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* 65 yo women
* Anemia and lymphopenia
* Rapidly enlarging neck mass
* Eosinophilia and neutrophiliae
* Neck pain, dyspnea, dysphagia, and hoarseness
* Positive warm-agglutinin  antibodies
* Constitutional symptoms
* Elevated LDH and creatinine concentration
 
* Tender hard nodular goiter
* Extensive lymphadenopathy
 
* Pleomorphic giant cells separated by connective tissue septae
* Cavernous blood filled sinuses resembling aneurysmal bone cyst
* Spindle cells resembling sarcoma
* Squamoid cells that are relatively undifferentiated but also appear epithelial with occasional focal keratinization
 
Patterns are often mixed with better differentiated cells palisading at necrotic edges and with precursor well differentiated carcinoma;
Necrosis
Vascular invasion
Increased mitotic activity
Rhabdoid inclusions
 
* BRAF gene mutation
* p53 gene mutation

Latest revision as of 20:51, 4 November 2015

  • Anemia and lymphopenia
  • Eosinophilia and neutrophiliae
  • Positive warm-agglutinin antibodies
  • Elevated LDH and creatinine concentration
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