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| __NOTOC__
| | #redirect [[Cutaneous T cell lymphoma]] |
| {{DiseaseDisorder infobox |
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| Name = Sézary's disease |
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| ICD10 = {{ICD10|C|84|1|c|81}} |
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| ICD9 = {{ICD9|202.2}} |
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| ICDO = {{ICDO|9701|3}} |
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| Image = Sezary syndrome 0001.jpg|
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| Caption = Sézary's disease. <br> (Image courtesy of Melih Aktan MD, Istanbul Medical Faculty - Turkey)|
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| OMIM = |
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| MedlinePlus = |
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| eMedicineSubj = |
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| eMedicineTopic = |
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| DiseasesDB = 8595 |
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| MeshID = D012751 |
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| }}
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| {{Sezary's disease}}
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| {{CMG}}
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| {{SK}} Cutaneous T-cell lymphoma; mycosis fungoides; sezary syndrome
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| ==Overview==
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| '''Sézary's disease''' (or "Sézary syndrome") is a type of cutaneous [[lymphoma]] characterized by Albert Sézary. <ref>{{WhoNamedIt|synd|3594}}</ref>. "Sézary's cells" are [[T-cells]] that have pathological quantities of [[mucopolysaccharide]]s. Sézary's disease is sometimes considered a late stage of [[mycosis fungoides]]. Sezary syndrome and Mycosis Fungoides are T-cell lymphomas whose primary manifestation is in the skin.
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| ==Etiology==
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| HTLV has thought to have been associated with both of the above cutaneous mycoses.
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| ==Symptoms==
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| The hallmark symptoms for Sézary's disease are
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| # Generalized [[erythroderma]]
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| # [[Lymphadenopathy ]]
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| # Atypical T-cells ("Sezary cells") in the peripheral blood.
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| ==Treatment==
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| [[Vorinostat]] '''(Zolinza®)''' is a second-line drug for CTCL. Treatments are often used in combination.
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| ==References==
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| <references/>
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| ==External links==
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| * [http://www.wadsworth.org/chemheme/heme/glass/slide_015_sezary.htm Illustration of Sezary cells]
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| * [http://www.bium.univ-paris5.fr/sfhd/biographies/sezary.htm Biography of Sezary (in French)]
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| * [http://www.lymphomainfo.net/nhl/types/ctcl-mf.html Sezary Syndrome lymphoma information]
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| * [http://www.thedoctorsdoctor.com/diseases/sezary_syndrome.htm Doctor's doctor]
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| * [http://www.clfoundation.org Cutaneous Lymphoma Foundation ]
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| * [http://www.clinicaltrials.gov/ct/show/NCT00106431 Clinical Trial for Sezary Syndrome
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| * {{GPnotebook|584056846}}
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| {{Hematological malignancy histology}}
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| [[Category:Hematology]]
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| [[Category:Types of cancer]]
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| [[Category:Oncology]]
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| [[Category:Oncology stub]]
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| [[de:Sézary-Syndrom]]
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| [[ja:セザリー症候群]]
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| [[pl:Zespół Sézary'ego]]
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| [[pt:Síndrome de Sézary]]
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