Hypergammaglobulinemia history and symptoms: Difference between revisions

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==History==
==History==
*A positive family history of hypergammaglobulinemia may be present.
*History of severe and/or recurrent bacterial respiratory and gastrointestinal infections as well as opportunistic infections may be present in patients with x-linked hyper-IgM.


==Symptoms==
==Symptoms==
===Type 1 Hyper-IgM Immunodeficiency===
===Type 1 Hyper-IgM Immunodeficiency===
*Symptoms of type 1 hyper-IgM immunodeficiency are a result of infections and may include the following:
*The majority of patients with x-linked hyper-IgM are symptomatic by infancy.<ref name="pmid19597006">{{cite journal| author=Fried AJ, Bonilla FA| title=Pathogenesis, diagnosis, and management of primary antibody deficiencies and infections. | journal=Clin Microbiol Rev | year= 2009 | volume= 22 | issue= 3 | pages= 396-414 | pmid=19597006 | doi=10.1128/CMR.00001-09 | pmc=PMC2708392 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19597006  }} </ref>
*Symptoms of type 1 hyper-IgM immunodeficiency are a result of infection and may include the following:
**Fever
**Cough
**Cough
**Tachypnea
**Tachypnea
**Dyspnea  
**Dyspnea  
**Diarrhea
**Diarrhea
*Other symptoms may include:
**Pruritis


==References==
==References==

Latest revision as of 13:23, 2 March 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]

Overview

History

  • A positive family history of hypergammaglobulinemia may be present.
  • History of severe and/or recurrent bacterial respiratory and gastrointestinal infections as well as opportunistic infections may be present in patients with x-linked hyper-IgM.

Symptoms

Type 1 Hyper-IgM Immunodeficiency

  • The majority of patients with x-linked hyper-IgM are symptomatic by infancy.[1]
  • Symptoms of type 1 hyper-IgM immunodeficiency are a result of infection and may include the following:
    • Fever
    • Cough
    • Tachypnea
    • Dyspnea
    • Diarrhea
  • Other symptoms may include:
    • Pruritis

References

  1. Fried AJ, Bonilla FA (2009). "Pathogenesis, diagnosis, and management of primary antibody deficiencies and infections". Clin Microbiol Rev. 22 (3): 396–414. doi:10.1128/CMR.00001-09. PMC 2708392. PMID 19597006.

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