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'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''.
'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''.


{{CMG}}
{{CMG}}; {{AE}} {{SC}}


{{SK}}
{{SK}} Multilocular cystic nephroma, Mixed epithelial stromal tumor, Renal epithelial stromal tumor


==[[Cystic nephroma overview|Overview]]==
==[[Cystic nephroma overview|Overview]]==
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==[[Cystic nephroma screening|Screening]]==
==[[Cystic nephroma screening|Screening]]==


==[[Cystic nephroma natural history|Natural History, Complications and Prognosis]]==
==[[Cystic nephroma natural history, complications and prognosis|Natural History, Complications and Prognosis]]==


==Diagnosis==
==Diagnosis==
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[[Category:Disease]]
[[Category:Disease]]
[[Category:Types of cancer]]
[[Category:Types of cancer]]
==Overview==
A '''cystic nephroma''', also known as '''multilocular cystic nephroma''', '''mixed epithelial stromal tumour (MEST)''' and '''renal epithelial stromal tumour (REST)''',<ref name=pmid17414095>{{cite journal  |vauthors=Turbiner J, Amin MB, Humphrey PA, etal |title=Cystic nephroma and mixed epithelial and stromal tumor of kidney: a detailed clinicopathologic analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying term |journal=Am. J. Surg. Pathol. |volume=31 |issue=4 |pages=489–500 |date=April 2007 |pmid=17414095 |doi=10.1097/PAS.0b013e31802bdd56 |url=}}</ref> is a type of rare [[benign tumor|benign]] [[kidney tumour]].
==Symptoms==
Cystic nephromas are often asymptomatic.  They are typically discovered on [[medical imaging]] incidentally (i.e. an [[incidentaloma]]).
==Diagnosis==
Cystic nephromas are diagnosed by [[biopsy]] or excision.  It is important to correctly diagnose them as, radiologically, they may mimic the appearance of a [[renal cell carcinoma]] that is cystic.<ref>Small JE et al. Cystic Nephroma. BrighamRAD Teaching Case Database. URL: [http://brighamrad.harvard.edu/Cases/bwh/hcache/385/full.html http://brighamrad.harvard.edu/Cases/bwh/hcache/385/full.html]. Accessed: July 25, 2009.</ref>
===Pathologic diagnosis===
[[Image:Cystic nephroma high mag.jpg|thumb|right|250px|High magnification micrograph of a '''cystic nephroma''' showing the characteristic [[simple epithelium]] with hobnail morphology, and the [[ovary|ovarian]]-like [[stroma of ovary|stroma]]. [[H&E stain]].]]
The characteristics of cystic nephromas are:
*[[Cyst]]s lined by a simple epithelium with a ''hobnail morphology'', i.e. the nuclei of the cyst lining epithelium bulges into the lumen of the cysts,
*[[w:ovary|Ovarian]]-like [[stroma (animal tissue)|stroma]] that has a:
**[[w:spindle cell|Spindle cell]] morphology, and has a
**Basophilic [[w:cytoplasm|cytoplasm]].
Cystic nephromas have an immunostaining pattern like ovarian stroma; they are positive for:
*[[w:Estrogen receptor|Estrogen receptor (ER)]],
*[[w:Progesterone receptor|Progesterone receptor (PR)]] and
*[[w:CD10|CD10]].
===Differential diagnosis===
*[[cystic partially differentiated nephroblastoma]]
*cystic standard nephroblastoma (cystic [[Wilm's tumor]])
*cystic [[mesoblastic nephroma]]
*cystic [[renal cell carcinoma]]
*other [[renal cyst]]s
==References==
{{reflist|2}}


{{Urologic neoplasia}}
{{Urologic neoplasia}}

Latest revision as of 15:09, 30 November 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]

Synonyms and keywords: Multilocular cystic nephroma, Mixed epithelial stromal tumor, Renal epithelial stromal tumor

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Cystic nephroma

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Staging | History and Symptoms | Physical Examination | Laboratory Findings | X Ray | CT | MRI Ultrasound | Other Imaging Findings | Other Diagnostic Studies | Biopsy

Treatment

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