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| __NOTOC__
| | #redirect [[Lassa virus]] |
| {{Lassa fever}}
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| {{CMG}}
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| ==Overview==
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| Lassa fever is caused by the ''Lassa virus'', a member of the [[Arenaviridae]] family; it is an [[enveloped virus|enveloped]], single-stranded, bisegmented [[RNA]] virus. [[viral replication|Replication]] for Lassa virus is very rapid, while also demonstrating temporal control in replication. There are two [[genome]] segments. The first step involved is making [[messenger RNA|mRNA]] copies of the negative-sense [[genome]]. This ensures that there are adequate [[protein]]s, which are required for [[replication]]. The N and L proteins are made from the mRNA produced. The -ve sense genome then makes vcRNA (viral circular RNA) copies of itself which are positive-sense. The vcRNA is a [[template strand|template]] for producing -ve sense progeny but mRNA is also synthesized from it. The mRNA synthesized from vcRNA [[translation (biology)|translates]] the [[G proteins|G (spike) proteins]] and Z proteins. Thus, with this temporal control, the spike proteins are produced last, making the infection further undetected by the [[host (biology)|host]] [[immune system]].
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| ==References==
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| {{Reflist|2}}
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| [[Category:Disease]]
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| [[Category:Viral diseases]]
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| [[Category:Viruses]]
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| [[Category:Zoonoses]]
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| [[Category:Hemorrhagic fevers]]
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| [[Category:Tropical disease]]
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| [[Category:Biological weapons]]
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| [[Category:Infectious disease]]
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| [[Category:Needs content]]
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