DRESS syndrome diagnostic criteria: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{DRESS syndrome}} | {{DRESS syndrome}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}} {{YD}}, {{SSK}} | ||
==Overview== | ==Overview== | ||
There is no gold standard for the diagnosis of DRESS syndrome. Two diagnostic criteria have been proposed: The RegiSCAR criteria and the Japanese Consensus Group criteria. | |||
==Diagnostic Criteria== | ==Diagnostic Criteria== | ||
*There is no gold standard for the diagnosis of DRESS | *There is no gold standard for the diagnosis of DRESS syndrome. | ||
*Two diagnostic criteria have been proposed: | *Two diagnostic criteria have been proposed: | ||
:*The RegiSCAR criteria <ref name=Kardaun>{{cite journal |vauthors=Kardaun SH, Sidoroff A, Valeyrie-Allanore L, etal |title=Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist? |journal=Response Br J Dermatol |volume=156 |pages=609–610 |year=2007 |pmid=17300272 |doi=10.1111/j.1365-2133.2006.07704.x |issue=3 }}</ref> | :*The RegiSCAR criteria<ref name=Kardaun>{{cite journal |vauthors=Kardaun SH, Sidoroff A, Valeyrie-Allanore L, etal |title=Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist? |journal=Response Br J Dermatol |volume=156 |pages=609–610 |year=2007 |pmid=17300272 |doi=10.1111/j.1365-2133.2006.07704.x |issue=3 }}</ref> | ||
:*The Japanese | :*The Japanese Consensus Group criteria<ref name=Shiohara>{{cite journal |author=Shiohara T, Iijima M, Ikezawa Z, Hashimoto K. |title=The diagnosis of DRESS syndrome has been sufficiently established on the basis of typical clinical features and viral reactivations|journal=Response Br J Dermatol |volume=156 |pages=1045–92 |year=2007 |pmid=17381452 |issue=5 |doi=10.1111/j.1365-2133.2007.07807.x }}</ref> | ||
The following table illustrates the diagnostic criteria for the diagnosis of DRESS syndrome based on the RegiSCAR criteria and the Japanese consensus group criteria: | |||
{| class="wikitable" | {| class="wikitable" | ||
|- | |- | ||
! RegiSCAR inclusion criteria for DRESS syndrome | ! RegiSCAR inclusion criteria for DRESS syndrome<br>''At least three of the four starred criteria are required for diagnosis'' !! Japanese Consensus Group diagnostic criteria for DRESS/DIHS syndrome<br>''A total of Seven criteria needed for the diagnosis of typical DRESS/DIHS syndrome / the first five criteria are required for the diagnosis of atypical DRESS/DIHS syndrome'' | ||
|- | |- | ||
| | | Acute Rash* || Maculopapular rash > 3 weeks following administration of drug | ||
|- | |- | ||
| | | Fever > 38 °C* || Prolonged clinical symptoms 2 weeks following the discontinuation of the suspected drug | ||
|- | |- | ||
| | | [[Lymphadenopathy]] in at least two sites* || Fever > 38 °C | ||
|- | |- | ||
| | | Involvement of at least one internal organ* || Liver function test abnormalities (ALT > 100 U/L) or other organ involvement | ||
|- | |- | ||
| | | Hospitalization || [[Leukocyte]] abnormalities | ||
|- | |- | ||
| | | Reaction suspected to be drug-related || [[Leukocytosis]] ( > 11 x 10<sup>9</sup>/L) | ||
|- | |- | ||
| Blood count abnormalities (lymphopenia or lymphocytosis | | Blood count abnormalities (lymphopenia or lymphocytosis, eosinophilia, thrombocytopenia)|| Atypical lymphocytosis (>5%) | ||
|- | |- | ||
| || Lymphadenopathy | | || Lymphadenopathy | ||
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==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Dermatology]] | [[Category:Dermatology]] | ||
[[Category:Hematology]] | [[Category:Hematology]] | ||
[[Category:Hepatology]] | [[Category:Hepatology]] | ||
{{WS}} | |||
{{WH}} | |||
Latest revision as of 13:23, 20 July 2016
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DRESS syndrome Microchapters |
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DRESS syndrome On the Web |
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American Roentgen Ray Society Images of DRESS syndrome |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Yazan Daaboul, M.D., Serge Korjian M.D.
Overview
There is no gold standard for the diagnosis of DRESS syndrome. Two diagnostic criteria have been proposed: The RegiSCAR criteria and the Japanese Consensus Group criteria.
Diagnostic Criteria
- There is no gold standard for the diagnosis of DRESS syndrome.
- Two diagnostic criteria have been proposed:
The following table illustrates the diagnostic criteria for the diagnosis of DRESS syndrome based on the RegiSCAR criteria and the Japanese consensus group criteria:
| RegiSCAR inclusion criteria for DRESS syndrome At least three of the four starred criteria are required for diagnosis |
Japanese Consensus Group diagnostic criteria for DRESS/DIHS syndrome A total of Seven criteria needed for the diagnosis of typical DRESS/DIHS syndrome / the first five criteria are required for the diagnosis of atypical DRESS/DIHS syndrome |
|---|---|
| Acute Rash* | Maculopapular rash > 3 weeks following administration of drug |
| Fever > 38 °C* | Prolonged clinical symptoms 2 weeks following the discontinuation of the suspected drug |
| Lymphadenopathy in at least two sites* | Fever > 38 °C |
| Involvement of at least one internal organ* | Liver function test abnormalities (ALT > 100 U/L) or other organ involvement |
| Hospitalization | Leukocyte abnormalities |
| Reaction suspected to be drug-related | Leukocytosis ( > 11 x 109/L) |
| Blood count abnormalities (lymphopenia or lymphocytosis, eosinophilia, thrombocytopenia) | Atypical lymphocytosis (>5%) |
| Lymphadenopathy | |
| Human herpesvirus 6 reactivation |
References
- ↑ Kardaun SH, Sidoroff A, Valeyrie-Allanore L, et al. (2007). "Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist?". Response Br J Dermatol. 156 (3): 609–610. doi:10.1111/j.1365-2133.2006.07704.x. PMID 17300272.
- ↑ Shiohara T, Iijima M, Ikezawa Z, Hashimoto K. (2007). "The diagnosis of DRESS syndrome has been sufficiently established on the basis of typical clinical features and viral reactivations". Response Br J Dermatol. 156 (5): 1045–92. doi:10.1111/j.1365-2133.2007.07807.x. PMID 17381452.