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{{Porphyria cutanea tarda}}
{{CMG}}; {{AE}}
==Overview==
==Overview==
'''Porphyria cutanea tarda''' (PCT) is the most common subtype of [[porphyria]]. The disorder results from low levels of the [[enzyme]] responsible for the [[uroporphyrinogen III decarboxylase|fifth step]] in [[heme]] production. Heme is a vital molecule for all of the body's organs. It is a component of [[hemoglobin]], the molecule that carries [[oxygen]] in the blood.
'''Porphyria cutanea tarda''' (PCT) is the most common subtype of [[porphyria]]. The disorder results from low levels of the [[enzyme]] responsible for the [[uroporphyrinogen III decarboxylase|fifth step]] in [[heme]] production. Heme is a vital molecule for all of the body's organs. It is a component of [[hemoglobin]], the molecule that carries [[oxygen]] in the blood.


==Causes==
==Classification==
*In the acquired form, the signs and symptoms of this condition are triggered by non genetic factors such as alcohol abuse, excess iron, certain hormones, and viral infections. However, in the inherited form of the disease, which affects up to 20% of PCT patients, the condition arises from a mutation in the uroporphyrinogen decarboxylase gene, although environmental and chemical factors may trigger or exacerbate symptoms.
*In the acquired form, the signs and symptoms of this condition are triggered by non genetic factors such as alcohol abuse, excess iron, certain hormones, and viral infections. However, in the inherited form of the disease, which affects up to 20% of PCT patients, the condition arises from a mutation in the uroporphyrinogen decarboxylase gene, although environmental and chemical factors may trigger or exacerbate symptoms.
*Drug side effect: [[Chlorpropamide]], [[Tolbutamide]], [[Tolazamide]]
*Drug side effect: [[Chlorpropamide]], [[Tolbutamide]], [[Tolazamide]]
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==References==
==References==
{{reflist}}
{{reflist}}
[[Category:Endocrinology]]
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{{WH}}

Latest revision as of 19:23, 25 July 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Porphyria cutanea tarda (PCT) is the most common subtype of porphyria. The disorder results from low levels of the enzyme responsible for the fifth step in heme production. Heme is a vital molecule for all of the body's organs. It is a component of hemoglobin, the molecule that carries oxygen in the blood.

Classification

  • In the acquired form, the signs and symptoms of this condition are triggered by non genetic factors such as alcohol abuse, excess iron, certain hormones, and viral infections. However, in the inherited form of the disease, which affects up to 20% of PCT patients, the condition arises from a mutation in the uroporphyrinogen decarboxylase gene, although environmental and chemical factors may trigger or exacerbate symptoms.
  • Drug side effect: Chlorpropamide, Tolbutamide, Tolazamide

References

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