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| __NOTOC__
| | #redirect [[Lassa virus]] |
| {{Lassa fever}}
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| {{CMG}}
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| ==Overview==
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| ==Causes==
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| Lassa fever is caused by the ''Lassa virus'', a member of the [[Arenaviridae]] family; it is an enveloped, single-stranded, bisegmented [[RNA]] virus.
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| Replication for Lassa virus is very rapid, while also demonstrating temporal control in replication. There are two [[genome]] segments. The first step involved is making [[messenger RNA|mRNA]] copies of the - sense genome. This ensures that there is adequate proteins, which are required for replication. The N and L proteins are made from the mRNA produced. The - sense genome then makes [[viral circular RNA|vcRNA]] copies of itself which are + sense. The vcRNA is a template for producing - sense progeny but mRNA is also synthesized from it. The mRNA synthesized from vcRNA translate the G (spike) proteins and Z proteins. Thus, with this temporal control, the spike proteins are produced last, making the infection further undetected by the host immune system.
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| Lassa virus will infect just about every tissue in the human body. It starts with the [[mucosa]], intestine, lungs and urinary systems, and then progresses to the vascular system. | |
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| ==References==
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| {{Reflist|2}}
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| [[Category:Disease]]
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| [[Category:Viral diseases]]
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| [[Category:Viruses]]
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| [[Category:Zoonoses]]
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| [[Category:Hemorrhagic fevers]]
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| [[Category:Tropical disease]]
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| [[Category:Biological weapons]]
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| [[Category:Infectious disease]]
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