Sandbox: Bone DDx: Difference between revisions

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* 20-30 yo female
* 55-60 yo males
* Bone pain and swelling
* Back pain
* Pathologic fracture
* Pathological fracture  
* Paget disease of bone
* Palpable vertebral mass


* Localised bone tenderness


* Epiphyses of the long bones
* Discrete, solitary mass male 55 years
* Solitary expansile eccentrically-placed lytic lesion
* Pain at the site of the skeletal lesion
* Intratumoral hemorrhage present
* Bone destruction
* Tumor extends into the subchondral plate


* Uniform and regular distribution of multinucleated giant cells and mononuclear stromal cells
* Well-defined, “punched-out” lytic lesions
* Hemorrhage, necrosis, and hemosiderin deposition
* Marked erosion, expansion, and destruction of bone cortex
* Elevated mitotic figures
* Thick ridging around the periphery
 
* “Soap bubble” appearance
 
acid phosphatase +ve
alpha-1-antitrypsin +ve
alpha-1-antichymotrypsin +ve
Ki-67 +ve

Latest revision as of 20:27, 24 November 2015

  • 55-60 yo males
  • Back pain
  • Pathological fracture
  • Palpable vertebral mass


  • Discrete, solitary mass male 55 years
  • Pain at the site of the skeletal lesion
  • Bone destruction
  • Well-defined, “punched-out” lytic lesions
  • Marked erosion, expansion, and destruction of bone cortex
  • Thick ridging around the periphery
  • “Soap bubble” appearance
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