Evans syndrome laboratory findings: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Evans syndrome}} | {{Evans syndrome}} | ||
{{CMG}} | {{CMG}}; {{AE}} {{Ammu}} | ||
==Overview== | ==Overview== | ||
Laboratory findings consistent with the diagnosis of Evans syndrome include [[anemia]], direct coombs test positive, and antineutrophil antibody positive. | Laboratory findings consistent with the diagnosis of Evans syndrome include [[anemia]], direct coombs test positive, and antineutrophil antibody positive. | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
* The diagnosis of Evan’s Syndrome is based primarily on laboratory findings, as well as the corresponding physical signs and symptoms. | * The diagnosis of Evan’s Syndrome is based primarily on laboratory findings, as well as the corresponding physical signs and symptoms. | ||
:* A [[complete blood count]] (CBC) will confirm the presence of [[anemia]] and | :* A [[complete blood count]] (CBC) will confirm the presence of [[anemia]] and [[thrombocytopenia|low platelets]]. | ||
:* Peripheral smear - A [[peripheral smear]] of the blood may reveal evidence of red blood cell destruction or [[reticulocytosis]]. [[Reticulocytes]] are immature red blood cells and are usually abundant in Evan’s syndrome where there is a need to replace ongoing losses. There are also distinct shapes | :* Peripheral smear - A [[peripheral smear]] of the blood may reveal evidence of red blood cell destruction or [[reticulocytosis]]. [[Reticulocytes]] are immature red blood cells and are usually abundant in Evan’s syndrome where there is a need to replace ongoing losses. There are also distinct shapes of certain cells that may be found when a sample of the patient’s blood is viewed under a microscope. In patients with Evan’s syndrome the red blood cells may appear small and globular shaped (then called [[spherocytes]]) but will not be fragmented. | ||
:* A [[Coombs test]] is used to detect the presence of antibodies against the RBC and is usually positive in immune mediated [[hemolysis]]. | :* A [[Coombs test]] is used to detect the presence of antibodies against the RBC and is usually positive in immune-mediated [[hemolysis]]. | ||
:* Other antibodies | :* Other antibodies directed against [[neutrophil]]s and [[lymphocyte]]s may be present.<ref name="pmid7104228">{{cite journal |author=Pegels JG, Helmerhorst FM, van Leeuwen EF, van de Plas-van Dalen C, Engelfriet CP, von dem Borne AE |title=The Evans syndrome: characterization of the responsible autoantibodies |journal=Br. J. Haematol. |volume=51 |issue=3 |pages=445–50 |year=1982 |pmid=7104228 |doi=10.1111/j.1365-2141.1982.tb02801.x}}</ref> | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Latest revision as of 17:09, 2 February 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
Laboratory findings consistent with the diagnosis of Evans syndrome include anemia, direct coombs test positive, and antineutrophil antibody positive.
Laboratory Findings
- The diagnosis of Evan’s Syndrome is based primarily on laboratory findings, as well as the corresponding physical signs and symptoms.
- A complete blood count (CBC) will confirm the presence of anemia and low platelets.
- Peripheral smear - A peripheral smear of the blood may reveal evidence of red blood cell destruction or reticulocytosis. Reticulocytes are immature red blood cells and are usually abundant in Evan’s syndrome where there is a need to replace ongoing losses. There are also distinct shapes of certain cells that may be found when a sample of the patient’s blood is viewed under a microscope. In patients with Evan’s syndrome the red blood cells may appear small and globular shaped (then called spherocytes) but will not be fragmented.
- A Coombs test is used to detect the presence of antibodies against the RBC and is usually positive in immune-mediated hemolysis.
- Other antibodies directed against neutrophils and lymphocytes may be present.[1]
References
- ↑ Pegels JG, Helmerhorst FM, van Leeuwen EF, van de Plas-van Dalen C, Engelfriet CP, von dem Borne AE (1982). "The Evans syndrome: characterization of the responsible autoantibodies". Br. J. Haematol. 51 (3): 445–50. doi:10.1111/j.1365-2141.1982.tb02801.x. PMID 7104228.