Sandbox: Bone DDx: Difference between revisions

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* 10-20 yo patients
* 55-60 yo males
* Asymptomatic
* Back pain
* Pathologic fractures
* Pathological fracture
* Palpable vertebral mass


* Often Unremarkable


* No specific lab finding
* Discrete, solitary mass male 55 years
* Pain at the site of the skeletal lesion
* Bone destruction


*  Cysts contain clear serosanguineous fluid
* Well-defined, “punched-out” lytic lesions
* Fibrous membranous lining
* Marked erosion, expansion, and destruction of bone cortex
 
* Thick ridging around the periphery
* Well defined geographic lucent lesions on Xray
* “Soap bubble” appearance
* Sclerotic margin
* No periosteal reaction
* Thinning of the endosteum and pseudotrabeculation
 
* TP53 mutations

Latest revision as of 20:27, 24 November 2015

  • 55-60 yo males
  • Back pain
  • Pathological fracture
  • Palpable vertebral mass


  • Discrete, solitary mass male 55 years
  • Pain at the site of the skeletal lesion
  • Bone destruction
  • Well-defined, “punched-out” lytic lesions
  • Marked erosion, expansion, and destruction of bone cortex
  • Thick ridging around the periphery
  • “Soap bubble” appearance
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