Essential thrombocytosis (patient information): Difference between revisions
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==Overview== | ==Overview== | ||
Primary thrombocythemia is a condition in which the bone marrow produces too many platelets. Platelets are a part of the blood that aids in blood clotting. | Primary thrombocythemia is a condition in which the bone marrow produces too many platelets. Platelets are a part of the blood that aids in blood clotting. | ||
==What are the symptoms of Essential thrombocytosis?== | ==What are the symptoms of Essential thrombocytosis?== | ||
Symptoms may include any of the following: | *Symptoms may include any of the following: | ||
Bleeding from the gastrointestinal tract, respiratory system, urinary tract, or skin | :*Bleeding from the gastrointestinal tract, respiratory system, urinary tract, or skin | ||
Bleeding from the gums | :*Bleeding from the gums | ||
Bleeding (prolonged) from surgical procedures or tooth removal | :*Bleeding (prolonged) from surgical procedures or tooth removal | ||
Dizziness and headaches | :*Dizziness and headaches | ||
Easy bruising and nosebleeds (epistaxis) | :*Easy bruising and nosebleeds (epistaxis) | ||
Numbness of the hands or feet | :*Numbness of the hands or feet | ||
Ulcers on the fingers or toes | :*Ulcers on the fingers or toes | ||
The condition can even cause strokes in some people. | *The condition can even cause strokes in some people. | ||
==What causes Essential thrombocytosis?== | ==What causes Essential thrombocytosis?== | ||
Primary thrombocythemia is caused by the overproduction of platelets. If untreated, this condition gets worse over time. Because these platelets do not work normally, bleeding is a common problem. | *Primary thrombocythemia is caused by the overproduction of platelets. If untreated, this condition gets worse over time. Because these platelets do not work normally, bleeding is a common problem. | ||
The disease is part of a group of conditions known as myeloproliferative disorders. Others include: | *The disease is part of a group of conditions known as myeloproliferative disorders. Others include: | ||
Chronic myelogenous leukemia | :*Chronic myelogenous leukemia | ||
Polycythemia vera | :*Polycythemia vera | ||
Primary myelofibrosis | :*Primary myelofibrosis | ||
This disorder is most common in middle aged people. It can also be seen in younger people, especially women under age 40. | *This disorder is most common in middle aged people. It can also be seen in younger people, especially women under age 40. | ||
==Who is at highest risk?== | ==Who is at highest risk?== | ||
==Diagnosis== | ==Diagnosis== | ||
*Most of the time, this condition is found through blood tests done for other conditions before symptoms appear. | |||
*Your health care provider may notice an enlarged liver or spleen on physical examination. You may also have abnormal blood flow in the toes or feet that causes skin damage in these areas. | |||
*Other tests may include: | |||
:*Bone marrow biopsy | |||
:*CBC | |||
:*Genetic tests (to look for a change in the JAK2 gene) | |||
:*Uric acid level | |||
==When to seek urgent medical care?== | ==When to seek urgent medical care?== | ||
*Call your health care provider if: | |||
:*You have unexplained bleeding that continues longer than it should. | |||
:*You notice chest pain, leg pain, confusion, weakness, numbness, or other new symptoms. | |||
==Treatment options== | ==Treatment options== | ||
*If you have life-threatening complications, you may have a treatment called platelet pheresis. It quickly reduces platelets in the blood. | |||
*Long-term, medicines are used to decrease the platelet count to avoid complications. The most common medicines used include hydroxyurea, interferon-alpha, or anagrelide. In some people with a JAK2 mutation, specific inhibitors of the JAK2 protein may be used. | |||
*In people who are at a high risk for clotting, aspirin at a low dose (81 to 100 mg per day) decreases clotting episodes. People who may benefit from this treatment include older people and people with very high platelet levels or who have had past clotting episodes. | |||
*Many people do not need any treatment, but they must be followed closely by their provider. | |||
==Where to find medical care for Essential thrombocytosis?== | ==Where to find medical care for Essential thrombocytosis?== | ||
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==What to expect (Outlook/Prognosis)?== | ==What to expect (Outlook/Prognosis)?== | ||
*While outcomes can vary, most people can go for long periods without complications and have a normal lifespan. In a small number of people, complications from bleeding and blood clots can cause serious problems. | |||
*In rare cases, the disease can change into acute leukemia or myelofibrosis. | |||
==Possible complications== | ==Possible complications== | ||
*Complications may include: | |||
:*Acute leukemia or myelofibrosis | |||
:*Severe bleeding (hemorrhage) | |||
:*Thrombotic episodes (stroke, heart attack, or blood clots in the hands or feet) | |||
==Sources== | ==Sources== | ||
Latest revision as of 21:53, 12 November 2015
For the WikiDoc page on this topic, click here
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Essential thrombocytosis |
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Essential thrombocytosis On the Web |
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Risk calculators and risk factors for Essential thrombocytosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Primary thrombocythemia is a condition in which the bone marrow produces too many platelets. Platelets are a part of the blood that aids in blood clotting.
What are the symptoms of Essential thrombocytosis?
- Symptoms may include any of the following:
- Bleeding from the gastrointestinal tract, respiratory system, urinary tract, or skin
- Bleeding from the gums
- Bleeding (prolonged) from surgical procedures or tooth removal
- Dizziness and headaches
- Easy bruising and nosebleeds (epistaxis)
- Numbness of the hands or feet
- Ulcers on the fingers or toes
- The condition can even cause strokes in some people.
What causes Essential thrombocytosis?
- Primary thrombocythemia is caused by the overproduction of platelets. If untreated, this condition gets worse over time. Because these platelets do not work normally, bleeding is a common problem.
- The disease is part of a group of conditions known as myeloproliferative disorders. Others include:
- Chronic myelogenous leukemia
- Polycythemia vera
- Primary myelofibrosis
- This disorder is most common in middle aged people. It can also be seen in younger people, especially women under age 40.
Who is at highest risk?
Diagnosis
- Most of the time, this condition is found through blood tests done for other conditions before symptoms appear.
- Your health care provider may notice an enlarged liver or spleen on physical examination. You may also have abnormal blood flow in the toes or feet that causes skin damage in these areas.
- Other tests may include:
- Bone marrow biopsy
- CBC
- Genetic tests (to look for a change in the JAK2 gene)
- Uric acid level
When to seek urgent medical care?
- Call your health care provider if:
- You have unexplained bleeding that continues longer than it should.
- You notice chest pain, leg pain, confusion, weakness, numbness, or other new symptoms.
Treatment options
- If you have life-threatening complications, you may have a treatment called platelet pheresis. It quickly reduces platelets in the blood.
- Long-term, medicines are used to decrease the platelet count to avoid complications. The most common medicines used include hydroxyurea, interferon-alpha, or anagrelide. In some people with a JAK2 mutation, specific inhibitors of the JAK2 protein may be used.
- In people who are at a high risk for clotting, aspirin at a low dose (81 to 100 mg per day) decreases clotting episodes. People who may benefit from this treatment include older people and people with very high platelet levels or who have had past clotting episodes.
- Many people do not need any treatment, but they must be followed closely by their provider.
Where to find medical care for Essential thrombocytosis?
Directions to Hospitals Treating Essential thrombocytosis
Prevention of Essential thrombocytosis
What to expect (Outlook/Prognosis)?
- While outcomes can vary, most people can go for long periods without complications and have a normal lifespan. In a small number of people, complications from bleeding and blood clots can cause serious problems.
- In rare cases, the disease can change into acute leukemia or myelofibrosis.
Possible complications
- Complications may include:
- Acute leukemia or myelofibrosis
- Severe bleeding (hemorrhage)
- Thrombotic episodes (stroke, heart attack, or blood clots in the hands or feet)