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| __NOTOC__
| | #redirect[[Cryptogenic organizing pneumonia]] |
| {{DiseaseDisorder infobox |
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| Name = {{PAGENAME}} |
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| Image = |
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| Caption = |
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| ICD10 = |
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| ICD9 = {{ICD9|516.8}} |
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| ICDO = |
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| OMIM = |
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| DiseasesDB = 31684 |
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| MedlinePlus = |
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| MeshID = |
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| }}
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| {{Cryptogenic organizing pneumonitis}}
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| {{CMG}}
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| {{SK}} Bronchiolitis obliterans organizing pneumonia; BOOP; COP
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| ==Overview==
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| ==Epidemiology==
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| ==Etiology==
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| COP/BOOP may be triggered by infections from bacteria, viruses and parasites, drugs, or toxic fumes.
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| ==Diagnosis==
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| Almost 75% of people have symptoms for less than two months before seeking medical attention. A flu-like illness, with a [[cough]], [[fever]], a feeling of illness ([[malaise]]), [[fatigue]], and [[weight loss]] heralds the onset in about 40% of patients. Doctors do not find any specific abnormalities on routine laboratory tests or on a physical examination, except for the frequent presence of crackling sounds (called Velcro [[crackles]], they are "drier" and higher pitched than traditional [[rales]]) on auscultation. Pulmonary function tests usually show that the amount of air the lungs can hold is below normal. Hypoxemia at rest which is exacerbated with exercise may be present.
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| The [[chest x-ray]] is distinctive with features that appear similar to an extensive [[pneumonia]], with both lungs showing widespread white patches. The white patches may seem to migrate from one area of the lung to another as the disease persists or progresses. Computed Tomography (CT) may be used to confirm the diagnosis. Bronchoscopic lung biopsy can confirm the diagnosis. In some patients, additional tissue may be required and may be obtained surgically.
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| ==Treatment==
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| About two thirds of patients recover with corticosteroid therapy. Prednisolone is often administered in Europe and Prednisone in the USA. These two compounds differ by only one functional group and have the same clinical effect. The steroid is initially administered at high doses, typically 50 mg per day tapering down to zero over a 6 month to one year period. If the steroid treatment is halted too quickly the disease may return.
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| ==References==
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| [http://www.merck.com/mmpe/sec05/ch055/ch055b.html#sec05-ch055-ch055b-821 The Merck Manual of Medical Information - Online Edition]
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| [[Category:Infectious disease]]
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| [[Category:Pulmonology]]
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