Sandbox: Bone DDx: Difference between revisions

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* 55-60 yo males
* Back pain
* Pathological fracture
* Palpable vertebral mass


* 30-60 yo males


* Highly destructive with a wide zone of transition
* Discrete, solitary mass male 55 years
* Expansile large soft tissue mass extending from the bone
* Pain at the site of the skeletal lesion
* Periosteal reaction is uncommon
* Bone destruction


* Elevated mitotic activity
* Well-defined, “punched-out” lytic lesions
* Highly cellular fibroblastic proliferation
* Marked erosion, expansion, and destruction of bone cortex
* Herring bone pattern and spindle cell lesions
* Thick ridging around the periphery
* Long dark nuclei with increased granular chromatin
* “Soap bubble” appearance
* Scant cytoplasm

Latest revision as of 20:27, 24 November 2015

  • 55-60 yo males
  • Back pain
  • Pathological fracture
  • Palpable vertebral mass


  • Discrete, solitary mass male 55 years
  • Pain at the site of the skeletal lesion
  • Bone destruction
  • Well-defined, “punched-out” lytic lesions
  • Marked erosion, expansion, and destruction of bone cortex
  • Thick ridging around the periphery
  • “Soap bubble” appearance